Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle
Nadide Aydin,
Bouchra Ouliass,
Guylaine Ferland
et al.
Abstract:The TAM receptor ligand Gas6 is known for regulating inflammatory and immune pathways in various organs including the brain. Gas6 becomes fully functional through the post-translational modification of multiple glutamic acid residues into γ-carboxyglutamic in a vitamin K-dependent manner. However, the significance of this mechanism in the brain is not known. We report here the endogenous expression of multiple components of the vitamin K cycle within the mouse brain at various ages as well as in distinct brain… Show more
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