Modification of Carbon Tetrachloride-Induced Hepatotoxicity by Clofibric Acid in Rats

Yamakawa, Yoshihiro; Doi, Takaaki; Kubota, Katsuaki; Okayachi, Hiroshi; Kudo, Naomi; Kawashima, Yasunaru

doi:10.1248/jhs.46.132

JOURNAL OF HEALTH SCIENCE

2000

DOI: 10.1248/jhs.46.132

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Modification of Carbon Tetrachloride-Induced Hepatotoxicity by Clofibric Acid in Rats

Yoshihiro Yamakawa¹,

Takaaki Doi²,

Katsuaki Kubota³

et al.

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Cited by 2 publications

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FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

Kong

Wang

et al. 2014

Inflammation

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FTY720 is a novel immunosuppressant that modulates sphingosine 1-phosphate (S1P) receptors for the treatment of several diseases. Several hallmarks of liver fibrosis are influenced by S1P, and the interference of S1P signaling by treatment with FTY720 results in beneficial effects in various animal models of fibrosis. However, whether these treatment strategies suppress liver fibrosis progression is incompletely understood. Here, we investigated the effects and mechanisms by which FTY720 improves liver fibrosis in the carbon tetrachloride (CCl4)-induced mouse model. FTY720 treatment significantly attenuated the expression of fibrotic markers in the injured liver of both wild-type and SCID-beige mice. The migration of bone marrow-derived mesenchymal stem cells (BMSCs) to circulation, and subsequently the injured liver, was suppressed by FTY720. Furthermore, in vitro, phosphorylated-FTY720 blocked the migration of BMSCs mediated by S1P. Thus, FTY720 is an effective therapy for liver fibrosis via the suppression of BMSC migration in the CCl4-induced mouse model.

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FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

Kong

Wang

et al. 2014

Inflammation

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show abstract

A single pretreatment with clofibric acid attenuates carbon tetrachloride-induced necrosis, but not steatosis, in rat liver

Yamakawa

Doi

Naitou

et al. 2020

Food and Chemical Toxicology

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Modification of Carbon Tetrachloride-Induced Hepatotoxicity by Clofibric Acid in Rats

Cited by 2 publications

References 0 publications

FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

A single pretreatment with clofibric acid attenuates carbon tetrachloride-induced necrosis, but not steatosis, in rat liver

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