Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems

Abstract

The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nanosized Fe3O4 particles via classic co-precipitation method, (2) the introduction of amine groups on their surface leading to materials’ precursor, and (3) the final synthesis of branched triazine-based dendrons on the support surface by an iterative reaction between cyanuric chloride (CC) and piperazine (p) or diethylenetriamine (DETA) via nucleophilic substitution. The characterized materials were tested for their adsorptive properties towards folic acid, 18β–glycyrrhetinic acid, and vancomycin, showing high adsorption capacities varying in the ranges of 53.33–401.61, 75.82–223.71, and 68.17–132.45 mg g–1, respectively. The formed material–drug complexes were also characterized for the drug-delivery potential, performed as in vitro release studies at pH 2.0 and 7.4, which mimics the physiological conditions. The release profiles showed that the proposed materials are able to deliver up to 95.2% of the drugs within 48 h, which makes them efficient candidates for further biomedical applications.

RETRACTED ARTICLE: Magnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery

“…Furthermore, they could have a significant application in the co-delivery of hydrophobic/hydrophilic drugs for increased synergistic treatment. Over the last decades, several nano-sized and shaped dendritic scaffolds have been synthesized, which have various functionalities and applications including poly(amidoamine) (PAMAM), poly(propylene imine) (PPI), triazine, and polyester dendrimers 2,[15][16][17][18][19][20][21][22][23] .…”

Highly Efficient Separation of Ethanol Amines and Cyanides via Ionic Magnetic Mesoporous Nanomaterials

“…Initially, Fe 3 O 4 magnetic nanoparticles (MNPs) were synthesized via the co-precipitation method by FeCl 3 ·6H 2 O, FeCl 2 ·4H 2 O and NH 3 ⋅H 2 O [ 50 , 51 ]. Subsequently, the MNPs (3.0 g) were dispersed in a solution consisting of 160 mL of ethanol, 40 mL of deionized water, and 2 mL of ammonia (25%) with sufficient ultrasonic oscillation.…”

“…Each sample was measured three times and averaged to eliminate errors. [50,51]. Subsequently, the MNPs (3.0 g) were dispersed in a solution consisting of 160 mL of ethanol, 40 mL of deionized water, and 2 mL of ammonia (25%) with sufficient ultrasonic oscillation.…”

Advances in functionalization and conjugation mechanisms of dendrimers with iron oxide magnetic nanoparticles

“…Their mechanism of adsorption is realized by using both the hydroxyl and amine functional groups of the ethanolamine component, as well as the triazine amine groups, to coordinate and capture the heavy metal ions, along with utilizing electrostatic interactions. 118 (Monomers: ethanolamine-tricholorotriazine, diethanolaminetriazine, diethylenetriamine-triazine and cyanuric chloride-tri- azine, 117 triethanolamine-melamine with carbon disulfide bridges, etc.) Ref.…”

“…Functionalization of MNPs with triazine dendrimers can be achieved through different methods, such as covalent conjugation or electrostatic adsorption. 117 Their performance was impressive in terms of attaching to metal ions Pb( ii ) and Cd( ii ), with a strong ability to filter these contaminants from water-based substances (with an efficiency of 93.6% and 98.5%, respectively). Their mechanism of adsorption is realized by using both the hydroxyl and amine functional groups of the ethanolamine component, as well as the triazine amine groups, to coordinate and capture the heavy metal ions, along with utilizing electrostatic interactions.…”