Modes of therapeutic delivery in synthetic microbiology

Alexander, Laura M.; Pijkeren, Jan-Peter van

doi:10.1016/j.tim.2022.09.003

Cited by 6 publications

(2 citation statements)

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“…These nanostructures have opened up new horizons of fundamental research and practical applications, but their implementation will require to fill gaps in our knowledge on a number of issues, as well as solving the problem of the safety of probiotics and the vesicles produced by them (13). A significant gap is also the lack of systematic and in-depth information about the contribution of the commensal bacteria cells, as well as their vesicles, to the epigenetic and metabolic changes in host that occur at the level of individual cells, causing the modulation of immunosensing and the development of local or systemic immunotolerance (14). Considering that MAMPs (Microbe-associated molecular patterns) there are in both symbiotic and pathogenic microbes, the machinery of differential recognition of commensals and pathogens is not clear.…”

Section: Data Acquisitionmentioning

confidence: 99%

Human and animal intestinal commensals and probiotics vs modern challenges of biosafety: problems and prospects

2023

ARI

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The appearance of an array of data on the study of the intestinal microbiota in Metazoa has significantly expanded our understanding of the role of commensals in the control of a wide range of physiological functions in higher organisms in norm and pathology. In the intestine, where the microbial load significantly exceeds the number of microorganisms of other ecosystems, the components of the intestinal microbiota are a constant source of stimuli that induce activation of the host immune systemThe introduction into practice of biomedical research of innovative high-resolution methods, including multi-omix technologies, has brought data that change our understanding of intestinal commensals, including probiotics with GRAS status, widely used in medicine, agriculture and biotechnology. The ability of these bacteria to induce negative processes in the host body that are beneficial for bacterial proliferation and expansion revealed a clear lack of our knowledge about the logic of their life and the mechanisms of interaction with eukaryotic cells. This determines the urgent need for comprehensive research of probiotics and the development of standardization of their safety assessment. Apriori's confidence in the exceptional benefit of the bacteria widely used in medicine, agriculture and biotechnology has determined the seriously omission in our control system today - the lack of standardization of studies for the safety assessment of bacteria with GRAS status . The moment has come when it became clear that this gap should be promptly filled and that only exact understanding the molecular base of interacting the microbes with eukaryotic cells can provide the foundation for effective practical developments in controlling the evolution of bacterial virulence and probiotic safety strategy, as well as the competent use of genetic technologies for monitoring the environment and managing infectious processes, thus avoiding the dramatic consequences of large-scale interventions in the micro and macro worlds

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Section: Data Acquisitionmentioning

confidence: 99%

Human and animal intestinal commensals and probiotics vs modern challenges of biosafety: problems and prospects

2023

ARI

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“…1,2 In recent decades, researchers investigated a great number of bacterial strains as potential therapeutic delivery systems, and it has been revealed that GEB have exceptional and comprehensive therapeutic effects in comparison to conventional techniques for preventing and treating certain diseases. [7][8][9][10] Recent scientific developments have led to the emergence of more advanced methods for designing drug delivery systems with precise targeting abilities. 1 Significantly, Escherichia coli, Lactobacillus, and Salmonella have emerged as the most commonly utilized bacterial chassis tools to construct various GEB that can treat a wide spectrum of disorders.…”

Section: Introductionmentioning

confidence: 99%