Modification of collagen with proanthocyanidins by mimicking the bridging role of glycosaminoglycans for dentine remineralization

Zhang, Ye; Huang, Ying; Pang, Yanyun; Zhu, Zihui; Zhang, Yuchen; Liu, Qing; Zhang, Xu; Liu, Ying

doi:10.1016/j.matdes.2021.110067

Cited by 9 publications

(7 citation statements)

References 56 publications

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“…Incorporation of grape seed proanthocyanidins into dental adhesives can promote the enzymatic resistance of collagen at the dentin/adhesive interface and significantly prolong the degradation period of collagen fibers [ 128 ]. PAs also showed significant inhibition and anti-adhesion against principal cariogenic bacteria (Streptococcus mutans and Lactobacillus acidophilus) [ 130 ] and microorganisms causing oral infections ( Enterococcus faecalis , Porphyromonas gingivalis , and Clostridium difficile ) [ 131 , 132 ]. In addition, oligomeric proanthocyanidins (OPCs) released from dentin can induce differentiation of dental pulp cells (DPC) to a phenotype favoring biomineralization [ 133 ].…”

Section: Absorbable Barrier Membranementioning

confidence: 99%

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Ren

Fan

Alkildani³

et al. 2022

IJMS

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Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. This work provides a comparative summary of common barrier membranes used in GBR, focusing on recent advances in collagen membranes and their biological mechanisms. In conclusion, the review article highlights the biological and regenerative properties of currently available barrier membranes with a particular focus on bioresorbable collagen-based materials. In addition, the advantages and disadvantages of these biomaterials are highlighted, and possible improvements for future material developments are summarized.

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Section: Absorbable Barrier Membranementioning

confidence: 99%

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Ren

Fan

Alkildani³

et al. 2022

IJMS

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“…Thirty-nine full-text research articles [ 19 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ] were finalized for analyses. These articles were divided into two broad categories, viz., NCPs and Natural products, while only one study assessed amelogenin peptide for dentine remineralization.…”

Section: Resultsmentioning

confidence: 99%

“…The preparation of artificial carious lesions by the use of demineralizing solution either alone [ 37 , 48 ] or with remineralizing solution (pH-cycling procedure) [ 27 , 32 , 34 , 36 , 49 , 59 ] was reported. Some studies used 20–37% phosphoric acid to induce demineralization [ 28 , 29 , 30 , 38 , 40 , 43 , 47 , 51 , 58 , 61 , 63 ], followed by phosphorylation using STMP [ 58 ] or covered with a Portland-cement-based lining composite [ 61 ]. Some studies used 14–17% EDTA to induce demineralization [ 33 , 35 , 39 , 42 , 44 , 45 , 46 , 50 , 60 ], while other studies used acetate buffer solution [ 19 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis

et al. 2023

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The objective of this article was to systematically provide an up-to-date review on the different methods of remineralizing human dentine using different biomimetic agents. The authors performed a systematic search within PubMed, Scopus, and Web of Science in addition to the grey literature in Google Scholar® using MeSH terms. The PICO question was P: human teeth dentinal sections; I: application of biomimetic remineralizing agents; C: other non-biomimetic approaches; O: extent of remineralization and physical properties of remineralized dentine. The initially identified studies were screened for titles and abstracts. Non-English articles, reviews, animal studies, studies involving the resin–dentine interface, and other irrelevant articles were then excluded. The other remaining full-text articles were retrieved. Bibliographies of the remaining articles were searched for relevant studies that could be included. A total of 4741 articles were found, and finally, 39 full-text articles were incorporated in the current systematic review. From these, twenty-six research studies used non-collagenous protein (NCP) analogs to biomineralize dentine, six studies used bioactive materials derived from natural sources, six studies used zinc hydroxyapatite, and one study used amelogenin peptide to induce hydroxyapatite formation on the surface of demineralized dentine. Additive effects of triclosan and epigenin were assessed when combined with commonly available NCPs. Overall, a moderate risk of bias was observed and, hence, the findings of the included studies could be acceptable. A meta-analysis of some similar studies was performed to assess the depth of remineralization and elastic modulus. Despite having high heterogeneity (I2 > 90), all the studies showed a significant improvement in biomimetic remineralization efficacy as compared to the control. All the included studies carried out a functional remineralization assessment and found a 90–98% efficacy in the extent of remineralization while the elastic modulus reached 88.78 ± 8.35 GPa, which is close to natural dentine. It is pertinent to note the limitations of these studies that have been carried out in vitro under controlled settings, which lack the effects of a natural oral environment. To conclude, the authors suggest that the biomimetic remineralization of dentine using NCP analogs, bioactive materials, and natural products carries significant potential in treating dentinal lesions; however, more long-term studies are needed to assess their clinical applications in vivo.

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“…48 The non-collagenous organic components of dentin include non-collagenous proteins such as dentin sialoproteins, phosphoproteins and proteoglycans, which are hypothesized to modulate the mineralization of collagen scaffolds to form dentinal tissue. 49,50 Proteoglycans consist of a small protein core, which is covalently linked to the side chains of glycosaminoglycans. 51 In particular, it has been postulated that glycosaminoglycans act as bridges between adjacent collagen fibrils, maintaining the mechanical and structural integrity of connective tissues.…”

Section: Discussionmentioning

confidence: 99%

Infrared Spectroscopy to Analyze Sexual Dimorphism of Hard Dental Tissue Maturation at Eruption in Patients with Connective Tissue Dysplasia

et al. 2023

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The aim of the study was to study biochemical changes in the hard tissues of the lower "wisdom" teeth, which are at the stage of eruption, with connective tissue dysplasia, depending on sex. The study involved 38 patients aged 17-25 years, who had the extraction of the lower third molars on the left and right for medical reasons. 21 participants in the experiment (16 females, 5 males) were diagnosed with connective tissue dysplasia; the remaining 17 were healthy and made up the control group (11 females, 6 males). Samples of enamel, dentin, and enamel-dentine junction were dried to constant weight and examined in tablets pressed in a mixture with potassium bromide on an FT-801 IR-Fourier spectrometer (SIMEX) in the range of 500-4000 cm-1. In the IR spectra of enamel, enamel-dentine junction and dentin, the ratio of the absorption bands of amide I and II changed significantly and the intensity of the absorption band of phosphate ions decreased from enamel to dentin. Differences between groups with and without connective tissue dysplasia increased in the following series: dentin, enamel-dentin junction, enamel. With connective tissue dysplasia, a change in the ratio of the intensities of the absorption bands of amide I and phosphate ions was observed. Normally, the content of organic substances in the enamel of the teeth in the males group is lower than in the females group. Against the background of connective tissue dysplasia, the content of organic substances in the enamel in women decreased while in men it increased, which confirmed the presence of sexual dimorphism during the maturation of hard dental tissues at the eruption stage. The study confirms the opinion of many researchers about the significant role of collagen proteins, which, together with non-collagen proteins, are involved in the development and maturation of dental hard tissues, which are characterized by pronounced heterogeneity and sexual dimorphism in the group with connective tissue dysplasia.

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Modification of collagen with proanthocyanidins by mimicking the bridging role of glycosaminoglycans for dentine remineralization

Cited by 9 publications

References 56 publications

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis

Infrared Spectroscopy to Analyze Sexual Dimorphism of Hard Dental Tissue Maturation at Eruption in Patients with Connective Tissue Dysplasia

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