Modification of collagen with a natural derived cross-linker, alginate dialdehyde

Hu, Yang; Liu, Lan; Gu, Zhipeng; Dan, Weihua; Dan, Nianhua; Yu, Xixun

doi:10.1016/j.carbpol.2013.11.050

Cited by 147 publications

(87 citation statements)

References 31 publications

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“…It is widely used in the pharmaceutical and medical fields [23]. Although collagen has many advantages [24], the reconstructed collagen-based scaffolds usually suffer from poor physicochemical properties which limit their application [25].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Shi

Yuan

Khan

et al. 2015

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Shi

Yuan

Khan

et al. 2015

Materials Science and Engineering: C

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“…Likewise, crosslinking is also a key factor to obtain satisfied strength for other edible collagen based films and stuff, receiving a great deal of attention in food industry recently [5][6][7][8]. Some synthetic crosslinkers such as formaldehyde, glutaraldehyde, and carbodiimide (EDC) have been maturely developed for the collagen cross-linking [9]. It is well-known that these crosslinkers have dual characteristics: excellent efficiency and potential toxicity.…”

Section: Introductionmentioning

confidence: 99%

Physical crosslinkings of edible collagen casing

Wang

Zhang

et al. 2015

International Journal of Biological Macromolecules

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“…31,32 Typically, an I 1235/1450 cm −1 close to unity indicates an intact triple-helical structure, whereas an I 1235/1450 cm −1 significantly lower than unity suggests that the triple helicity has been completely destroyed (e.g., the typical I 1235/1450 cm −1 for denatured collagen was reported to be as low as 0.60). 31,32 Typically, an I 1235/1450 cm −1 close to unity indicates an intact triple-helical structure, whereas an I 1235/1450 cm −1 significantly lower than unity suggests that the triple helicity has been completely destroyed (e.g., the typical I 1235/1450 cm −1 for denatured collagen was reported to be as low as 0.60).…”

mentioning

confidence: 99%

Poly(N-acryloyl ciprofloxacin-co-acrylic acid) grafted magnetite nanoparticles for microbial decontamination of collagen solution: have we conquered the problem of antimicrobial residues?

et al. 2015

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Widespread concern over antimicrobial toxicity and resistance development necessitates the thorough recovery of antimicrobial compounds from decontaminated collagen. Herein, ciprofloxacin molecules were acryloylated by reaction of the secondary amine in 7-piperazinyl substituent with acryloyl chloride, and then covalently immobilized, for the first time, on the vinyl-functionalized Fe 3 O 4 nanoparticle surface via graft copolymerization with acrylic acid, in an effort to design a magnetically-recoverable nanocomposite potentially applicable for microbial decontamination of collagen solution. Unlike previous magnetite-supported antimicrobials invariably involving the release of antimicrobially-active component, these immobilized ciprofloxacin moieties proved non-leachable, in whole or in part, from the magnetite core, exerting antimicrobial activity as free ciprofloxacin, and thus could be thoroughly recovered from decontaminated collagen solution under magnetic fields. Also, it was found that the unique triple-helical conformation and, hence, bioactive properties of tropocollagens remained intact after decontamination using such recoverable antimicrobials. This proof-of-principle study aims to shed light on a long-standing dilemma in the collagen community: how to decontaminate collagen using antimicrobial compounds without being subject to antimicrobial residues? † Electronic supplementary information (ESI) available: Fourier transform infrared (FTIR), 1 H and 13 C Nuclear Magnetic Resonance (NMR) spectroscopy, and Energy Dispersive X-ray (EDX) spectra. See

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Modification of collagen with a natural derived cross-linker, alginate dialdehyde

Cited by 147 publications

References 31 publications

Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation

Physical crosslinkings of edible collagen casing

Poly(N-acryloyl ciprofloxacin-co-acrylic acid) grafted magnetite nanoparticles for microbial decontamination of collagen solution: have we conquered the problem of antimicrobial residues?

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