Modification of porous calcium phosphate surfaces with different geometries of bioactive glass nanoparticles

Roohani‐Esfahani, Seyed‐Iman; Nouri-Khorasani, S.; Lu, Zufu; Fathi, M.H.; Razavi, Mehdi; Appleyard, Richard; Zreiqat, Hala

doi:10.1016/j.msec.2012.01.034

Cited by 17 publications

(12 citation statements)

References 47 publications

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“…Roohani-Esfahani et al investigated various nHA shapes (needle: length = 110 nm, width = 25 nm; spherical: diameter = ~30 nm; rod: length = 41 nm, width = 17 nm) incorporated onto PCL-coated biphasic calcium phosphate (PCL-BCP) scaffolds and showed that scaffolds with needle-shaped nHA showed the best osteogenic differentiation of human osteoblasts [89]. A similar observation was also made with various shapes of nBG particles (needle: length = ~153 nm, width = ~29 nm; large spheres: diameter = ~68 nm; small spheres: diameter = 35 nm) incorporated onto PCL-BCP, where needle-shaped nBG particles were best able to induce osteogenic differentiation of human osteoblasts, followed by the small spherical nHA-PCL-nBG group [90].…”

Section: Morphologysupporting

confidence: 66%

Nanomaterials: The Next Step in Injectable Bone Cements

Roohani‐Esfahani

Zreiqat

2014

Nanomedicine

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Injectable bone cements (IBCs) are biocompatible materials that can be used as bone defect fillers in maxillofacial surgeries and in orthopedic fracture treatment in order to augment weakened bone due to osteoporosis. Current clinically available IBCs, such as polymethylmethacrylate and calcium phosphate cement, have certain advantages; however, they possess several drawbacks that prevent them from gaining universal acceptance. New gel-based injectable materials have also been developed, but these are too mechanically weak for load-bearing applications. Recent research has focused on improving various injectable materials using nanomaterials in order to render them suitable for bone tissue regeneration. This article outlines the requirements of IBCs, the advantages and limitations of currently available IBCs and the state-of-the-art developments that have demonstrated the effects of nanomaterials within injectable systems.

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Section: Morphologysupporting

confidence: 66%

Nanomaterials: The Next Step in Injectable Bone Cements

Roohani‐Esfahani

Zreiqat

2014

Nanomedicine

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“…With proper surface modification, cells can grow on materials otherwise biologically incompatible including plastics and inorganic platforms, such as polyester, polycaprolactone, polyetheretherketone, alumina and calcium phosphate. [5] These modified surfaces have been used for in vitro cell culture, [6] tissue regeneration and organ rebuilding. [7] Selectivity of cell proliferation on surfaces is an additional requirement for multiple applications, including wound healing, [8] tissue repair, [9] and cellular applications including cell residence, development, and differentiation.…”

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confidence: 99%

Rapid Coating of Surfaces with Functionalized Nanoparticles for Regulation of Cell Behavior

et al. 2014

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“…Recent studies showed that increasing specific surface area and pore volume of BG may greatly accelerate the deposition process of hydroxyapatite (6). Researchers revealed that the biomaterials in nano-scale could stimulate the reaction between materials and cells (15)(16)(17). Recently, nano-bioactive glasses (NBG) particles were prepared by Brunner et al using flame synthesis, (18) but the flame synthesis needs high temperature environment.…”

Section: Influences Of Molecular Weight and Content Of Polyethylene Gmentioning

confidence: 99%

Influences of Molecular Weight and Content of Polyethylene Glycol on Morphology and Size of Nano-Bioactive Glass

Zhou

Huang

et al. 2014

Journal of Macromolecular Science, Part A

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Nano-bioactive glass (NBG) was prepared via sol-gel method and freeze-dried technique using polyethylene glycol (PEG) as templates. The influences of molecular weight and content of polyethylene glycol on the morphology and the size NBG particles were investigated. The optimal sintering temperature of NBG was determined by using thermal gravimetric (TG) and differential thermal analysis (DTA), and the NBG particles were characterized by Fourier-transformed infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD). The XRD pattern of NBG sintered at 650 • C in air confirmed that the calcined glass existed in amorphous state. The results indicated that the PEG molecular weight and PEG content have obvious effects on the morphology and size of the NBG particles. The size of NBG particle prepared with PEG-200 was beyond 1μm and the aggregation was obvious. The size of obtained NBG particle with PEG-10000 was between 50 nm and 80 nm, with a hollow spherical shape; while the morphology of the NBG with PEG-20000 was needle-shaped, with an average width of 20 nm and length of 100 nm. The particle size of the NBG particles decreased with the increase of PEG concentration.

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Modification of porous calcium phosphate surfaces with different geometries of bioactive glass nanoparticles

Cited by 17 publications

References 47 publications

Nanomaterials: The Next Step in Injectable Bone Cements

Nanomaterials: The Next Step in Injectable Bone Cements

Rapid Coating of Surfaces with Functionalized Nanoparticles for Regulation of Cell Behavior

Influences of Molecular Weight and Content of Polyethylene Glycol on Morphology and Size of Nano-Bioactive Glass

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