Modification of polyethersulfone membranes using terpolymers engineered and integrated antifouling and anticoagulant properties

Abstract

In this study, random terpolymers of methoxy poly(ethylene glycol)-poly(sodium styrene sulfonate-co-methyl methacrylate) (MPEG-P(SSNa-co-MMA)) integrated with antifouling and anticoagulant properties were synthesized by atom transfer radical polymerization (ATRP) for the first time and confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and gel permeation chromatography (GPC). The terpolymers with desired antifouling and anticoagulant segments were then used as amphiphilic additives to modify polyethersulfone membranes by an engineering blended approach. Water contact angle (WCA) results indicated that the surface hydrophilicity of the modified membranes enhanced. Protein ultrafiltration experiments showed that the antifouling ability of the modified membranes increased. In addition, the modified membranes showed decreased protein adsorption (bovine serum albumin, BSA), suppressed platelet adhesion, and prolonged activated partial thromboplastin time (APTT).

Heparin-Mimicking Polymer Modified Polyethersulfone Membranes - A Mini Review

“…The modified membranes possessed decreased protein adsorbed amounts and suppressed platelet adhesion (as shown in Figure 5). Moreover, the APTT of the modified membranes was [24] citric acid grafted polyurethane plasma separation [53] P(St-co-AA)-b-PVP-b-P(St-co-AA) hemodialysis [54] su fated P(St-co-AA)-b-PVP-b-P(St-co-AA) hemodialysis [29] MPEG-P(SSNa-co-MMA) hemofiltration [56] sulfonated PES plasma separation [57][58][59][60] P(AN-AA-VP) hemofiltration [58] carboxylic PES hemofiltration [59] P(AA-NaSS-VP) plasma separation [61] blending P(HEMA-AA) plasma separation [62] P(NaSS-AA), dopamine hemofiltration [63] CHI/PSS multilayer protein separation [64] PSS /protonated PAH; PSS/ PDADMAC hemofiltration [65] Coating Ag NPs/PEI/PSS antibacterial [66] HEMA, NVP; AAG, AA; AMPS, SPMA hemofiltration [67,68] zwitterionic copolymers plasma separation [70] Grafting P(SBMA-NaSS) plasma separation [71] increased about 60% compared to the pristine PES membrane. The study provided a method to modify polymeric membranes using heparin-like polymers.…”

“…Besides RAFT technique, atom transfer radical polymerization (ATRP) can also be used for the synthesis of heparin-like polymers. He et al [56] synthesized a random terpolymer of MPEG-P(SSNaco-MMA) by ATRP for the first time, which was then used as an additive for the modification of PES membranes by blending method. The results illustrated that the hydrophilicity was increased for the modified membranes, and the antifouling property of the modified membrane was improved compared to the pristine PES membrane.…”

Exploring the effect of organic–inorganic additives loaded on modified polyethersulfone membranes

“…19-22. Thus, there are many studies developed different anticoagulant PES membranes by the attachments of negatively charged functions, biomolecules such as heparin, bovine serum albumin, and heparinlike molecules to the PES backbone in order to obtain anticoagulant activity. 23 PES membranes with heparinization surface exhibited the highest anticoagulant activity. 24 Therefore, it was found that the chemical modification of PES with ionic molecules or functions such as sulfamide, carboxylic, and sulfate provided anticoagulant activity since these functions are present in heparin, and their presence in PES membranes would provide similar activity.…”

“…. Thus, there are many studies developed different anticoagulant PES membranes by the attachments of negatively charged functions, biomolecules such as heparin, bovine serum albumin, and heparin‐like molecules to the PES backbone in order to obtain anticoagulant activity . PES membranes with heparinization surface exhibited the highest anticoagulant activity .…”

Hemocompatibility and ultrafiltration performance of PAN membranes surface-modified by hyperbranched polyesters

“…Ultrafiltration (UF) membranes have been widely applied in the fields of wastewater treatment, water purification, and hemodialysis, among others . In hemodialysis and wastewater treatment, in particular, polyacrylonitrile (PAN) is one of the most important polymeric materials because of its chemical stability, strong antioxidant capacity, and strong antibacterial properties .…”