Modification of polysiloxane polymers for biomedical applications: a review

Abbasi, Farhang; Mirzadeh, Hamid; Katbab, Ali Asghar

doi:10.1002/pi.783

Cited by 457 publications

(326 citation statements)

References 101 publications

Supporting

Mentioning

316

Contrasting

Order By: Relevance

“…In addition to modification of surface chemical composition, plasma techniques have also been used to modify the surface morphology (roughening) of polymeric surfaces aiming for example at changes in wetting behaviour [6][7][8]. Poly(dimethylsiloxane) (PDMS) is a commercially available type of silicone rubber widely used in the fabrication of medical [9] and microfluidic devices [10], and as foul-release coating to control marine biofouling [11,12]. Foul-release coatings are currently a successful non-toxic, environmentally friendly alternative to classical biocide-containing coatings [12].…”

Section: Introductionmentioning

confidence: 99%

Fluorination of poly(dimethylsiloxane) surfaces by low pressure CF4 plasma – physicochemical and antifouling properties

Cordeiro¹,

Nitschke²,

Janke³

et al. 2009

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract. Fluorinated surface groups were introduced into poly(dimethylsiloxane) (PDMS) coatings by plasma treatment using a low pressure radio frequency discharge operated with tetrafluoromethane. Substrates were placed in a remote position downstream the discharge. Discharge power and treatment time were tuned to alter the chemical composition of the plasma treated PDMS surface. The physicochemical properties and stability of the fluorine containing PDMS were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and contact angle measurements. Smooth PDMS coatings with a fluorine content up to 47% were attainable. The CF4 plasma treatment generated a harder, non-brittle layer at the top-most surface of the PDMS. No changes of surface morphology were observed upon one week incubation in aqueous media. Surprisingly, the PDMS surface was more hydrophilic after the introduction of fluorine. This may be explained by an increased exposure of oxygen containing moieties towards the surface upon re-orientation of fluorinated groups towards the bulk, and/or be a consequence of oxidation effects associated with the plasma treatment. Experiments with strains of marine bacteria with different surface energies, Cobetia marina and Marinobacter hydrocarbonoclasticus, showed a significant decrease of bacteria attachment upon fluorination of the PDMS surface. Altogether, the CF4 plasma treatments successfully introduced fluorinated groups into the PDMS, being a robust and versatile surface modification technology that may find application where a minimization of bacterial adhesion is required.

show abstract

Section: Introductionmentioning

confidence: 99%

Fluorination of poly(dimethylsiloxane) surfaces by low pressure CF4 plasma – physicochemical and antifouling properties

Cordeiro¹,

Nitschke²,

Janke³

et al. 2009

Express Polym. Lett.

View full text Add to dashboard Cite

show abstract

“…As an example, the use of monolayers to generate desired surface states for biosensing is discussed below. Surface modification has been essential for biosensors to immobilize affinity tags for binding of target molecules to surfaces [133][134][135][136][137][138]. For example, several platforms for cell, protein and DNA assays have been investigated [74,[139][140][141][142][143][144].…”

Section: (C) Surface Modificationmentioning

confidence: 99%

Theory, fabrication and applications of microfluidic and nanofluidic biosensors

Prakash

Pinti

Bhushan

2012

Phil. Trans. R. Soc. A.

View full text Add to dashboard Cite

Biosensors are a broad array of devices that detect the type and amount of a biological species or biomolecule. Several different types of biosensors have been developed that rely on changes to mechanical, chemical or electrical properties of the transduction or sensing element to induce a measurable signal. Often, a biosensor will integrate several functions or unit operations such as sample extraction, manipulation and detection on a single platform. This review begins with an overview of the current state-of-the-art biosensor field. Next, the review delves into a special class of biosensors that rely on microfluidics and nanofluidics by presenting the underlying theory, fabrication and several examples and applications of microfluidic and nanofluidic sensors.

show abstract

“…At present, the surface modiication of silicone rubber can be treated by plasma treatment, grafting copolymerization, and biomimetic coating, but there are some defects, such as the steps were cumbersome and substrate temperature and the conditions are not easy to control [11][12][13][14][15][16][17][18]. In this study, the technology of ion implantation which is mainly used in metal and semiconductor materials is introduced into the surface modiication of silicone rubber material.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Preliminary Biocompatibility Evaluation of Carbon Ion-Implanted Silicone Rubber

Zhou¹,

Zhang²,

Shi³

et al. 2017

Elastomers

View full text Add to dashboard Cite

Silicone rubber (SR) is a common soft tissue iller material used in plastic surgery. However, it sufers from poor biocompatibility. Previous studies have found that the ion implantation technology can be used to improve the biocompatibility of metal materials. However, it is not clear whether it can improve the biocompatibility of polymer materials. In this study, carbon ion SR was prepared by carbon ion implantation. After that, the characteristics of ion implanted SR were investigated. Then, Escherichia coli was utilized to test the antibacterial ability of the carbon ion implanted SR. Besides, the dermal ibroblasts were used to evaluate the cytocompatibility. From the results, carbon ion implantation had no signiicant efect on the hardness, tensile strength and elongation at break of SR. At the same time, there was no signiicant change in the surface morphology of SR. But the results show that the surface nano-morphology, surface element composition, hydrophobic and ζ potential of the surface of SR changed signiicantly. The changes further mediated the lower adhesion of bacteria and enhanced biocompatibility. In conclusion, the carbon ion implantation technology can improve the surface properties of silicone rubber, and further improve its biocompatibility.

show abstract

Modification of polysiloxane polymers for biomedical applications: a review

Cited by 457 publications

References 101 publications

Fluorination of poly(dimethylsiloxane) surfaces by low pressure CF4 plasma – physicochemical and antifouling properties

Fluorination of poly(dimethylsiloxane) surfaces by low pressure CF4 plasma – physicochemical and antifouling properties

Theory, fabrication and applications of microfluidic and nanofluidic biosensors

Preparation, Characterization, and Preliminary Biocompatibility Evaluation of Carbon Ion-Implanted Silicone Rubber

Contact Info

Product

Resources

About