Modification of chitosan by using samarium for potential use in drug delivery system

Kusrini, Eny; Arbianti, Rita; Sofyan, Nofrijon; Abdullah, Mohd Aidil Adhha; Andriani, Fika

doi:10.1016/j.saa.2013.09.132

Cited by 18 publications

(20 citation statements)

References 16 publications

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“…The narrow distribution indicates that the chitosan nanoparticles produced would be suitable as drug carriers for delivery. Drug carriers characterized by homogeneous and small particle sizes and similar morphology are more efficient for drug loading and delivery (Yang et al, 2010;Kusrini et al, 2014).…”

Section: Particle Size Distribution Studiesmentioning

confidence: 99%

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Kusrini¹,

Ng²,

Harahap³

et al. 2015

IJTech

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In this research, we studied the preparation of nanochitosan from the addition of potassium persulfate as an initiator for monomer polymerization and monocarboxylic acid-namely acetic acid, lactic acid, and formic acid-to a chitosan solution. To obtain the dried form of chitosan nanoparticles, we investigated the effects of oven and spray drying systems toward the physicochemical properties and morphology of chitosan nanoparticles. Successfully prepared chitosan nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Microscopy/Energy Dispersive X-ray Analysis (FESEM-EDX), and a particle size analyzer (PSA). The structures of nanochitosan prepared in different acids were quite similar based on the FTIR spectra. By increasing the concentrations of potassium persulfate, the yields of chitosan nanoparticles also increased. The concentration of potassium persulfate had a significant influence on the production of chitosan nanoparticles. The lowest concentration of potassium persulfate (0.6 mmol) did not produce an observable formation of chitosan nanoparticles. By using formic acid and potassium persulfate in various concentrations from 1.2-3.0 mmol, chitosan nanoparticles were obtained. A particle size distribution of chitosan nanoparticles was produced from a formic acid solution having a smaller size compared to others. The acidity effect of monocarboxylic acids in the formation of chitosan nanoparticles was better compared to the addition of other acids. Furthermore, synthesized chitosan nanoparticles (50-110 nm) produced from formic acid solutions have potential applications for drug carrier purposes.

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Section: Particle Size Distribution Studiesmentioning

confidence: 99%

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Kusrini¹,

Ng²,

Harahap³

et al. 2015

IJTech

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“…Fluorescence intensity of microsphere formulations increased with the cumulative 030011-3 amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm 3+ ion could be used as indicator in DDS. The Sm 3+ ions was bonded with the hydroxyl groups of chitosan that resulted Sm 3+ ions fluorescence intensity increases with the ranitidine cumulative amount released from the Chit/Sm/Fe3O4/Rn [5]. The existence of samarium in the chitosan matrix has function as a tracer or marker of drug release.…”

Section: Figure 1 (A) Xrd Characterization Results Of Fe3o4 (B) Vsm mentioning

confidence: 99%

“…Preparation of drug adsorption and release system were prepared in accordance with literature [5]. In drug loading, 50 mg matrices was dissolved in 25 ml of distilled water and then allowed to stand for 24 h. After 24 h, retentate and the filtrate was measured its absorbance by using UV-Vis spectrophotometry.…”

Section: Drug Loading and Drug Release Studiesmentioning

confidence: 99%

Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system

Kusrini

Prassanti

Nurjaya

et al. 2017

AIP Conference Proceedings

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Abstract. The microsphere formulations of Chit/TPP/Sm/Fe3O4/Rn were prepared by an ionic gelation technique, where Chit = chitosan, TPP = tripolyphosphate, Sm = samarium and Rn = ranitidine. Optimum of microsphere formulation exhibit magnetic and fluorescent properties with adsorption efficiency of ~92% was obtained for Chit/TPP/Sm/Fe3O4/Rn with ratio 400:500:50:1:20. Fluorescence intensity of microsphere formulations increased with the cumulative amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm 3+ ion could be used as indicator in DDS. With the demonstration of sustained release from microsphere formulation, it allows to investigate the applications to other drugs.

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“…Luo et al has discussed about Nano/micro particle, hydrogel beads, layer by layer film based chitosan DDS system [9]. Kusrini et al has modified chitosan using samarium to improve drug release [10]. Bernkop-Schnrch et al has discussed about the cationic nature of chitosan for controlled drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Investigation of electrical stimulus on chitosan film based DDS

Sahadat¹,

Hoban

Morshed³

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Controlled drug release is crucial for targeted implant smart drug delivery system (DDS). In this work a chitosan film loaded with green food coloring is fabricated to demonstrate the concepts of drug release using electrical stimulus. A simulation model is also developed to explain the physical phenomena of this drug release using finite element method (FEM). It is found that drug delivery is increased with applied electric field to the electrodes on chitosan film. The AC electrokinetic force generated from electrical excitation is a factor influencing this phenomenon. Several controlled and stimuli experiments are conducted with different electric fields and frequencies. The spectral absorbance of treated solution after the experiment is measured using a spectrophotometer to quantify the dye release. It is verified statistically with 99% level of significance that the amount of dye release has increased with applied electric field. Thus this work has shown that application of electric field can be a potential candidate for controlled DDS using chitosan film.

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Modification of chitosan by using samarium for potential use in drug delivery system

Cited by 18 publications

References 16 publications

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system

Investigation of electrical stimulus on chitosan film based DDS

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