Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study

Povey, A.; Clyma, J.- A.; McNamee, Roseanne; Moore, H. D. M.; Baillie, Helen; Pacey, Allan; Cherry, Nicola

doi:10.1093/humrep/des183

Cited by 89 publications

(71 citation statements)

References 25 publications

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“…The results are in agreement with previous studies which suggested that lifestyle factors may affect semen quality [Jensen et al 2004a;Povey et al 2012;Sallmen et al 2006]. In the present study increased BMI was significantly associated with a decreased semen volume.…”

Section: Discussionsupporting

confidence: 94%

“…The lower risk of poorer semen quality among men who usually wear boxer shorts is consistent with some [Povey et al 2012;Tiemessen et al 1996] but not with all previous studies [Munkelwitz and Gilbert 1998]. …”

Section: Discussionsupporting

confidence: 81%

“…Several studies also examined the effect of smoking and alcohol drinking on sperm parameters, but their results are inconsistent. Some studies [Marinelli et al 2004;Povey et al 2012] but not all [Li et al 2011;Ramlau-Hansen et al 2007;Vine 1996] suggested that smoking and alcohol has a limited effect on semen quality. However, recent reviews of male subfertility highlight how aspects of adult male lifestyle may significantly increase their risk of subfertility [Li et al 2011;Sadeu et al 2010].…”

Section: Introductionmentioning

confidence: 99%

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Lifestyle and semen quality: role of modifiable risk factors

Jurewicz

Radwan²,

Sobala

et al. 2013

Systems Biology in Reproductive Medicine

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(2014) Lifestyle and semen quality: role of modifiable risk factors, Systems Biology in Reproductive Medicine, 60:1, 43-51, DOI: 10.3109/19396368.2013.840687 To link to this article: https://doi.org/10. 3109/19396368.2013 AbstractThe relationship between exposure to lifestyle factors and adverse effects on human reproductive health is debated in the scientific literature and these controversies have increased public and regulatory attention. The aim of the study was to examine the association between modifiable lifestyle factors and main semen parameters, sperm morphology, and sperm chromatin structure. The study population consisted of 344 men who were attending an infertility clinic for diagnostic purposes with normal semen concentration of 20-300 M/ml or with slight oligozoospermia (semen total concentration of 15-20 M/ml) [WHO 1999]. Participants were interviewed and provided semen samples. The interview included questions about demographics, socio-economic status, medical history, lifestyle factors (consumption of alcohol, tobacco, coffee intake, cell phone and sauna usage), and physical activity. The results of the study suggest that lifestyle factors may affect semen quality. A negative association was found between increased body mass index (

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Lifestyle and semen quality: role of modifiable risk factors

Jurewicz

Radwan²,

Sobala

et al. 2013

Systems Biology in Reproductive Medicine

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“…Obesity in men is associated with an increased incidence of oligozoospermia and asthenozoospermia in some (84)(85)(86)(87)(88)(89)(90), but not all (91)(92)(93)(94)(95)(96)(97), studies. Moreover, increased abdominal adiposity in men of subfertile couples has been associated with reduced sperm count, concentration, and motility (90).…”

Section: Obesity and Male Reproductionmentioning

confidence: 99%

Obesity and reproduction: a committee opinion

2015

Fertility and Sterility

171

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“…While it has been reported that obese men are three times more likely to exhibit a reduction in sperm quality compared with men of normal weight (Sharma et al, 2013;Shulka et al, 2014), the true effect of obesity upon semen quality is a source of much debate. Numerous studies have shown that there is no relationship between increased BMI and one or more of the following semen parameters: sperm concentration, count, morphology, motility and ejaculate volume (Jensen et al, 2004;Fejes et al, 2006;Aggerholm et al, 2008;Hammoud et al, 2008;Paul et al, 2008;Nicopoulou et al, 2009;Chavarro et al, 2010;MacDonald et al, 2010;Martini et al, 2010;Povey et al, 2012;Hajshafi ha et al, 2013;Eisenberg et al, 2014;Pacey et al, 2014). Conversely, other studies show that BMI is associated with one or more of the following: sperm concentration, count, motility or ejaculate volume (Jensen et al, 2004;Fejes et al, 2006;Hammoud et al, 2006;Kort et al, 2006;Hofny et al, 2010;Chavarro et al, 2010;Sermondade et al, 2013;Eisenberg et al, 2014;Hadjkacem et al, 2015).…”

Section: Effects Upon Traditional Who Semen Parametersmentioning

confidence: 99%

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

et al. 2015

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Worldwide obesity rates have nearly doubled since 1980 and currently over 10% of the population is obese. In 2008, over 1.4 billion adults aged 20 years and older had a body mass index or BMI above a healthy weight and of these, over 200 million men and nearly 300 million women were obese. While obesity can have many ramifications upon adult life, one growing area of concern is that of reproductive capacity. Obesity affects male infertility by influencing the hypothalamic-pituitary-gonadal axis, thus causing detrimental effects upon spermatogenesis and subsequent fertility. In particular, evidence indicates that excess adipose tissue can alter the relative ratio of testosterone and oestrogen. Additional effects involve the homeostatic disruption of insulin, sex-hormone-binding-globulin, leptin and inhibin B, leading to diminished testosterone production and impairment to spermatogenesis. Aberrant spermatogenesis arising from obesity is associated with downstream changes in key semen parameters, defective sperm capacitation and binding, and deleterious effects on sperm chromatin structure. More recent investigations into trans-generational epigenetic inheritance further suggest that molecular changes in sperm that arise from obesity-related impaired spermatogenesis, such as modified sperm RNA levels, DNA methylation, protamination and histone acetylation, can impact upon the development of offspring. Here, we summarise our current understanding of how obesity exerts influence over spermatogenesis and subsequent fertility status, and make recommendations for future investigative research.

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Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study

Cited by 89 publications

References 25 publications

Lifestyle and semen quality: role of modifiable risk factors

Lifestyle and semen quality: role of modifiable risk factors

Obesity and reproduction: a committee opinion

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

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