1970
DOI: 10.1111/j.2042-7158.1970.tb08475.x
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Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms

Abstract: The effects of drugs that modify adrenergic or tryptaminergic mechanisms were tested on the analgesic action of morphine in mice. Analgesia was assessed by the hot plate method and phenylquinonewrithing method. Reserpine antagonized the analgesic action of morphine in both tests, the maximal effects occurring 6–8 h after the administration of reserpine. p‐Chlorophenylalanine antagonized the analgesic action of morphine as assessed by the writhing method but not by the hot plate method. The analgesic action of … Show more

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Cited by 81 publications
(10 citation statements)
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“…1980;Larsen & Christensen 1982;Larsen & Arnt 1984). In accordance, a reduction of morphineinduced antinociception is obtained following destruction of 5-HT neurones by 5, 7 -dihydroxytryptamine (5,7-DHT), following 5-HT-synthesis inhibtion by para-chlorophenylalanine (PCPA), or following receptor blockade by 5-HT-receptor antagonists (Fennessy & Lee 1970;Yaksh eta/. 1976;Mohrland & Gebhart 1980).…”
mentioning
confidence: 87%
“…1980;Larsen & Christensen 1982;Larsen & Arnt 1984). In accordance, a reduction of morphineinduced antinociception is obtained following destruction of 5-HT neurones by 5, 7 -dihydroxytryptamine (5,7-DHT), following 5-HT-synthesis inhibtion by para-chlorophenylalanine (PCPA), or following receptor blockade by 5-HT-receptor antagonists (Fennessy & Lee 1970;Yaksh eta/. 1976;Mohrland & Gebhart 1980).…”
mentioning
confidence: 87%
“…A similar conclusion was reached by Colville & Chaplin (1964) using the rat inflamed foot as the analgesic testing method. Diminution of the analgesic activity of morphine by propranolol has been reported in the mouse (Heller, Saavedra & Fischer, 1968), but Fennessy & Lee (1970) were unable to confirm this observation.…”
Section: Discussionmentioning
confidence: 76%
“…A similar conclusion was reached by Colville & Chaplin (1964) using the rat inflamed foot as the analgesic testing method. Diminution of the analgesic activity of morphine by propranolol has been reported in the mouse (Heller, Saavedra & Fischer, 1968), but Fennessy & Lee (1970) (Collins & West, 1968) and although its actions in the brain are more complicated, Carlsson, Lindqvist, Fuxe & Hokfelt (1966) demonstrated a general fall in brain noradrenaline and a rise in dopamine in the brain stems and hemispheres of the rat. Increases in reaction time were obtained with mice pretreated with a-methyl-p-tyrosine in the presence of morphine and methylamphetamine.…”
Section: Discussionmentioning
confidence: 97%
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