Modification of IκBα by taurine bromamine inhibits tumor necrosis factor α-induced NF-κB activation

Tokunaga, Shinichi; Kanayama, Atsuhiro; Miyamoto, Yusei

doi:10.1007/s00011-007-7016-3

Cited by 21 publications

(25 citation statements)

References 45 publications

(37 reference statements)

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“…Lower density housing and increased exercise may moderate these physiopathological processes. Taurine has the ability to regulate the inflammatory process in vivo by inhibiting NF-κB activation (Tokunaga et al, 2007). In the current study, the DNA-binding activity of NF-κB, TNF-α mRNA, and activity of iNOs were significantly decreased by taurine supplementation.…”

Section: Discussionmentioning

confidence: 85%

The influence of dietary taurine and reduced housing density on hepatic functions in laying hens

Zhi-gang

Zhang

et al. 2014

Poultry Science

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To investigate the influence of dietary taurine and reduced housing density on hepatic functions in laying hens, green-shell laying hens were randomly assigned to 3 groups: a free-range group, a caged group with low-density, and a caged group with high-density. Each group was further divided into the control (C) and taurine-treatment (T) groups. All the test birds were fed the same basic diet, except that the T groups were supplemented with 0.1% taurine. After 15 d, sera and liver were aseptically collected. The results show that dietary taurine supplementation and reduced housing density significantly attenuated physiopathological changes in the liver. When compared with the free-range group, serum alanine aminotransterase and aspartate aminotransterase in the caged hens were significantly higher and were deceased by taurine (P< 0.05). Serum inducible nitric oxide synthase activity in caged hens was higher than that in free-range hens, and taurine reduced serum inducible nitric oxide synthase activities in the low-density group (P < 0.05). Nuclear factor-κB DNA-binding activity increased significantly in the high-density housing group when compared with the other 2 housing patterns and was decreased by taurine (P < 0.05). Taurine reduced the expression of tumor necrosis factor-α mRNA in all 3 rearing patterns, IL-4 mRNA expression in the high-density group, and IL-10 in the low-density group (P < 0.05). Malondialdehyde levels decreased in serum and liver from T groups and serum total antioxidation capability levels increased significantly (P < 0.05) in the low-density group. Dietary taurine supplementation decreased acetyl-CoA and sterol regulatory element-binding protein-1c mRNA expression in the high-density groups (P < 0.05). Taurine significantly increased lipoprotein lipase mRNA expression in the high-density group and peroxisome proliferator receptor mRNA expression both in the low- and high-density groups (P < 0.05). Taurine supplementation reduced total cholesterol levels in the low- and high-density groups, decreased triglyceride and low-density lipoprotein cholesterol levels in high-density groups, and increased high-density lipoprotein cholesterol levels in all 3 rearing patterns (P < 0.05). Our data demonstrate that dietary taurine and reduced housing density offer significant protection from hepatic damage in laying hens.

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Section: Discussionmentioning

confidence: 85%

The influence of dietary taurine and reduced housing density on hepatic functions in laying hens

Zhi-gang

Zhang

et al. 2014

Poultry Science

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“…The stock solutions of HOCl (100 mM) were prepared in water. Stock solutions of hypobromous acid (HOBr) 100 mM were synthesised by combining 100 mM HOCl and 200 mM NaBr in water [22]. Stock solutions of taurine bromamine (Tau-NHBr) were prepared immediately prior to use by the addition of 5 mM HOBr to 500 mM taurine in 10 mM phosphate buffer at pH 7.0 [23].…”

Section: Chemicals and Solutionsmentioning

confidence: 99%

Albumin-induced circular dichroism in Congo red: Applications for studies of amyloid-like fibril aggregates and binding sites

Vasconcelos

Ximenes

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The TIR domain interacts with myeloid differentiation primary response protein 88 (MyD88), TIR-domain-containing adapter-inducing interferon-β (TRIF) and TRIF-related adaptor molecule (TRAM) to initiate signaling which ultimately induces the expression of numerous immune response genes through activation of activator protein (AP)-1, nuclear factor kappa B (NF-κB) and other transcription factors [18,19]. Taurine has the ability to regulate the inflammatory process in vivo by inhibiting the activation of NF-κB and thus inhibiting the generation of proinflammatory cytokines [20]. To our knowledge, the relationship between taurine regulation of the inflammatory process and the changes in TLRs has not been defined.…”

Section: Introductionmentioning

confidence: 99%

The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-κB) signaling pathway in Streptococcus uberis-induced mastitis in rats

Miao

Zheng

Zhang

et al. 2011

International Immunopharmacology

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Modification of IκBα by taurine bromamine inhibits tumor necrosis factor α-induced NF-κB activation

Abstract: TauBr was found to be highly membrane-permeable. TauBr might be generated both extracellularly and intracellularly by eosinophils at inflammatory sites in allergic disease and play an anti-inflammatory role.

Cited by 21 publications

References 45 publications

The influence of dietary taurine and reduced housing density on hepatic functions in laying hens

The influence of dietary taurine and reduced housing density on hepatic functions in laying hens

Albumin-induced circular dichroism in Congo red: Applications for studies of amyloid-like fibril aggregates and binding sites

The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-κB) signaling pathway in Streptococcus uberis-induced mastitis in rats

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