Modification of nanostructured materials for biomedical applications

Xu, Tao; Zhang, Ning; Nichols, Heather; Shi, Donglu; Wen, Xuejun

doi:10.1016/j.msec.2006.05.029

Cited by 129 publications

(60 citation statements)

References 188 publications

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“…To avoid stress shielding effects, it is very important that the compressive strength of the material should not exceed the strength of the surrounding bone [52]. Natural bone exhibits certain hierarchical structures of nanometer dimensions within bone matrices and so implants are of ample concern for bone repair and regeneration in biomedical applications [53]. From the results shown in Table 6 compiled from references [8,35,[54][55][56], the 0.2 CYS, UCS, and elastic modulus for the nanocomposite samples are closer to that of bone and bone tissues and could improve the interface between the nanocomposite and bone cells.…”

Section: Biomechanical Propertiesmentioning

confidence: 99%

“…Further, in these materials there is a possibility of leaching of ions by corrosion or wear, thus decreasing their biocompatibility and causing tissue loss [57]. Also, as stated in [53], mismatch in elastic modulus of bone and steels/titanium/Co-Cr alloys is likely to result in bone resorption and loosening of implants. Hence, Mg-Sm 2 O 3 nanocomposites may effectively increase the stimulation of new bone growth and re-modelling which increases the implant stability, making it favorable for applications in temporary implants avoiding stress-morbidity to the patient.…”

Section: Biomechanical Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Significantly Enhancing the Ignition/Compression/Damping Response of Monolithic Magnesium by Addition of Sm2O3 Nanoparticles

Kujur

Mallick

Manakari

et al. 2017

Metals

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Abstract:The present study reports the development of Mg-Sm 2 O 3 nanocomposites as light-weight materials for weight critical applications targeted to reduce CO 2 emissions, particularly in the transportation sector. Mg-0.5, 1.0, and 1.5 vol % Sm 2 O 3 nanocomposites are synthesized using a powder metallurgy method incorporating hybrid microwave sintering and hot extrusion. The microstructural studies showed dispersed Sm 2 O 3 nanoparticles (NPs), refinement of grain size due to the presence of Sm 2 O 3 NPs, and presence of limited porosity. Microhardness and dimensional stability of pure Mg increased with the progressive addition of Sm 2 O 3 NPs. The addition of 1.5 vol % of Sm 2 O 3 NPs to the Mg matrix enhanced the ignition temperature by~69 • C. The ability of pure Mg to absorb vibration also progressively enhanced with the addition of Sm 2 O 3 NPs. The room temperature compressive strengths (CYS and UCS) of Mg-Sm 2 O 3 nanocomposites were found to be higher without having any adverse effect on ductility, leading to a significant increase in energy absorbed prior to compressive failure. Further, microstructural characteristics are correlated with the enhancement of various properties exhibited by nanocomposites.

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Section: Biomechanical Propertiesmentioning

confidence: 99%

Section: Biomechanical Propertiesmentioning

confidence: 99%

Significantly Enhancing the Ignition/Compression/Damping Response of Monolithic Magnesium by Addition of Sm2O3 Nanoparticles

Kujur

Mallick

Manakari

et al. 2017

Metals

View full text Add to dashboard Cite

show abstract

“…2,13 Calcium phosphates are present in the form of needle-like or platelike nanocrystals with approximately 5-20 nm width and 60 nm length, which are deposited on collagen fibrils. 1,8 In fact, most nanostructured materials recently developed for bone implant, such as ceramics, polymers, and metals 14 have a more dynamic response when compared with counterpart materials with larger particle size. 15 Nanoscaled materials show improved performances due to their large surface to volume ratio and particularly high surface reactivity (unusual chemical/electronic synergistic effects).…”

Section: Introductionmentioning

confidence: 99%

Innovative macroporous granules of nanostructured‐hydroxyapatite agglomerates: Bioactivity and osteoblast‐like cell behaviour

Laranjeira

Fernandes

Monteiro

2010

J Biomedical Materials Res

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To modulate the biological response of implantable granules, two types of bioactive porous granules composed of nanostructured-hydroxyapatite (HA) agglomerates and microstructured-HA, respectively, were prepared using a polyurethane sponge impregnation and burnout method. The resulting granules presented a highly porous structure with interconnected porosity. Both types of granules were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and mercury intrusion porosimetry. Results showed that nanostructed-HA granules presented higher surface area and porosity than microstructured-HA granules. In vitro testing using MG63 human osteoblast-like cells showed that on both types of surfaces cells were able to adhere, proliferate, and migrate through the macropores, and a higher growth rate was achieved on nanostructured-HA granules than on microstructured-HA granules (76 and 40%, respectively). In addition, these cells maintained similar expression levels of osteoblastic-associated markers namely collagen type I, alkaline phosphatase, bone morphogenetic protein-2, macrophage colony-stimulating factor, and osteoprotegerin. These innovative nanostructured-HA granules may be considered as promising bioceramic alternative matrixes for bone regeneration and drug release application.

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“…In the last decade, the dramatic development of nanotechnology in material science and engineering has led to the study and the development of innovative nanostructured materials (Xu T. et al, 2007;Niemeyer, 2001;Cui & Gao, 2003;Whitesides, 2003): certain materials with delicate structures of "small" sizes, falling in the 1-100 nm range, and specific properties and functions related to the "size effect" (Safarik & Safarikova, 2002;Laval et al, 1999). In particular, extensive researches have been focused on medicine and biomedical engineering for the investigation of the interactions between nanomaterials and biological systems (Foldvari & Bagonluri, 2008;Desai, 2000).…”

Section: Carbon Nanotubes: Fascinating Nano-objectsmentioning

confidence: 99%

Carbon Nanotubes – Imprinted Polymers: Hybrid Materials for Analytical Applications

Cirillo¹,

Hampel²,

Puoci³

et al. 2012

Materials Science and Technology

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Modification of nanostructured materials for biomedical applications

Cited by 129 publications

References 188 publications

Significantly Enhancing the Ignition/Compression/Damping Response of Monolithic Magnesium by Addition of Sm2O3 Nanoparticles

Significantly Enhancing the Ignition/Compression/Damping Response of Monolithic Magnesium by Addition of Sm2O3 Nanoparticles

Innovative macroporous granules of nanostructured‐hydroxyapatite agglomerates: Bioactivity and osteoblast‐like cell behaviour

Carbon Nanotubes – Imprinted Polymers: Hybrid Materials for Analytical Applications

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