Modification of immune response by low dose ionizing radiation: role of apoptosis

Shankar, Bhavani S.; Premachandran, Sudha; Bharambe, S.D.; Sundaresan, Periasamy; Sainis, Krishna B.

doi:10.1016/s0165-2478(99)00074-7

Cited by 35 publications

(29 citation statements)

References 25 publications

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“…Shankar et al indicated that the modification of immune response by radiation was different between BALB/c and C57BL/6 mice. 30) Thirdly, it would be supposed that irradiation might have an immunostimulatory effect on diseases involving impaired immunity, such as cancer and severe autoimmune disease (e.g., MRL-lpr/lpr mice), [31][32][33][34][35] while exacerbating the response in immune hypersensitivity diseases, such as asthma.…”

Section: Discussionmentioning

confidence: 99%

Effect of Repeated Small-Dose .GAMMA.-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice

Fang

Muto

Tago

et al. 2006

JOURNAL OF HEALTH SCIENCE

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We previously showed that several small-dose 0.5 Gy whole-body γ-ray irradiation inhibits tumor growth in mice via elevation of the interferon (IFN)-γ/interleukin 4 (IL-4) ratio concomitantly with a decrease in the percentage of B cells. Here, we examined whether repeated small-dose (0.5 Gy, 10 times) γ-ray irradiation influences atopic dermatitis in an NC/Nga mouse model. It was found that repeated γ-ray irradiation increased total IgE in comparison with the disease-control group. Levels of IL-4 and IL-5 were increased versus the disease-control group, while IFN-γ was slightly decreased, resulting in a further decrease of the IFN-γ/IL-4 ratio compared with the disease-control group. These results indicate that repeated small-dose γ-ray irradiation may exacerbate atopic dermatitis. This may be because the irradiation induces not helper T lymphocyte 1 (Th1), but Th2 polarization in this atopic mouse model, i.e., the effects of small-dose irradiation may be different in conditions involving immune hypersensitivity and impaired immunity.

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Section: Discussionmentioning

confidence: 99%

Effect of Repeated Small-Dose .GAMMA.-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice

Fang

Muto

Tago

et al. 2006

JOURNAL OF HEALTH SCIENCE

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“…The apoptotic response of thymocytes after low-dose irradiation of the thymus can be measured by counting apoptotic bodies, which are used to assess DNA fragmentation [16]. These mechanisms are partly explained by an increased expression of the pro-apoptosis gene p53 in irradiated lymphocytes [17]. The immunological alterations determine even the distribution and function of certain circulating B and T cell subspecies and can be measured in the peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Short-term preoperative radiotherapy in rectal cancer patients leads to a reduction of the detectable number of lymph nodes in resection specimens

Maschuw

Kress

Ramaswamy

et al. 2006

Langenbecks Arch Surg

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We conclude that a 5x5 Gy short-term preoperative radiotherapy leads to a reduction in the number of lymph nodes in TME/PME specimens. Because neoadjuvant therapy in rectal cancer for T(2) and T(3) tumors has advanced a new therapeutic standard procedure, in the future, less lymph nodes will be detected in TME/PME specimens. This might influence the required number of lymph nodes in current staging systems for rectal cancer in the future.

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“…Gupta et al [20] also have not shown significant differences in the percentage of CD5+CD19+ and CD5+CD19+/ CD19+ cell ratio in normal peripheral blood with reference to age groups below 40 and over 40 years of age (range: 23-69 years). The observed decrease in B1 cells percentage may result from apoptosis or immunoregulatory processes among these cells, associated with the induction of free radicals and lower activity of antioxidant enzymes observed in X-ray department workers [21][22][23]. Moreover, Torkabadi et al [24] have observed higher percentages of CD4+CD25+ cells (regulatory T cells) in angiography personnel exposed to LLIR, which may have suppressive influence on B cells proliferation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of selected B cells populations in the workers of X-ray departments

Kłuciński

Mazur

Sędek

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: Workers of X-ray departments are occupationally exposed to long-term low levels of ionizing radiation (LLIR), which may affect their humoral immunity. The aim of the study was to assess the influence of LLIR on the number and proportion of B cells (CD19+), B1 cells (CD5+CD19+) and memory B cells (CD27+CD19+) in peripheral blood of such workers. Materials and Methods: In the study group of 47 X-ray departments workers and the control group consisting of 38 persons, the number and percentage of CD19+, CD5+CD19+, CD27+CD19+ cells as well as CD5+CD19+/CD19+ and CD27+CD19+/CD19+ cell ratios were assessed using flow cytometry. Additionally, the study group was divided into 2 groups by the length of employment below and over 15 years and analysis adjusted for age and smoking habit was performed. Results: The total number of CD19+ cells showed significant increase in the group of workers in comparison with the persons from the control group, whereas the percentage of CD5+CD19+ cells as well as CD27+CD19+/CD19+ and CD5+CD19+/CD19+ cell ratios were lower. Percentage, number of CD5+CD19+ cells and CD5+CD19+/CD19+ cell ratio were significantly lower in the workers with length of employment longer than 15 years in comparison with those employed below 15 years. Moreover, we found positive associations between the number of CD19+ cells and employment as well as smoking habit, whereas the number of CD5+CD19+ cells was positively associated with cigarette smoking alone. Percentage of CD5+CD19+ cells as well as CD5+CD19+/CD19+ and CD27+CD19+/CD19+ cell ratios were negatively correlated with employment. Conclusions: The study suggests association between the suppressive influence of low level ionizing radiation on circulating in peripheral blood, especially of B1 cells as well as of memory B cells, in workers of X-ray units, which is adverse in relation to microbiological threat.

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Modification of immune response by low dose ionizing radiation: role of apoptosis

Cited by 35 publications

References 25 publications

Effect of Repeated Small-Dose .GAMMA.-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice

Effect of Repeated Small-Dose .GAMMA.-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice

Short-term preoperative radiotherapy in rectal cancer patients leads to a reduction of the detectable number of lymph nodes in resection specimens

Assessment of selected B cells populations in the workers of X-ray departments

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