Modification of a Polyethersulfone Matrix by Grafting Functional Groups and the Research of Biomedical Performance

Abstract

A new method for the functional modification of polyethersulfone (PES) is described in this paper in which PES was sulfonated by chlorosulfonic acid firstly and then chlorinated by phosphorus pentachloride. Thereby, chlorosulfonic groups (-SO2Cl) were introduced in PES successfully, and the degree of the chlorosulfonation was about 15%. Since the chlorosulfonic group is reactive enough towards the amino group (-NH2), the conformation of chlorosulfonic-based covalent bonding functional route could further extend the PES application area with versatile functionality. In this article, hydroxyl (-OH), carboxyl (-COOH), amino (-NH2) and methyl (-CH3) groups were grafted onto a PES matrix through the reaction of chlorosulfonic groups and the amino groups. The functional groups have effects on protein adsorption and cell behavior. The membrane modified with an amino group was in favor of cell adhesion and proliferation, and the membrane modified with hydroxyl and methyl did not so well as the membrane modified with an amino group, which will give guidance for biomaterial modification.

Fabrication and Assessment of ZnO Modified Polyethersulfone Membranes for Fouling Reduction of Bovine Serum Albumin

“…Several approaches have been explored to alleviate the fouling problem of PES membranes. These are grafting of the membranes with surface functionalities to enhance hydrophilic surface characteristics [9][10][11], impacting substances with catalytic properties to degrade foulants on the membrane surface [12][13][14], and impacting substances with antibacterial effects to limit the adhesion of biomolecules/bacteria that lead to biofouling [4,15,16]. Incorporating nanoparticles to increase surface hydrophilicity of the membranes in water treatment has received more attention, recently.…”

Poly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells

“…Thus, MSCs emerge as an important player of cellular-based therapies and new approaches are required to increase the viability and functionality of MSCs. For post-polymer surface modifications, reactive co-monomers, typically containing epoxy groups are generally used for single step post polymerization techniques [12,17,18].…”

Novel Synthetic Approach to Tune the Surface Properties of Polymeric Films: Ionic Exchange Reaction between Sulfonated Polyarylethersulfones and Ionic Liquids

“…It is a completely amorphous polymer, characterized by excellent UV and thermal resistance (e.g. high glass transition temperature, T g , up to 230°C and low thermal expansion coefficient), optical properties (refractive index: n=1.63 at λ=589.3 nm), chemical stability [23], oxidation resistance [24], as well as by good mechanical properties [25] and easy processability [26]. SPESs can be prepared via two different synthetic routes; one is the synthesis of Polyarylethersulfone (PES) followed by post-sulfonation reaction with sulfonating agents, commonly defined as "heterogeneous synthesis" [27], the other uses pre-sulfonated monomers in the feed of the polymerization reaction and is defined "homogeneous synthesis" [28].…”