Modification of polyurethaneurea with PEG and YIGSR peptide to enhance endothelialization without platelet adhesion

Jun, Ho−Wook; West, Jennifer L.

doi:10.1002/jbm.b.30135

Cited by 93 publications

(72 citation statements)

References 22 publications

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“…Polyurethanes incorporated with YIGSR selectively promoted EC adhesion and proliferation while minimizing platelet adhesion [40,41]. Glass [42] and PEG hydrogels [43] modified with YIGSR also enhanced EC adhesion and migration.…”

Section: Modifications With Ecm-derived Peptides-cellular Interactionmentioning

confidence: 99%

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Moon¹,

West²

2008

CTMC

206

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Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.

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Section: Modifications With Ecm-derived Peptides-cellular Interactionmentioning

confidence: 99%

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Moon¹,

West²

2008

CTMC

206

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“…Polyethylene glycol (PEG) resists protein adsorption, platelet adhesion, and bacterial adhesion, [8][9][10][11][12][13] making it an attractive material for incorporation into vascular prostheses, and numerous methods have been developed to integrate PEG into biomaterials, including polyurethanes, through copolymerization and surface modification. 8,12,[14][15][16][17][18][19][20] The incorporation of cell adhesion moieties into vascular grafts is also employed as a means of enhancing graft function by encouraging endothelialization. Endothelial cell seeding has been extensively studied as a method to improve the long-term patency of synthetic grafts by providing the naturally nonthrombogenic luminal interface present in a normal blood vessel.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide‐releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion

et al. 2007

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Thrombosis and intimal hyperplasia are the principal causes of small-diameter vascular graft failure. To improve the long-term patency of polyurethane vascular grafts, we have incorporated both poly(ethylene glycol) and a diazeniumdiolate nitric oxide (NO) donor into the backbone of polyurethane to improve thromboresistance. Additionally, we have incorporated the laminin-derived cell adhesive peptide sequence YIGSR to encourage endothelial cell adhesion and migration, while NO release encourages endothelial cell proliferation. NO production by polyurethane films under physiological conditions demonstrated biphasic release, in which an initial burst of 70% of the incorporated NO was released within 2 days, followed by sustained release over 2 months. Endothelial cell proliferation in the presence of the NO-releasing material was increased as compared to control polyurethane, and platelet adhesion to polyethylene glycol-containing polyurethane was decreased significantly with the addition of the NO donor.

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“…The integrin-binding activity of natural adhesion proteins can be partially mimicked by oligopepetide sequences [95,96], such as the ubiquitous RGD (i.e., arginineglycine-aspartic acid) [97][98][99][100], RGD and PHSRN (i.e., proline-histidine-serine-arginineasparagine) (in synergy) [101,102], IKVAV (i.e., isoleucine-lysine-valine-alanine-valine) [103][104][105], YIGSR (tyrosine-isoleucine-glycine-serine-arginine) [106,107], PHSRN , and so on. Harden et al went a step further from the triblock architecture initially proposed by Tirrell et al by conjugating RGD to the central block of the modular triblock protein architecture.…”

Section: Artificial Protein Hydrogelsmentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

555

364

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This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

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Modification of polyurethaneurea with PEG and YIGSR peptide to enhance endothelialization without platelet adhesion

Cited by 93 publications

References 22 publications

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Nitric oxide‐releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion

Smart polymeric gels: Redefining the limits of biomedical devices

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