Modification of Chromosomal Aberration Yield by Postirradiation Treatment

Wolff, Sheldon M.; Luippold, H. E.

doi:10.1093/genetics/43.3.493

Cited by 33 publications

(1 citation statement)

References 5 publications

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“…He observed a decrease in aberration yield that resulted from a decrease in the D2 component of the equation. From these observations it has been argued that repair of the primary lesion occurs over an average period of time commonly referred to as the "rejoining time" (see WOLFF and LUIPPOLD 1958). Thus, when a total dose is protracted or split into two portions over a time-span greater than the rejoining time, the lesions produced by the first portion of the dose are repaired before those produced by the subsequent portion of the dose are available for interaction.…”

mentioning

confidence: 99%

X-Ray-Induced Chromosome Aberrations in Mouse Dictyate Oocytes. Ii. Fractionation and Dose Rate Effects

Brewen

Payne

Adler³

1977

Genetics

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Split-dose experiments were done on maturing dictyate oocytes to determine if the magnitude of the first dose influenced the "rejoining time" of radiation-induced chromosomal lesions. A total dose of 400r was split into various combinations with varying fractionation intervals. The data derived from analyzing interchanges indicate that there is no difference in the rejoining time whether the first dose was 100, 200, or 300r. It thus appears that the radiation dose in the ranges studied does not significantly alter the rate of repair of the chromosomal lesions. This conclusion is contrary to that which has been propounded to explain the nonlinear dose curves obtained for specific locus mutations. Chronic 60Co Υ-ray exposures were given to female mice over an 8-day period. The exposures were delivered during the period of peak sensitivity, i.e., 8-16 days prior to ovulation. The doses given were 117, 240, 348, and 483r. The aberration yields observed were dramatically lower than for comparable doses of acute X rays even when the RBE of Υ rays compared with X rays is taken into account. The large drop in yields at the low dose rates is interpreted as resulting from a large two-track component in the acute curve, and as being independent of effects on repair systems.

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confidence: 99%

X-Ray-Induced Chromosome Aberrations in Mouse Dictyate Oocytes. Ii. Fractionation and Dose Rate Effects

Brewen

Payne

Adler³

1977

Genetics

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Studies on the Effect of Carbon Dioxide on X Ray–induced Chromosome Aberrations in Tradescantia. Ii. Relation to Dose Rate and Environment During Irradiation

Lachance

1961

American J of Botany

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LACHANCE, LEO E. (Biology Dept., Brookhaven Nat. Lab., Upton, L. L, N. Y.) Studies on the effect of carbon dioxide on X ray-induced chromosome aberrations in Tradescantia. II. Relation to dose rate and environment during irradiation. Amer. lour. Bot. 48(6) : 489-492. 1961.-The effect of carbon dioxide on radiation-induced chromosome aberrations has been investigated to determine the relation of this agent to dose rate and the efficacy of a pretreatment followed by X-irradiation in nitrogen or in vacuo. Carbon dioxide and air, present during the radiation treatment, significantly increase the frequency of chromosome aberrations induced by 300 r of X rays through a 46-fold difference in dose rate. Pretreatment with CO 2 and air also increases the aberration frequency if the radiation occurs in air. Pretreatment is completely ineffective when the inflorescences are irradiated in vacuo or in nitrogen. Thus it appears that CO 2 acts synergistically with oxygen in increasing the frequency of chromosome aberrations induced by X rays.

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Repair of X-ray damage I: Repair of chromosome breaks

Auerbach

1976

Mutation Research

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Modification of Chromosomal Aberration Yield by Postirradiation Treatment

Cited by 33 publications

References 5 publications

X-Ray-Induced Chromosome Aberrations in Mouse Dictyate Oocytes. Ii. Fractionation and Dose Rate Effects

X-Ray-Induced Chromosome Aberrations in Mouse Dictyate Oocytes. Ii. Fractionation and Dose Rate Effects

Studies on the Effect of Carbon Dioxide on X Ray–induced Chromosome Aberrations in Tradescantia. Ii. Relation to Dose Rate and Environment During Irradiation

Repair of X-ray damage I: Repair of chromosome breaks

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