Modification of poly(ether urethane) with fluorinated phosphorylcholine polyurethane for improvement of the blood compatibility

Abstract

In order to improve the blood compatibility, poly(ether urethane) (PEU) and fluorinated phosphorylcholine polyurethane (P-HFPC) were used to prepare PU/P-HFPC blends by solution mixing. The hemocompatibility in vitro was evaluated with protein adsorption and platelet-rich plasma (PRP) contact tests. It was found that the amount of adsorbed protein on surface was decreased by 87%, and almost no platelet adhesion and activation was observed on the surface of blends when P-HFPC content was above 5 wt %. After adding P-HFPC, the blends basically kept favorable mechanical properties of PEU though the content of P-HFPC rises to 20 wt %. To better understand the relationship between structure and properties, the phase structure and surface property of the blend films were further investigated via differential scanning calorimetry, dynamic mechanical analysis, atomic force microscopy, X-ray photoelectron spectroscopy, and contact angle measurements. The results indicated that the fluorinated phosphorylcholine units could be easily enriched on the surface of blend films due to the phase separation between the PEU and P-HFPC. Therefore, ordinary poly(ether urethane)s can obtain both satisfactory blood compatibility and good mechanical properties just by blending with small amount of P-HFPC.

Plasma functionalization of polycarbonaturethane to improve endothelialization—Effect of shear stress as a critical factor for biocompatibility control

“…22 Covalent binding of fibronectin 23 or RGD peptides 24,25 as well as a laminin-nonapeptide 26 improved integrin-mediated cell adhesion of endothelial cells or progenitor cells. Other strategies such as binding of anticoagulants like heparin, 27 phosphorylcholine, 28 or Argatroban 29 pursued the aim to reduce platelet adhesion, activation and aggregation.…”

Synthesis and surface properties of polyurethane end‐capped with hybrid hydrocarbon/fluorocarbon double‐chain phospholipid

“…In recent years, a series of PUs containing fluorinated alkyl phosphatidylcholine (PC) side groups have been prepared in our group, of which the fluorinated side chain could help PC polar headgroup directly connected migration onto PU surfaces leading to relatively good hemocompatibility for PUs 18–21. In addition, these fluorinated phospholipid polyurethanes (FPCPUs) as blending additives could effectively improve surface properties and hemocompatibility of PUs 22, 23. However, it was found that the mimicking biomembrane surfaces of the PUs forming by fluorocarbon single‐chain PC could not properly suppress protein adsorption, for example, the inhibitory rate of fibrinogen (Fg) adsorption onto these fluorinated PC poly(carbonate urethane)s surfaces compared with that onto pristine poly(carbonate urethane)s surfaces was only to about 75%, similarly ascribed to the unstable self‐assemble structures of the fluorocarbon single‐chain PC 18, 24.…”

Surface modifying oligomers used to functionalize polymeric surfaces: Consideration of blood contact applications

“…On the other hand, the use of small molecules that combine fluoroalkyl and PC moieties simultaneously could address this challenge as it has been shown with low density polyethylene . In this sense, the concept of such SMMs provided a promising strategy since fluorinated alkyl chains can direct the biomimetic phosphatidylcholine moieties toward the surface and simultaneously limit water uptake given the fluorine chemistry's inherent hydrophobicity . Examples of these systems are described in Table .…”

“…The addition of further oligomer did not show any improvement in blood contact character. This was consistent with the XPS results where no changes in phosphorous or fluorine concentration were observed on the surface for concentrations higher than 5% …”