Modification of monoclonal antimyosin antibody: Enhanced specificity of localization and scintigraphic visualization in acute experimental myocardial infarction

Khaw, Ban An; Torchilin, Vladimir P.; Klibanov, Alexander L.; Nossiff, Naseem; Powers, James B.; Strausś, H. William; Haber, Edgar

doi:10.1016/0022-2828(89)90835-3

Cited by 8 publications

(1 citation statement)

References 9 publications

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“…Cardiac myosin, insoluble contractile protein, which is not washed away following cell disintegration, has been used as the target antigen for specific targeting of the infracted myocardium (Khaw et al 1976(Khaw et al , 1982. Anti-myosin antibody, initially used to demonstrate sacrolemmal lesions indicative of necrotic myocyte damage (Khaw et al 1976, was also applied for the diagnostic visualization of myocardial infarction (Khaw et al 1987(Khaw et al , 1989 and for the "active targeting" of plain and long-circulating liposomes to the infarcted myocardium (Torchilin et al 1979(Torchilin et al , 1996. Cytoskeletonantigen (myosin) specific immunoliposomes (CSIL) were reported to seal cardiocyte membrane lesions by anchoring CSIL to exposed cytoskeletal antigen via the anti-myosin antibody with subsequent plugging and sealing the membrane lesions (Khudairi and Khaw 2004).…”

Section: Introductionmentioning

confidence: 99%

ATP-loaded immunoliposomes specific for cardiac myosin provide improved protection of the mechanical functions of myocardium from global ischemia in an isolated rat heart model

Verma

Levchenko

Bernstein

et al. 2006

Journal of Drug Targeting

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Earlier demonstrated cardio-protection by ATP-loaded liposomes (ATP-L) was further improved by attachment of cardiac myosin-specific monoclonal 2G4 antibody onto the surface of ATP-L. ATP-IL were infused for 1 min duration before starting the global ischemia for 25 min followed by reperfusion for 30 min in an isolated rat heart. The left ventricular developed pressure at the end of reperfusion in ATP-IL group significantly recovered to above 80% of the baseline compared to ca 25% in the Kreb's-Henseleit (KH) buffer, ca 60% in the IL, and ca 70% in the ATP-L treated groups. At the end of the reperfusion, left ventricular end diastolic pressure significantly reduced to 15 +/- 2 mmHg in ATP-IL group compared to 59 +/- 6 mmHg in the KH buffer, 31 +/- 4 mmHg in the IL and 23 +/- 3 mmHg in the ATP-L controls. The extent of preservation depended on the amount of the antibody present on the surface of the ATP-IL.

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Section: Introductionmentioning

confidence: 99%

ATP-loaded immunoliposomes specific for cardiac myosin provide improved protection of the mechanical functions of myocardium from global ischemia in an isolated rat heart model

Verma

Levchenko

Bernstein

et al. 2006

Journal of Drug Targeting

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Monoclonal antibodies used in the detection and treatment of epithelial ovarian cancer

Muto

Kassis

1995

Cancer

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Conventional therapy for epithelial ovarian cancer, including aggressive cytoreductive surgery followed by combination chemotherapy regimens, has failed to reduce the number of deaths caused by this disease, which remains the most lethal of gynecologic malignancies. Monoclonal antibodies, which offer the promise of high selectivity for detection and therapy, may be targeted to tumor‐associated antigens, growth factors, receptors, oroncogenes. They may be used alone as immunotherapeutic agents or conjugated to chemotherapeutic drugs, toxins, or radionuclides. Radioimmunoconjugates may also be used for preoperative or intraoperative tumor localization. The authors focused on the clinical utility, technical limitations, and potential of monoclonal antibodies in the detection and treatment of epithelial ovarian cancer with emphasis on radioimmunodetection and radioimmunotherapy. Cancer 1995; 76:2016‐27.

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Antimyosin Antibody Imaging in Myocardial Infarction

Bhattacharya¹,

Lahiri²

1991

Clinical Use of Antibodies

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Modification of monoclonal antimyosin antibody: Enhanced specificity of localization and scintigraphic visualization in acute experimental myocardial infarction

Cited by 8 publications

References 9 publications

ATP-loaded immunoliposomes specific for cardiac myosin provide improved protection of the mechanical functions of myocardium from global ischemia in an isolated rat heart model

ATP-loaded immunoliposomes specific for cardiac myosin provide improved protection of the mechanical functions of myocardium from global ischemia in an isolated rat heart model

Monoclonal antibodies used in the detection and treatment of epithelial ovarian cancer

Antimyosin Antibody Imaging in Myocardial Infarction

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