Modification of platinum microelectrode with molecularly imprinted over-oxidized polypyrrole for dopamine measurement in rat striatum

Tsai, Tien Chun; Han, Huan; Cheng, Ching Ching; Chen, Li‐Chia; Chang, Hsien Chang; Chen, Jia Jin Jason

doi:10.1016/j.snb.2011.07.052

Cited by 56 publications

(33 citation statements)

References 53 publications

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“…The overoxidation of the film resulted in a further improvement in the electrochemical response towards dopamine and in an ever more significant improvement of the electrochemical response for ascorbic acid clearly demonstrating, as expected, significant changes in the electrochemical and morphological properties of the film. The obtained film was now a strongly porous and negatively charged perm-selective membrane with significant affinity for positively charged molecules (dopamine and ascorbic acide) as previously reported [35], but with also an expected added affinity towards diol-containing molecules (DA) due to the presence of the boronic group in the film [60]. …”

Section: Resultssupporting

confidence: 59%

Doping Polypyrrole Films with 4-N-Pentylphenylboronic Acid to Enhance Affinity towards Bacteria and Dopamine

et al. 2016

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Here we demonstrate the use of a functional dopant as a fast and simple way to tune the chemical affinity and selectivity of polypyrrole films. More specifically, a boronic-functionalised dopant, 4-N-Pentylphenylboronic Acid (PBA), was used to provide to polypyrrole films with enhanced affinity towards diols. In order to prove the proposed concept, two model systems were explored: (i) the capture and the electrochemical detection of dopamine and (ii) the adhesion of bacteria onto surfaces. The chemisensor, based on overoxidised polypyrrole boronic doped film, was shown to have the ability to capture and retain dopamine, thus improving its detection; furthermore the chemisensor showed better sensitivity in comparison with overoxidised perchlorate doped films. The adhesion of bacteria, Deinococcus proteolyticus, Escherichia coli, Streptococcus pneumoniae and Klebsiella pneumoniae, onto the boric doped polypyrrole film was also tested. The presence of the boronic group in the polypyrrole film was shown to favour the adhesion of sugar-rich bacterial cells when compared with a control film (Dodecyl benzenesulfonate (DBS) doped film) with similar morphological and physical properties. The presented single step synthesis approach is simple and fast, does not require the development and synthesis of functional monomers, and can be easily expanded to the electrochemical, and possibly chemical, fabrication of novel functional surfaces and interfaces with inherent pre-defined sensing and chemical properties.

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Section: Resultssupporting

confidence: 59%

Doping Polypyrrole Films with 4-N-Pentylphenylboronic Acid to Enhance Affinity towards Bacteria and Dopamine

et al. 2016

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“…Interfering species with oxidization potentials similar to that of dopamine and high impedance of common metal microelectrodes are problematic for the common method of amperometric detection. An approach to specifically detect dopamine in the striatum of the rat in vivo using an implantable microelectrode sensor was presented using the "molecularly imprinted polymer" technique [83]. PPy and dopamine were electrodeposited on a platinum substrate and dopamine was washed out using ethanol, leaving a specifically sized cavity in the polymer film.…”

Section: Sensorsmentioning

confidence: 99%

“…Through polymer oxidization, carbonyl and carboxylic groups supposedly increased dopamine specificity by attracting its NH3 group and repelling negatively charged molecules. The OPPy-MIP (overoxidized polypyrrole-molecularly imprinted polymer) microelectrodes proved to be superior compared to non-imprinted polymer electrodes in terms of sensitivity and specificity in vitro as well as in vivo [83].…”

Section: Sensorsmentioning

confidence: 99%

Organic Bioelectronic Tools for Biomedical Applications

2015

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Abstract:Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients. OPEN ACCESSElectronics 2015, 4 880

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“…Furthermore, the use of overoxidized polypyrrole (OPPy) as an immobilizing membrane for BMZ along with the electrocatalytic property of graphene (GR) provide a useful strategy for preparing chiral modified electrodes and offer great promise for nanocomposite-based voltammetric sensor. A porous and permselective OPPy film, as discrimination membrane, has already been used in design of glucose, [20][21][22] alcohol, 23 hydrazine, 24,25 dopamine, [26][27][28][29][30][31] serotonin, 32 cysteine enantiomers, 33 and naproxen 34 sensors. However, the sensitivity of OPPymodified electrode is expected to be poor because of its low conductivity.…”

Section: Introductionmentioning

confidence: 99%

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

Borazjani

Mehdinia

Jabbari

2017

J of Molecular Recognition

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A chiral biosensing platform was developed using betamethasone (BMZ) as chiral recognition element through multilayered electrochemical deposition of BMZ, overoxidized polypyrrole, and nanosheets of graphene (OPPy-BMZ/GR), for enantio-recognition of mandelic acid (MA) enantiomers. The deposited film was characterized by scanning electron microscopy, differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. It was shown that the chiral sensing platform can discriminate R- and S-MA differential pulse voltammetry signals, at the voltages of 1.35 and 1.33 V (vs Ag/AgCl), respectively. To tackle the problem of highly overlapping peaks of these enantiomers, the partial least squares (PLS) regression and genetic algorithm-PLS (GA-PLS) were used for simultaneous quantification of MA enantiomers. Generally, variable selection by genetic algorithm provided an improvement in prediction results when compared to full-voltammogram PLS. Good analytical performances were obtained despite the inherent complexity of the simultaneous determination.

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Modification of platinum microelectrode with molecularly imprinted over-oxidized polypyrrole for dopamine measurement in rat striatum

Cited by 56 publications

References 53 publications

Doping Polypyrrole Films with 4-N-Pentylphenylboronic Acid to Enhance Affinity towards Bacteria and Dopamine

Doping Polypyrrole Films with 4-N-Pentylphenylboronic Acid to Enhance Affinity towards Bacteria and Dopamine

Organic Bioelectronic Tools for Biomedical Applications

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

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