Modification of Hypothalamic- Pituitary-Adrenocortical Activity by Serotonergic Agents in the Rat

Matheson, Keith; Knowles, Andrew; Gage, Deanna; Michel, Carla; Guthrie, Deanne; Bauer, Christopher; Blackbourne, Jamie L.; Weinzapfel, Dan

doi:10.1159/000139513

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…In fact, when we initially reported that N/OFQ increases circulating ACTH and CORT concentrations in unstressed and mildly stressed rats (Devine et al, 2001), we reconciled our hormonal findings with the published behavioral data (Jenck et al, 1997;Griebel et al, 1999) on the basis that a variety of drugs that are anxiolytic can also increase circulating CORT concentrations in unstressed or mildly stressed rats (Ellis, 1966;Kakihana et al, 1968;Marc and Morselli, 1969;Tabakoff et al, 1978;Rivier et al, 1984;Matheson et al, 1988Matheson et al, , 1997ade Boer et al, 1991). However, the current findings indicate that the behavioral and hormonal effects of N/OFQ resemble the effects of drugs like FG 7142 File, 1985, 1986), yohimbine (Smythe et al, 1983;Suemaru et al, 1989), amphetamine (Knych and Eisenberg, 1979;, and caffeine (Spindel et al, 1983;Fall of which are anxiogenic in neophobic tests of anxiety, and all of which elevate circulating ACTH and/or CORT concentrations after acute administration.…”

Section: Anxiogenic Action Of N/ofqsupporting

confidence: 52%

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Fernandez

Misilmeri

Felger

et al. 2003

Neuropsychopharmacol

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Intracranial administration of nociceptin/orphanin FQ (N/OFQ) increases circulating concentrations of adrenocorticotrophic hormone and corticosterone in unstressed rats, and elevates the responsiveness of these hormones during mild stress. Furthermore, N/OFQ and its cognate receptor are both abundant in a variety of limbic nuclei, and stress exposure decreases neuronal N/OFQ content in forebrain neurons. In light of these and other findings, we examined the potential involvement of N/OFQ in regulation of anxiety-related behaviors in rats. In the open field, elevated plus maze, and dark-light neophobic tests, intracerebroventricular N/OFQ (1.0 pmole-1.0 nmole) increased the expression of anxiety-related behaviors. Specifically, N/OFQ increased the latency to enter, decreased the number of entries into, and decreased the time spent in the exposed or brightly lit environments of all three tests. N/OFQ also enhanced thigmotactic responses in the open field test. The effects of diazepam and of the benzodiazepine inverse agonist FG 7142 were also assessed in independent groups of rats. In all three tests, the behavioral effects of N/OFQ resembled the anxiogenic actions of FG 7142, and contrasted with the anxiolytic actions of diazepam. N/OFQ administration also increased circulating concentrations of corticosterone during anxiety testing, in comparison with the concentrations in vehicle-treated controls. We conclude that N/OFQ administration is anxiogenic, and elevates responsiveness of the hypothalamic pituitary-adrenal axis during neophobic tests of anxiety. This supports the possibility that N/OFQ neurotransmission participates in processing of emotionally-salient and stressful stimuli, and suggests that normal functioning of the N/OFQ system may be important in physiological and psychological well-being.

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Section: Anxiogenic Action Of N/ofqsupporting

confidence: 52%

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Fernandez

Misilmeri

Felger

et al. 2003

Neuropsychopharmacol

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Neurochemical Systems Regulating the Hypothalamo-Pituitary-Adrenocortical Axis

Herman¹,

Figueiredo²,

Mueller³

et al. 2007

Handbook of Neurochemistry and Molecular Neurobiology

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Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo

Sullivan

Crane

Damjanoska

et al. 2005

Naunyn-Schmiedeberg's Arch Pharmacol

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Tandospirone, an azapirone, is a selective serotonin(1A) (5-HT(1A)) receptor agonist. The effects of tandospirone on plasma hormones and on mitogen-activated protein (MAP) kinase activity in the brain of male rats were studied. Tandospirone produced a time- and dose-dependent increase in plasma levels of oxytocin, adrenocorticotropin (ACTH), corticosterone, and prolactin. The minimal dose of tandospirone that led to a significant elevation of plasma oxytocin, ACTH, and prolactin levels was 1.0 mg/kg (s.c.), while the minimal dose for corticosterone release was 3.0 mg/kg (s.c.). The ED(50) of tandospirone was 1.3 mg/kg for oxytocin, 1.2 mg/kg for ACTH, 3.0 mg/kg for corticosterone, and 0.24 mg/kg for prolactin. Pretreatment with the specific 5-HT(1A) receptor antagonist WAY 100,635 (0.3 mg/kg, s.c.) completely blocked the effects of tandospirone on plasma levels of oxytocin, ACTH, and corticosterone but shifted the dose-response curve for prolactin to the right. Tandospirone injection (10 mg/kg, s.c.) stimulated the MAP kinase signaling cascade, specifically the phosphorylation of p42/44 extracellular signal-regulated kinase (ERK). Western blot analysis revealed a significant increase in phosphorylated ERK (p-ERK) levels in the hypothalamic paraventricular nucleus (PVN) as well as the dorsal raphe nucleus 5 min following tandospirone injection. These increases were blocked by pretreatment with WAY 100,635 (0.3 mg/kg). The results are the first evidence that systemic 5-HT(1A) receptor agonist administration produces a rapid increase in p-ERK levels in vivo, providing further insight into the signaling mechanisms of the 5-HT(1A) receptor.

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Modification of Hypothalamic- Pituitary-Adrenocortical Activity by Serotonergic Agents in the Rat

Cited by 9 publications

References 13 publications

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Nociceptin/Orphanin FQ Increases Anxiety-Related Behavior and Circulating Levels of Corticosterone During Neophobic Tests of Anxiety

Neurochemical Systems Regulating the Hypothalamo-Pituitary-Adrenocortical Axis

Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo

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