Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history

Wang, Shuyuan; Yuan, Zhen; Wang, Yuqi; Zhao, Xuanzhu; Gao, Weifeng; Li, Hongzhou; Zhao, Yuanshun; Zhang, Zili; Liang, Shuiqing; Liu, Zhaoce; Zhang, Qinghuai; Ma, Hong; Cui, Wei; Zhang, Chunze

doi:10.1186/s12885-022-10141-1

Cited by 5 publications

(3 citation statements)

References 54 publications

(78 reference statements)

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“…However, the social stigma associated with bowel cancer affects the accuracy of reporting a family history of CRC [5][6][7][8][9][10][11], as also reported in southern Taiwan [12]. However, many studies have shown that modifiable lifestyle factors including smoking, alcohol consumption, physical activity, and body mass index contribute more to CRC than family history [13,14].…”

Section: Discussionmentioning

confidence: 99%

Effects of Fecal Occult Blood Immunoassay Screening for Colorectal Cancer—Experience from a Hospital in Central Taiwan

Yang

Chiang

et al. 2023

Medicina

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Background and Objectives: In 2004, the Health Administration of Taiwan began to promote a hospital-based cancer screening quality improvement program, under the principle that “prevention is better than therapy”. The aim of this study was to evaluate the effectiveness of colorectal cancer (CRC) screening in patients who received a fecal immunochemical test (FIT) at a hospital in central Taiwan. Materials and Methods: This was a retrospective study. Results: Fecal occult blood immunoassays for CRC screening were conducted in 58,891 participants, of whom 6533 were positive (positive detection rate 11.10%). The positive patients then underwent colonoscopy, and the detection rates of polyps and CRC accounted for 53.6% and 2.4% of all colonoscopy-confirmed diagnoses (3607), respectively. We further enrolled data from patients diagnosed with CRC at our hospital from 2010 to 2018. The patients with CRC were divided into two groups according to whether or not they had received fecal occult blood screening. Among the 88 patients with CRC by screening, 54 had detailed medical records including cancer stage. Of these 54 patients, 1 (1.8%) had pre-stage, 11 (20.4%) had stage I, 24 (44.4%) had stage II, 10 (18.5%) had stage III, and 8 (14.8%) had stage IV CRC. The early cancer detection rates of the screening and non-screening groups were 66.7% and 52.7%, respectively, and the difference was significant (p = 0.00130). Conclusions: In this study, screening with FIT significantly increased the early detection of CRC. The main advantage of FIT is the non-invasiveness and low cost. It is hoped that the further adoption of early screening can increase the detection rates of colorectal polyps or early cancer to improve survival, reduce the high cost of subsequent cancer treatment, and reduce the burden on the patient and healthcare system.

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Section: Discussionmentioning

confidence: 99%

Effects of Fecal Occult Blood Immunoassay Screening for Colorectal Cancer—Experience from a Hospital in Central Taiwan

Yang

Chiang

et al. 2023

Medicina

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“…In Sweden, CRC has also been reported as the third most common cancer; more than 7000 new cases were reported in the Swedish Colorectal Cancer Registry in 2021 (40). Lifestyle factors, including poor diet, smoking, alcohol consumption, a lack of physical activity, and an increasing prevalence of obesity, play a significant role in the development of CRC (41). Cancer survival is highly dependent on the stage at diagnosis.…”

Section: Colorectal Cancermentioning

confidence: 99%

Faecal Calprotectin Diagnostics : Focus on Primary Care and Suspected Sources of Error

Rendek

2023

Linköping University Medical Dissertations

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Patients with gastrointestinal symptoms often present a diagnostic challenge for general practitioners. Faecal calprotectin (FC) is commonly used as a marker of intestinal inflammation and is useful for differentiating between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), as well as for the follow-up of patients with IBD and monitoring treatment response. However, several other causes of increased FC levels have been acknowledged, including intake of non-steroidal antiinflammatory drugs or proton pump inhibitors and respiratory infections. Currently, there is insufficient knowledge about how these factors affect FC levels. It is crucial that physicians who use calprotectin as a diagnostic tool have the ability to conduct a sound evaluation of the test result to ensure accurate clinical decisions, and potentially avoid unnecessary referrals and invasive investigations.

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“…Badanie przeprowadzone w Malezji sugeruje, że przez zmianę stylu życia można było zapobiec około 18% przypadków stwierdzonych tam w 2013 roku [10]. W Chinach przeprowadzono badanie wskazujące, że 29% zaawansowanych nowotworów jelita grubego u mężczyzn i 13,8% u kobiet można powiązać z modyfikowalnymi czynnikami ryzyka [11]. Poniżej omówione są najbardziej znane z tych czynników.…”

Section: Modyfikowalne Czynniki Ryzykaunclassified

Risk factors of colorectal cancer – literature review

Urbańczyk,

Rutkowska,

Skorek

et al. 2023

J Educ Health Sport

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Introduction and purpose: Colorectal cancer is one of the most common cancers in the world. It is very important to expand knowledge about this disease because it affects millions of people. Better understanding of the disease will help develop better prevention and treatment strategies. The aim of our work is to classify, analyze and describe colorectal cancer risk factors. This article was written based on articles found in the PubMed database. State of knowledge: Colorectal cancer risk factors can be divided into two groups: modifiable and unmodifiable. Modifiable factors include: diet, low physical activity, smoking, alcohol, overweight and obesity. Unmodifiable factors include: age, sex, inflammatory bowel diseases, genetic factors, family history of colorectal cancer. Each of them increases the risk of developing the disease, the risk is the greater the more factors are present simultaneously. Modifiable factors seem to play a greater role in the development of the disease than unmodifable factors. Summary: Studies of colorectal cancer risk factors may help in the development of prevention. It can also facilitate the personalization of preventive examinations and treatment. By influencing modifiable factors, we can reduce the risk of developing the disease, because following the principles of a healthy lifestyle can minimize the risk associated with genetic factors for the development of colorectal cancer.

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Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history

Cited by 5 publications

References 54 publications

Effects of Fecal Occult Blood Immunoassay Screening for Colorectal Cancer—Experience from a Hospital in Central Taiwan

Effects of Fecal Occult Blood Immunoassay Screening for Colorectal Cancer—Experience from a Hospital in Central Taiwan

Faecal Calprotectin Diagnostics : Focus on Primary Care and Suspected Sources of Error

Risk factors of colorectal cancer – literature review

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