Modification of pituitary-adrenal feedback sensitivity in young rats by neonatal treatment with cortisol

Erskine, Mary S.; Geller, Edward; Yuwiler, Arthur

doi:10.1530/acta.0.0960252

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…Interestingly, high endogenous Cort levels induced by maternal deprivation did not appear to be detrimental for the adrenocortical response of adult rats to stress, contrary to the effects of exogenous administration of GCs on some adrenal parameters, such as adrenal relative weight (29). Several studies that examined the effects of neonatal administration of GCs show that 20-to 25-day-old pups present lower plasma ACTH levels in response to ether and increased feedback sensitivity in response to dexamethasone, without change of Cort-binding globulin binding capacity (7). When tested at 45-48 days of age, hydrocortisonetreated female rats show decreased plasma Cort response to novelty (mild stress) and to ether (intense stress), whereas reduced Cort levels in males is seen in response to novelty, but not ether.…”

Section: Discussionmentioning

confidence: 88%

Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Suchecki

Tufik

1997

American Journal of Physiology-Regulatory, Integrative and Comp

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Twenty-four hours of maternal deprivation result in activation of the infant rat’s adrenocortical axis. In the present study we examined the long-term effects of maternal deprivation on the corticosterone (Cort) response to stress. Pups were maternally deprived (Dep) on postnatal day( PND) 11 and tested immediately ( PND 12) or returned to their mothers and tested at later ages. Testing consisted of a time course of the Cort response to a saline injection (5, 15, 30, and 60 min). At PND 12, the response of Dep pups was higher than that of nondeprived (non-Dep) pups. No group differences were observed at PND 16 and 22. On PND 30, Dep rats showed lower Cort levels than non-Dep pups at 0, 5, and 30 min after saline. At PND 60, non-Dep females showed higher Cort levels than males at 5, 15, and 30 min. This gender difference for Dep pups was observed only at 5 min. Male and female Dep animals presented lower Cort levels than non-Dep counterparts at 60 and 30 min after saline, respectively. These findings indicate that maternal deprivation effects on Cort secretion are long lasting. Dep rats showed a smaller adrenal response to stress at PND 30, whereas as adults the stress response was similar but the turnoff was different.

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Section: Discussionmentioning

confidence: 88%

Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Suchecki

Tufik

1997

American Journal of Physiology-Regulatory, Integrative and Comp

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“…This explains why authors [10,11,29] found a decrease in response to ether at 23 days of life in control-treated rats be cause they compared the response to normal rats treated with ether and not to the basal levels in the former groups. Another author [21] did not find an increase in plasma corti costerone in cortisol-treated rats after ether; in all the above experiments, plasma cortico sterone was measured by bioassay or fluorometric micromethod and Sprague-Dawley rats were used.…”

Section: Discussionmentioning

confidence: 99%

Influence of Hormones and Undernutrition on Brain Development in Newborn Rats

Pascual-Leone¹,

Escrivá²,

Álvarez³

et al. 1985

Neonatology

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High L-thyroxine (T₄) and cortisol doses given to rats during the first 8 days of life and on the first day only respectively, produce decrease of body and brain weight and perturbances to brain energy substrates, i.e. glucose and ketone bodies. The same alterations are found in the undernourished rats from the prenatal period. The pituitary GH and TSH is decreased in the T₄- and cortisol-injected animals. The plasma ACTH is decreased in the treated cortisol animals at 8, 12 and 22 days of life. The pituitary TSH content is reduced with respect to controls in the undernourished animals from 14 to 70 days of life. From the exposed experiments we suggest an alteration in the hypothalamic-pituitary complex in T₄- and cortisol-treated rats, and describe the similarities between the three experimental models.

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“…On the other hand, while neonatal dexamethasone treatment also reduces brain GR in adulthood (10), it attenuates the HPA response to stress (11, 12). Similarly, administration of the endogenous GCs, cortisol or corticosterone, in the first week of postnatal life reduces both basal and stress‐induced HPA activity in adulthood (13, 14) and may, like dexamethasone (11), augment the sensitivity of the HPA axis to GC feedback (15, 16). A substantive literature shows that early life stress also exerts profound long‐term effects on HPA function (17).…”

mentioning

confidence: 99%

Time‐Specific Effects of Perinatal Glucocorticoid Treatment on Anterior Pituitary Morphology, Annexin 1 Expression and Adrenocorticotrophic Hormone Secretion in the Adult Female Rat

John

Theogaraj

Christian

et al. 2006

J Neuroendocrinology

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Perinatal glucocorticoid (GC) treatment is increasingly associated with long-term disturbances in hypothalamo-pituitary-adrenocortical function. In the male rat, such treatment induces profound molecular, morphological and functional changes in the anterior pituitary gland at adulthood. To determine whether these effects are sex-specific, we have examined the effects of perinatal dexamethasone treatment on the female pituitary gland, focusing on (i) the integrity of the annexin 1 (ANXA1) dependent regulatory effects of GCs on adrenocorticotrophic hormone (ACTH) release and (ii) corticotroph and folliculo-stellate (FS) cell morphology. Dexamethasone was given to pregnant (gestational days 16-19) or lactating (days 1-7 post partum) rats via the drinking water (1 microg/ml); controls received normal drinking water. Pituitary tissue from the female offspring was examined ex vivo at adulthood (60-90 days). Both treatment regimes reduced the intracellular and cell surface ANXA1 expression, as determined by western blot analysis and quantitative immunogold electron microscopic histochemistry. In addition, they compromised the ability of dexamethasone to suppress the evoked release of ACTH from the excised tissue in vitro, a process which requires the translocation of ANXA1 from the cytoplasm to the cell surface of FS cells. Although neither treatment regime affected the number of FS cells or corticotrophs, both altered the subcellular morphology of these cells. Thus, prenatal dexamethasone treatment increased while neonatal treatment decreased FS cell size and cytoplasmic area. By contrast, corticotroph size was unaffected by either treatment, as also was the size of the secretory granules. Corticotroph granule density and margination were, however, increased markedly by the prenatal treatment, while the neonatal treatment had no effect on granule density but decreased granule margination. Thus, perinatal dexamethasone treatment exerts long-term effects on the female pituitary gland, altering gene expression, cell morphology and the ANXA1-dependent GC regulation of ACTH secretion. The changes are similar but not identical to those reported in the male.

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Modification of pituitary-adrenal feedback sensitivity in young rats by neonatal treatment with cortisol

Cited by 6 publications

References 17 publications

Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Influence of Hormones and Undernutrition on Brain Development in Newborn Rats

Time‐Specific Effects of Perinatal Glucocorticoid Treatment on Anterior Pituitary Morphology, Annexin 1 Expression and Adrenocorticotrophic Hormone Secretion in the Adult Female Rat

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