Modification of catalytic properties of amine oxidases

Amino oxidase activity of hepatopancreas preparations from the octopus Bathypolypus arcticus

“…Appar ently, one should agree with the opinion of Professor Gorkin [1] that the enzymes that attack the aliphatic compounds with a terminal amino group, such as semicarbazide sensitive and semicarbazide resistant amine oxidases, constitute a "whole family of homol ogous enzymes," which have similar properties and have common substrates and inhibitors. It is assumed that there is a certain relationship between the two main classes of amine oxidases: after the treatment with certain oxidants, MAO underwent transforma tion and acquired new catalytic properties resembling those of DAO [14]; after the treatment with certain reducers, DAO preparations acquired qualitatively new properties similar to the catalytic properties of MAO [15]. The study of the substrate-inhibitor spec ificity of the mitochondrial MAO of the hepatopan creas of octopus B. arcticus showed the "kinetic" homogeneity of the enzyme.…”

Conformational Design and Characterisation of a Truncated Diamine Oxidase from Arthrobacter globiformis

“…Diamine oxidase was first reported in 1929 and seemed to be responsible for physiological conditions when the enzyme activity was low, especially, when there is a critical decrease of the enzyme in the metabolism of histamine [ 8 ]. Scientists are captivated by its unique characteristics in the body and brain under various conditions, especially in the evolution of a new drug [ 9 ]. Its core function is to degrade the histamine formed in tissues.…”