Modification of cellulose by graft polymerization for use in drug delivery systems

Moghaddam, Peyman Najafi; Avval, Mahsa Ensafi; Fareghi, Amir Reza

doi:10.1007/s00396-013-3042-6

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…During grinding, BAB was added dropwise to the mortar while the mortar was kept in ice bath to control the heat of the reaction. The advantages of this method, compared to solvent dispersion method, are solvent nonuse and it needs a shorter reaction time . In the next step, urea was used as crosslinking agent to synthesize the CBA‐cell hydrogel.…”

Section: Resultsmentioning

confidence: 99%

“…The advantages of this method, compared to solvent dispersion method, are solvent nonuse and it needs a shorter reaction time. 31,[38][39][40] In the next step, urea was used as crosslinking agent to synthesize the CBA-cell hydrogel. This reaction was carried out in DMF in the presence of TEA, to neutralize generated HBr (Scheme 2).…”

Section: Synthesis and Preparation Of Ba-cell And Hydrogel Networkmentioning

confidence: 99%

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Synthesis of a cellulose‐based hydrogel network: Characterization and study of urea fertilizer slow release

Mohammadi-Khoo

Moghadam

Fareghi

et al. 2015

J of Applied Polymer Sci

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In the present study, we synthesized a low‐cost biodegradable hydrogel based on cellulose in order to perform controlled release of fertilizer. For this purpose, the cellulose was modified and crosslinked with urea. Then the prepared hydrogel underwent loading with the fertilizer in order to study the controlled release. Characterization of the samples was carried out by Fourier Transform Infrared (FT‐IR) spectroscopy, elemental analysis, thermal gravimetric analysis (TGA), and scanning electron microscopy (SEM). The hydrogel showed a good swelling behavior in distilled water, tap water, and 0.9% NaCl solution. Besides, water holding and water retention behavior of the hydrogel was investigated. Finally, the release of fertilizer from the loaded hydrogel was studied and showed excellent controlled release. According to the results, this hydrogel can be employed as a suitable moisture‐holding additive in the soil for agricultural purposes. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42935.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Preparation Of Ba-cell And Hydrogel Networkmentioning

confidence: 99%

Synthesis of a cellulose‐based hydrogel network: Characterization and study of urea fertilizer slow release

Mohammadi-Khoo

Moghadam

Fareghi

et al. 2015

J of Applied Polymer Sci

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“…Cellulose has a linear b-(1-4) linked glucan structure, which enables strong cooperative intraand intermolecular hydrogen bond patterns and also stiffens the chain (Guo et al 2013a;Klemm et al 2005;Moghaddam et al 2014). As a result, cellulose cannot be dissolved in normal organic solvents, while most amphiphilic modifications of cellulose need to introduce liposoluble side chains.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and micellar behaviors of hydroxyethyl cellulose-graft-poly(lactide/ε-caprolactone/p-dioxanone)

Guo

Zhong

et al. 2015

Cellulose

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In response to the shortage of petroleum resources and the growing need for sustainable development, cellulose-based amphiphilic copolymers have emerged as a new generation of valueadded functional nanostructures from biomass resources. In this article, 17 amphiphilic hydroxyethyl cellulose-based graft copolymers with different side chains, including poly(lactide), poly(e-caprolactone) and poly(p-dioxanone), were synthesized via homogeneous ring opening polymerization in ionic liquid 1-butyl-3-methylimidazolium chloride and characterized by FT-IR, 1 H NMR, thermogravimetric analysis and gel permeation chromatography. The resultant copolymers can self-assemble into micelles with a low critical micelle concentration that varies in the range of 0.03-0.24 mg/ml. TEM observations revealed the obtained micelles had a spherical and well-distributed morphology, and DLS analysis showed the nanoscaled sizes were between 40 and 150 nm. These HEC-based micelles can be used as nano-sized vesicles and have great latent forces in drug delivery systems.

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“…To overcome these problems, the researchers modified cellulose chemically. Chemical modification of cellulose can change its chemical and morphological structures for different purposes .…”

Section: Introductionmentioning

confidence: 99%

Folic acid linked amino‐cellulose for in vitro evaluation of doxorubicin delivery: Synthesis and characterization

Movagharnezhad

Moghadam

2015

Starch Stärke

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In this study, cellulose, a biodegradable polymer, was successfully aminated. For this purpose the cellulose was converted to a bromoacetylated derivative by reaction with bromoacetyl bromide. The resulting bromide derivative was then substituted with azido groups by reaction with sodium azide. Then the azido group was reduced to amines via the formation of the triphenylphosphinimine intermediate followed by hydrolysis using aqueous hydrazine. This sequence produced amino-cellulose. To gain a tumor-targeting doxorubicin (DOX) delivery system, we conjugated an active tumor-targeting ligand, folic acid, to the end of the resulting copolymer (FA-Amino-Cell). The structure of this copolymer was confirmed by FT-IR, UV-Vis, TGA, SEM, and 1 H NMR spectroscopy. The SEM images showed that the hydrodynamic dimension of the resulted product is about 40 nm. Moreover, the Release profiles of DOX from the FA-Amino-Cell and its loading capacity were determined by UV-Vis absorption measurement at l max 483 nm. The results showed that the DOX loaded copolymer had good control on the release period of DOX. So, it seems that the FA-Amino-Cell is a potential candidate for the targeted delivery of DOX for cancer treatment.

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Modification of cellulose by graft polymerization for use in drug delivery systems

Cited by 22 publications

References 26 publications

Synthesis of a cellulose‐based hydrogel network: Characterization and study of urea fertilizer slow release

Synthesis of a cellulose‐based hydrogel network: Characterization and study of urea fertilizer slow release

Synthesis, characterization, and micellar behaviors of hydroxyethyl cellulose-graft-poly(lactide/ε-caprolactone/p-dioxanone)

Folic acid linked amino‐cellulose for in vitro evaluation of doxorubicin delivery: Synthesis and characterization

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