Modi-2, a vaccine stimulating CD4 mediated responses to homocitrullinated self-epitopes, as a therapy for solid cancers
Lindy Durrant,
Abdullah Al-Omari,
Katherine Cook
et al.
Abstract:Stresses within the tumour microenvironment can mediate post-translational modifications (PTM) of self-proteins. Homocitrullination is the conversion of lysine residues to homocitrulline which can generate neoepitopes and bypass self-tolerance. In this study a vaccine targeting homocitrullinated peptide antigens was assessed for its ability to stimulate anti-tumour immunity. Peptides that bind HLA are often hydrophobic which can lead to complications with large scale manufacture and solubility that must be con… Show more
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