Modification of Silicone Hydrogel Contact Lenses for the Selective Adsorption of Ofloxacin

Abstract

It is essential to design multifunctional contact lenses for selective recognition and utilization of the eye drop ofloxacin (OFL). Modified silicone hydrogel (MSL) contact lenses were firstly synthesized via ultraviolet curing by using (hydroxymethyl)methyl aminomethane, polydimethylsiloxane, methacryloxypropyl terminated polydimethylsiloxane, and N,N-dimethylacrylamide as monomers and N-vinyl-2-pyrrolidinone (NVP) as a modifier. The synthesized MSL contact lenses were characterized via Fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle and mechanical property tests. The results showed that compared with silicone hydrogel (SL) contact lenses, the MSL contact lenses had a more porous structure and good swelling and mechanical properties. The molecularly imprinted polymer/ofloxacin-modified silicone hydrogel (MIP/OFL-MSL) contact lenses were firstly synthesized via free radical polymerization, using ofloxacin (OFL) as the template molecule. Moreover, compared with chlorogenic acid and myricetin molecule, the MIP/OFL-MSL contact lenses exhibited an adsorption capacity for OFL that reached 2.86 mg/g. The antibacterial test showed that the MIP/OFL-MSL contact lenses displayed an inhibition ring size of 15.2 mm and 17.8 mm for Staphylococcus aureus and Escherichia coli, respectively.

Hydrogel for light delivery in biomedical applications

“…In terms of optical applications, hydrogels have been studied on for vitreous tamponades [ 11 ], drug delivery contact lenses [ 141 , 142 ], delivering light into deep tissue for clinical applications including optogenetic stimulation [ 55 ], photodynamic therapy, [ 143 ], real-time in-vivo tissue imaging, [ 144 ], as well as biological sensing [ 145 , 146 ]. Hydrogels are able to break the limitations of traditional optical materials such as glass, crystals, rigid polymer, semi-conductors which are prone to injuring the soft tissues when implanted due to their stiffness and brittleness [ 147 ].…”

Modification of Silicone Hydrogel Contact Lenses with Vitamin E for the Delivery of Ofloxacin

“…Many types of contact lenses, including nanoparticle-based [13], layer-structured [14], biomimetic [15], and imprinted [16] contact lenses, have been used to increase the release duration of drug. Vitamin E (VE) is a fat-soluble antioxidant that can inhibit keratocyte apoptosis after surgery and prevent glaucoma [17].…”