Modification of gamma radiation induced response of peritoneal macrophages and splenocytes by<i>Hippophae rhamnoides</i>(RH-3) in mice

Prakash, Hridayesh; Bala, Madhu; Ali, Arlene Asthana; Goel, Harish Chandra

doi:10.1211/0022357056668

Cited by 15 publications

(11 citation statements)

References 29 publications

(26 reference statements)

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“…There was a small but reproducible amount of LTE 4 , suggesting that a small number of cells in the peritoneal cavity of WT animals survived irradiation and remained able to generate cysLTs. It has been reported that macrophages and mast cells are relatively radioresistant (30,31). Compared to the robust restoration of LT synthesis in the chimeric animals described above, these experiments with 5LO Ϫ/Ϫ bone marrow provide solid support for the hypothesis that the overwhelming majority of LTA 4 generated during zymosan-induced peritonitis in the mouse is derived from bone marrow hematopoietic cells.…”

Section: Generation Of Leukotrienes In Chimeric Micesupporting

confidence: 60%

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

Zarini

Gijón

Ransome

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Leukotrienes (LTs) are lipid mediators of inflammation formed by enzymatic oxidation of arachidonic acid. One intriguing aspect of LT production is transcellular biosynthesis: cells expressing 5-lipoxygenase (5LO) form LTA4 and transfer it to cells expressing LTA4 hydrolase (LTA4H) or LTC4 synthase (LTC4S) to produce LTB4 or LTC4. This process has been demonstrated in vivo for LTB4, but not for cysteinyl LTs (cysLTs). We examined transcellular cysLT synthesis during zymosan-induced peritonitis, using bone marrow transplants with transgenic mice deficient in key enzymes of LT synthesis and analyzing all eicosanoids by liquid chromatography/ tandem mass spectrometry. WT mice time-dependently produced LTB4 and cysLTs (LTC4, LTD4, and LTE4). 5LO ؊/؊ mice were incapable of producing LTs. WT bone marrow cells restored this biosynthetic ability, but 5LO ؊/؊ bone marrow did not rescue LT synthesis in irradiated WT mice, demonstrating that bone marrow-derived cells are the ultimate source of all LTs in this model. Total levels of 5LO-derived products were comparable in LTA4H ؊/؊ and WT mice, but were reduced in LTC4S ؊/؊ animals. No differences in prostaglandin production were observed between these transgenic or chimeric mice. Bone marrow cells from LTA 4H ؊/؊ or LTC4S ؊/؊ mice injected into 5LO ؊/؊ mice restored the ability to synthesize LTB4 and cysLTs, providing unequivocal evidence of efficient transcellular biosynthesis of cysLTs. These results highlight the potential relevance of transcellular exchange of LTA 4 for the synthesis of LTs mediating biological activities during inflammatory events in vivo. chimeric mice ͉ leukotriene B4 ͉ mass spectrometry ͉ leukotriene E4 ͉ 5-lipoxygenase

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Section: Generation Of Leukotrienes In Chimeric Micesupporting

confidence: 60%

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

Zarini

Gijón

Ransome

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…These experiments examined the levels of various biomarkers of oxidative stress, including superoxide anion, lipid peroxidation, and protein oxidation. Interestingly, RH-3 was found to have immunostimulatory properties, which may play an important role in its radioprotective efficacy (Prakash et al, 2005 ).…”

Section: Radioprotective Ability Of Sea Buckthornmentioning

confidence: 99%

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

2018

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Various parts of sea buckthorn [Elaeagnus rhamnoides (L.) A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a “golden mean” for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and animal in vivo studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.

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“…To improve the digestibility of food and food intake, natural food additives are commonly used for raising animals (Fang et al, 2008). Studies have shown that plant extracts can improve food intake and food digestibility in ruminants (Prakash et al, 2010;Velagapudi et al, 2010). The leaf and fruit of sea-buckthorn can improve the average daily gain and feed conversion in monogastric animals (Zhao et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

Liu¹,

Niu²,

Tang³

et al. 2019

SA J. An. Sci.

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In this study, the effects of sea-buckthorn (Hippophae rhamnoides L.) leaves (SL) on the biochemical parameters and metabolomic profiling in Altay lamb (Ovis aries) were observed. Sixty six-month-old male Altay lambs (body weight 28.0 ± 3.5 kg) were randomly assigned to four groups (n=15). The experimental groups were named as CON, 2.5%, 5.0% and 7.5%. The group CON, contained animals fed with a basal diet. Animals of the other groups were fed a treatment diet consisting of 2.5% (Group 2.5%), 5.0% (Group 5.0%) and 7.5% (Group 7.5%) SL. The experimental period lasted 56 days. The results showed that the average daily gain (ADG) and average daily feed intake (ADFI) increased with the increase in the levels of dietary SL. Dietary SL showed a direct relationship with total protein (TP), albumin, globulin and total cholesterol (TC) content of the experimental animals. However, an indirect relationship was observed between dietary SL and the concentration of urea nitrogen (UN). The concentrations of glucose, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) showed quadratic change. Additional changes occurred in the endogenous metabolites involving multiple pathways. The pathways were tricarboxylic acid (TCA) cycle, the metabolism of protein and amino acid and the metabolism of fatty acid and steroid. The changes in metabolites primarily revealed an increase in amino acids and carbohydrates and a decrease in lipid metabolites. These findings provide a comprehensive insight into the effects of the metabolic aspects of sea-buckthorn leaves on Altay lambs. In addition, the present research results provide a better understanding to the development and utilization of sea-buckthorn as a healthy additive for small ruminant production.

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Modification of gamma radiation induced response of peritoneal macrophages and splenocytes byHippophae rhamnoides(RH-3) in mice

Cited by 15 publications

References 29 publications

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

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