Modification of Lipoproteins in Diabetes

Lopes‐Virella, Maria F.; Klein, Richard L.; Virella, Gabriel

doi:10.1002/(sici)1099-0895(199603)12:1<69::aid-dmr156>3.0.co;2-b

Cited by 14 publications

(11 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative modification of LDL results in rapid uptake by macrophages, which leads to foam cell formation and promotion of the expression of intercellular adhesion molecule-1 [45]. Furthermore, LDL oxidation in the postprandial state seems to be affected by an acute increase in glycemia.…”

Section: Postprandial Lipoproteins and Cvd Risks In Diabetic Populationsmentioning

confidence: 99%

Postprandial Lipoproteins and Cardiovascular Disease Risk in Diabetes Mellitus

et al. 2010

View full text Add to dashboard Cite

Diabetes mellitus is associated with increased risk for atherosclerotic cardiovascular disease (CVD). Recent prospective studies in healthy individuals suggest that the postprandial triglyceride (TG) level is a better independent predictor for assessing future CVD events than fasting TG levels. In contrast, results have been more controversial among diabetic patients, as some studies report a positive association between postprandial TG and CVD. This raises the issue of to what extent postprandial TG levels may be of predictive value in the diabetic population. One possibility impacting on the predictive power of postprandial TG in identifying CVD risk may be the presence of other risk factors, including alterations in lipid and lipoprotein metabolism, which could make it more difficult to identify the impact of postprandial lipemia on cardiovascular risk. The findings provide a challenge to develop a better approach to assess the impact of postprandial lipemia on CVD risk under diabetic conditions.

show abstract

Section: Postprandial Lipoproteins and Cvd Risks In Diabetic Populationsmentioning

confidence: 99%

Postprandial Lipoproteins and Cardiovascular Disease Risk in Diabetes Mellitus

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Elevated concentrations of blood glucose and serum lipids are risk factors in the development of arteriosclerosis in diabetes mellitus (Lopes-Virella et al, 1996;Mironova et al, 2000). As the potential basis of a new antidiabetic drug, L. ovalifolia clearly merits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract ofLaportea ovalifolia(Urticaceae), measured in rats with alloxan-induced diabetes

Momo¹,

Oben²,

Tazoo³

et al. 2006

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

A decoction of the leaves of Laportea ovalifolia is widely used in Cameroon for the treatment of several illnesses, including diabetes mellitus. The antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of the aerial parts of L. ovalifolia have now been investigated, in normal rats and rats with diabetes induced by the intraperitoneal injection of alloxan (at 150 mg/kg bodyweight). In the diabetic rats, 2 weeks of daily, intragastric treatment with the L. ovalifolia extract not only produced a significant reduction in the fasting serum glucose concentrations but also lowered the serum concentrations of total cholesterol, triglycerides, and low-density-lipoprotein cholesterol, lowered the ratio of total cholesterol to high-density-lipoprotein (HDL) cholesterol, and increased the serum concentration of HDL cholesterol. At least in rats with alloxan-induced diabetes, the methanol/methylene-chloride extract of L. ovalifolia therefore appears to possess antidiabetic and hypolipidaemic properties.

show abstract

“…We have shown that LDL-IC metabolised by phagocytic cells (30) can activate the cell (29) which results in increased release of matrix metalloproteinases and pro-inflammatory cytokines which can contribute to unstable plaques and vascular inflammation, respectively (4). LDL-IC metabolism by phagocytic cells also leads to cholesteryl ester accumulation in the cell (1) which may be sufficient to result in foam cell formation. Collectively, these processes may both contribute to macrovascular disease in diabetes.…”

Section: Figures and Tablesmentioning

confidence: 99%

“…Enhanced oxidative stress and dyslipoproteinemia have been proposed as significant factors contributing to the accelerated development of macrovascular complications in diabetes (1–3). Multiple lines of evidence support the role of immune complexes containing modified LDL (LDL-IC) in inflammation and in atherosclerosis in diabetes (4).…”

Section: Introductionmentioning

confidence: 99%

LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Klein

Carter

Jenkins

et al. 2011

Journal of Diabetes and its Complications

Self Cite

View full text Add to dashboard Cite

Immune complexes containing modified LDL (LDL-IC) and NMR-determined total LDL particle concentrations are significantly associated with intima-medial thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; p<0.01) and with Small LDL concentration (r=0.22, r=0.13, respectively; p<0.01). In women, Large LDL concentrations were also associated with LDL-IC (r=0.20, p<0.01) while in men, the association was more modest (r=0.11, p<0.05). Thus, both Small and Large LDL are associated with LDL-IC formation. Based on the results from statistical mediation analyses, we concluded that plasma concentrations of LDL-IC may provide a physiological link between the statistically significant association of Total LDL particle concentration with carotid artery intima-media thickness in subjects with Type 1 diabetes. Furthermore, after adjusting for conventional risk factors, there was a decrease in LDL-IC concentration even in the presence of high Total LDL particle concentrations in those women with high concentrations of Large HDL but the association was not evident in men. This suggests that the associations between Large HDL and Total LDL particle concentrations, and their associations with LDL-IC levels, differ by gender and suggest that LDL-IC partially mediates the contribution of Total LDL particle concentration to increased carotid IMT in diabetic men.

show abstract

Modification of Lipoproteins in Diabetes

Cited by 14 publications

References 170 publications

Postprandial Lipoproteins and Cardiovascular Disease Risk in Diabetes Mellitus

Postprandial Lipoproteins and Cardiovascular Disease Risk in Diabetes Mellitus

Antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract ofLaportea ovalifolia(Urticaceae), measured in rats with alloxan-induced diabetes

LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Contact Info

Product

Resources

About