Modification of poly(ether urethane)elastomers by incorporation of poly(isobutylene)glycol. Relation between polymer properties and thrombogenicity

Abstract

Non-polar hydrophobic poly(isobutylene)glycol (PIBG) was substituted for poly(tetramethylene ether)glycol (PTMEG) in poly(ether urethanes) based on 4,4'-methylenebis-(phenylisocyanate) (MDI) and 1,4-butanediol (BD) as chain extender. Two series of polyurethanes differing in their soft segment length, polymer composition, and hard segment content were studied by dynamic mechanical analysis (DMA) and static, as well as dynamic, contact angle measurements. The thrombogenicity of these polymers was characterized by studying the adhesion and activation of platelets using ELISA for GMP 140 and fluorescence microscopy. It was found by DMA that in PIBG-containing polyurethanes (PUE) exist soft domains containing hard segments, strictly separated hard segment domains, and hard segments partially mixed with soft segments. Contact angle measurements revealed that 25% PIBG or even less, are sufficient for a remarkable enrichment of these non-polar soft segments on the polymer surface. The platelet adhesion/activation on these materials was demonstrated to increase with the rise in hard segment content, as well as with an enhancement of the PIBG content. However, comparison of PIBG-containing PUE with medical applied polypropylene and pellethane expressed that PUE with PIBG content equal or less 25% have excellent haemocompatibility.

Thomas Groth, PhD to serve as Co‐Editor, Europe, ESAO Representative

“…During his subsequent PostDoc time at Medical School Charité Berlin, he worked on testing of blood-compatible polymers and membrane materials for novel types of hemodialyzers and other blood-contacting devices. [6][7][8] During this time, Thomas became also interested in ways to improve blood response of polymers by covalent immobilization of anticoagulant heparin 9 and hirudin. 10 Another topic of interest during this time was to understand better the tissue compatibility of biomaterials for medical applications starting some fundamental studies with selected polymers and model surfaces using human fibroblasts and other cells.…”

“…Thomas obtained his PhD in Biophysics at Humboldt University Berlin in 1991. During his subsequent PostDoc time at Medical School Charité Berlin, he worked on testing of blood‐compatible polymers and membrane materials for novel types of hemodialyzers and other blood‐contacting devices . During this time, Thomas became also interested in ways to improve blood response of polymers by covalent immobilization of anticoagulant heparin and hirudin .…”

Modification of a novel polymer with potential use in artificial heart valves : effects on hemocompatibility and mechanical properties

“…Platelet deposition studies showed that the adhesion and activation of plasma proteins, lymphocytes, and platelets increased with increasing hard segment content of the polyurethane (Chen and Wei 1998;Mitzner and Groth 1996).…”