Modification by Methyltyrosine Methylester (H 44/68) of the Amphetamine‐Induced Toxicity and Brain Catecholamine Changes in Developing Mice

Alhava, Eeva

doi:10.1111/j.1600-0773.1973.tb01456.x

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in a previous study (ALHAVA 1973), the 13-15-day-old mice seemed to be at a particular stage of development as regards the brain DA levels. The DA pool of this age group was particularly resistant to the inhibition of tyrosine hydroxylase (ALHAVA 1973), and after L-DOPA a marked overshooting of the DA level could be seen. The decarboxylation of L-DOPA appears to be effective in the developing organism.…”

Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 58%

“…The brain CA-changes in response to L-DOPA methylester differ between developing and adult mice as was also found after the administration of methyltyrosine methylester (ALHAVA 1973). As shown in a previous study (ALHAVA 1973), the 13-15-day-old mice seemed to be at a particular stage of development as regards the brain DA levels. The DA pool of this age group was particularly resistant to the inhibition of tyrosine hydroxylase (ALHAVA 1973), and after L-DOPA a marked overshooting of the DA level could be seen.…”

Section: Discussionsupporting

confidence: 58%

“…the mechanisms of amphetamine toxicity and CA-responses induced by the drug in adult and developing mice is a very complex process (ALHAVA 1972;ALHAVA & KLINGE 1972;ALHAVA 1973). The protective effect o f inhibition of the CA biosynthesis by methyltyrosine against amphetamine toxicity in adult mice was well documented by MENON & DANDIYA (1967), and this could also be reproduced in developing mice (ALHAVA 1973). Amphetamine enhanced the central CA reduction induced by methyltyrosine in adult and developing mice, which was assumed to reflect the accelerating effect of amphetamine on CA metabolism (ALHAVA 1973).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Modification by L‐DOPA Methylester (H 19/61) of Amphetamine‐Induced Brain Catecholamine Changes, Thermal Responses and Toxicity in Developing Mice

Alhava

1973

Acta Pharmacologica et Toxicologica

Self Cite

View full text Add to dashboard Cite

The effect of 150 mg/kg of L‐DOPA methylester on brain catecholamines was studied in adult and developing mice aged 3‐5 days and 13‐15 days. Noradrenaline was moderately increased in the developing brain but dopamine showed a manyfold increase. The increase of dopamine was less pronounced in adult brain. High doses of dl‐amphetamine (50‐160 mg/kg) injected to L‐DOPA pretreated mice further increased the dopamine levels in the developing brain. The adult brain catecholamines were remarkably depleted, provided the observation period was 4 hours after amphetamine. Amphetamine lowered the body temperature in mice aged 13‐15 days; the fall was dose‐dependent and potentiated by pretreatment with L‐DOPA. In adult mice amphetamine caused hyperthermia which was not modified by L‐DOPA. L‐DOPA did not change the mortality rates induced by amphetamine in developing mice, but infant mice pretreated with L‐DOPA showed a lower brain amphetamine concentration after death than the mice given amphetamine only. In adult mice GDOPA enhanced amphetamine toxicity. Special attention is paid to the importance of different turnover rates of catecholamines during development as well as to the complex action of amphetamine on enzymes regulating catecholamine turnover. It is assumed that the hypothermia of developing mice after amphetamine might result from the primary effect of amphetamine on dopaminergic mechanisms.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 58%

Section: Discussionsupporting

confidence: 58%

mentioning

confidence: 99%

See 2 more Smart Citations

Modification by L‐DOPA Methylester (H 19/61) of Amphetamine‐Induced Brain Catecholamine Changes, Thermal Responses and Toxicity in Developing Mice

Alhava

1973

Acta Pharmacologica et Toxicologica

Self Cite

View full text Add to dashboard Cite

show abstract

General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

View full text Add to dashboard Cite

Amphetamine and related central stimulant drugs are derivatives of ß-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general ßphenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itselfhas central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the ex-methyl group, much less affinity for MAO and therefore has a longer half-Iife.Most amphetamines have cardiovascular, psychomotor stimulant, hyperthermic, and anorexigenic actions. All of the structural features of amphetamine are important far its spectrum of pharmacologic activity. Any alteration may enhance, diminish, or attenuate one or several components in the actions of the parent drug. (1) Substitution of the phenyl ring, (2) alteration of the length of the side chain, (3) substitution on the primary nitrogen group, (4) substitution of the ex-and ß-carbon atoms, and (5) their absolute configuration have been studied and will be briefly discussed here. For a more thorough review on the subject the reader is referred to the papers by BIEL (1970), vANRossuM and SIMONS (1969) and VREE (1973. The effect of ring and side-chain substitution on distribution and elimination of the amphetamines has been discussed by BECKETT and BROOKES (1970). recently reviewed the biochemical pharmacology of the amphetamines. The metabolism and disposition of methylphenidate were reported by F ARAJ et al.

show abstract

The Pharmacological Profile of Some Psychomotor Stimulant Drugs Including Chemical, Neurophysiological, Biochemical, and Toxicological Aspects

Garattini¹,

Samanin²

1981

Psychotropic Agents

View full text Add to dashboard Cite

Modification by Methyltyrosine Methylester (H 44/68) of the Amphetamine‐Induced Toxicity and Brain Catecholamine Changes in Developing Mice

Cited by 3 publications

References 9 publications

Modification by L‐DOPA Methylester (H 19/61) of Amphetamine‐Induced Brain Catecholamine Changes, Thermal Responses and Toxicity in Developing Mice

Modification by L‐DOPA Methylester (H 19/61) of Amphetamine‐Induced Brain Catecholamine Changes, Thermal Responses and Toxicity in Developing Mice

General Pharmacology of Amphetamine-Like Drugs

The Pharmacological Profile of Some Psychomotor Stimulant Drugs Including Chemical, Neurophysiological, Biochemical, and Toxicological Aspects

Contact Info

Product

Resources

About