Modification of DNA-templated conductive polymer nanowires via click chemistry

Hannant, Jennifer; Hedley, John; Pate, Jonathan; Walli, Adam; Al-Said, Said A. Farha; Galindo, Miguel A.; Connolly, Bernard A.; Horrocks, Benjamin R.; Houlton, Andrew; Pike, Andrew R.

doi:10.1039/c0cc00693a

Cited by 40 publications

(30 citation statements)

References 20 publications

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“…Co., and were used as received. Pentafluorophenyl acrylate (PFA) and 3‐azidopropylamine were prepared according to the methods reported in the literature …”

Section: Methodsmentioning

confidence: 99%

PEGylated Metalloporphyrin Nanoparticles as a Promising Catalyst for the Heterogeneous Oxidation of Cyclohexene in Water

Chen

Qian

et al. 2014

Macro Chemistry & Physics

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Amphiphilic poly[poly(ethylene glycol) methyl ether methacrylate]-b -poly(azidopropyl acrylamide) (PPEGMEMA-b -PAzPA) block copolymers are synthesized via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and a reactive ester-amine reaction. The azido-functionalized PPEGMEMA-b -PAzPA block copolymers can self-assemble into polymeric micelles in an aqueous medium and encapsulate hydrophobic alkynyl-containing manganese(III)porphyrin (MnP) within the core domain. The subsequent in situ copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) leads to the formation of PEGylated-MnP nanoparticles (PEG-MnP NPs). The as-synthesized PEG-MnP NPs are explored as a heterogeneous catalyst for oxidation of cyclohexene in water. The effect of various parameters, such as precursor oxidants, substrate to catalyst loading ratio, and presence of a cocatalyst, is investigated to optimize the oxidation conditions. The catalytic activity of PEG-MnP NPs in water is also compared with that of dissolved MnP in organic solvent.

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“…Co., and were used as received. Pentafluorophenyl acrylate (PFA) and 3‐azidopropylamine were prepared according to the methods reported in the literature …”

Section: Methodsmentioning

confidence: 99%

PEGylated Metalloporphyrin Nanoparticles as a Promising Catalyst for the Heterogeneous Oxidation of Cyclohexene in Water

Chen

Qian

et al. 2014

Macro Chemistry & Physics

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“…This method has been used to incorporate alkynyl groups to enhance the nucleation of subsequent Ag layers, 48 or to allow the functionalisation of the NWs by the copper-catalysed azide-alkyne Huisgen cycloaddition, 'click', reaction. 49 2 Structure of DNA-templated nanowires and the mechanism of templating The details of the mechanism of DNA-templating are of fundamental interest, but also have signicance for the major proposed applications of NWs as interconnects in electronic devices and as transducing elements in chemical sensors. In the case of interconnects, it is clearly desirable for the NWs to be uniform and continuous to attain the maximum possible conductivity.…”

Section: Conductive Polymersmentioning

confidence: 99%

DNA-templated nanowires: morphology and electrical conductivity

et al. 2014

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DNA-templating has been used to create nanowires from metals, compound semiconductors and conductive polymers. The mechanism of growth involves nucleation at binding sites on the DNA followed by growth of spherical particles and then, under favourable conditions, a slow transformation to a smooth nanowire. The final transformation is favoured by restricting the amount of templated material per unit length of template and occurs most readily for materials of low surface tension. Electrical measurements on DNA-templated nanowires can be facilitated using three techniques: (i) standard current-voltage measurements with contact electrodes embedded in a dielectric so that there is a minimal step height at the dielectric/electrode boundary across which nanowires may be aligned by molecular combing, (ii) the use of a dried droplet technique and conductive AFM to determine contact resistance by moving the tip along the length of an individual nanowire and (iii) non-contact assessment of conductivity by scanned conductance microscopy on Si/SiO2 substrates.

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“…[33] Additionally,t he DNA template can guide the polymerization of monomers to produce uniformly decorated materialst op rovidee venly spacedn ucleation sites for metal ion deposition to improveD NA wire properties. [34] Long DNA strandsc ontaining high copy numbers( up to 10 kbp) of short repeats equences (2-3 nucleotides)a re readily synthesised from 10-20 mer duplex oligonucleotides using isothermals lippage methods. [17,35] Although isothermal slippage has been shown to occur for 6-10 bp repeats such as telomeric sequences, [36] we have found that intermediate sized repeat sequences (4-40 nucleotides)a re most efficiently extended by thermalc ycling methods.…”

Section: Introductionmentioning

confidence: 99%

Self‐Priming Enzymatic Fabrication of Multiply Modified DNA

Whitfield

Little

Khan

et al. 2018

Chemistry A European J

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The self-priming synthesis of multiply modified DNA by the extension of repeating unit duplex "oligoseeds" provides a source of versatile DNA. Sterically-demanding nucleotides 5-Br-dUTP, 7-deaza-7-I-dATP, 6-S-dGTP, 5-I-dCTP as well as 5-(octadiynyl)-dCTP were incorporated into two extending oligoseeds; [GATC] /[GATC] and [A G] /[CT ] . The products contained modifications on one or both strands of DNA, demonstrating their recognition by the polymerase as both template (reading) and substrate (writing). Nucleobase modifications that lie in the major groove were reliably read and written by the polymerase during the extension reaction, even when bulky or in contiguous sequences. Repeat sequence DNA over 500 bp long, bearing four different modified units was produced by this method. The number, position and type of modification, as well as the overall length of the DNA can be controlled to yield designer DNA that offers sequence-determined sites for further chemical adaptations, targeted small molecule binding studies, or sensing and sequencing applications.

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Modification of DNA-templated conductive polymer nanowires via click chemistry

Abstract: DNA templated nanowires of a pentynyl-modified poly2-(2-thienyl)-pyrrole undergo functionalisation via"click chemistry" and retain their 1D-nanostructure and conductive properties.

Cited by 40 publications

References 20 publications

PEGylated Metalloporphyrin Nanoparticles as a Promising Catalyst for the Heterogeneous Oxidation of Cyclohexene in Water

PEGylated Metalloporphyrin Nanoparticles as a Promising Catalyst for the Heterogeneous Oxidation of Cyclohexene in Water

DNA-templated nanowires: morphology and electrical conductivity

Self‐Priming Enzymatic Fabrication of Multiply Modified DNA

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