Modes of cannabis administration in the year prior to conception among patients in Northern California

Young-Wolff, Kelly C.; Adams, Sara R.; Brown, Qiana L.; Weisner, Constance; Ansley, Deborah; Goler, Nancy; Skelton, Kara; Satre, Derek D.; Foti, Tara R.; Conway, Amy

doi:10.1016/j.abrep.2022.100416

Cited by 7 publications

(10 citation statements)

References 22 publications

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“…To address key gaps in the evidence and overcome the limitations of previous human studies, we built upon our novel non-human primate (NHP) model of chronic cannabis exposure via edible THC consumption 24,25 . Edibles are the second most common mode of cannabis delivery 26 , especially in non-daily pregnant users 27 , and are often recommended by dispensaries to pregnant individuals for nausea 28 . NHPs and humans have similar fetal ontogeny 29,30 , placental structure 29,30 , and THC plasma disposition, resulting in observations that are directly translatable to human pregnancies 31 .…”

mentioning

confidence: 99%

Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model

Roberts

Schabel

Boniface

et al. 2022

Sci Rep

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Cannabis use in pregnancy is associated with adverse perinatal outcomes, which are likely mediated by the placenta. However, the underlying mechanisms and specific vasoactive effects of cannabis on the placenta are unknown. Our objective was to determine the impact of chronic prenatal delta-tetrahydrocannabinol (THC, main psychoactive component of cannabis) exposure on placental function and development in a rhesus macaque model using advanced imaging. Animals were divided into two groups, control (CON, n = 5) and THC-exposed (THC, n = 5). THC-exposed animals received a THC edible daily pre-conception and throughout pregnancy. Animals underwent serial ultrasound and MRI at gestational days 85 (G85), G110, G135 and G155 (full term is ~ G168). Animals underwent cesarean delivery and placental collection at G155 for histologic and RNA-Seq analysis. THC-exposed pregnancies had significantly decreased amniotic fluid volume (p < 0.001), placental perfusion (p < 0.05), and fetal oxygen availability (p < 0.05), all indicators of placental insufficiency. Placental histological analysis demonstrated evidence of ischemic injury with microinfarctions present in THC-exposed animals only. Bulk RNA-seq demonstrated that THC alters the placental transcriptome and pathway analysis suggests dysregulated vasculature development and angiogenesis pathways. The longer-term consequences of these adverse placental findings are unknown, but they suggest that use of THC during pregnancy may deleteriously impact offspring development.

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confidence: 99%

Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model

Roberts

Schabel

Boniface

et al. 2022

Sci Rep

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“…Indeed, women with preconception cannabis use account for the vast majority of women who use cannabis during pregnancy, 2 supporting the notion that a focus on preventing or reducing cannabis use prior to pregnancy could reduce prenatal use. 15 , 16 Research, patient education, and clinician training and communications that include a focus on the preconception period hold great promise to reduce the upward trajectory of prenatal cannabis use.…”

Section: Discussionmentioning

confidence: 99%

“… 4 A study in Northern California found that among the ~19% of pregnant women who endorsed preconception cannabis use, 27% reported using daily, and nearly half (46%) used ⩾1 mode of administration. 15 Importantly, Black and Hispanic women were more likely to report smoking cannabis and use of blunts during the preconception period, modes that are potentially associated with the greatest health risks. 15 Notably, nearly one-third (33.7%) of women with preconception cannabis use continue to use into pregnancy.…”

Section: Preconception Cannabis Use: An Overlooked Area For Interventionmentioning

confidence: 99%

Section: Preconception Cannabis Use: An Overlooked Area For Interventionmentioning

confidence: 99%

“…15 Importantly, Black and Hispanic women were more likely to report smoking cannabis and use of blunts during the preconception period, modes that are potentially associated with the greatest health risks. 15 Notably, nearly one-third (33.7%) of women with preconception cannabis use continue to use into pregnancy. 16 Available research shows that initiation of cannabis use during pregnancy is low, 16 indicating that the preconception period is an optimal time for cannabis use prevention and cessation interventions for women, including patient-provider discussions.…”

Section: Preconception Cannabis Use: An Overlooked Area For Interventionmentioning

confidence: 99%

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Preconception cannabis use: An important but overlooked public health issue

Skelton

Young-Wolff

2022

Womens Health (Lond Engl)

Self Cite

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Cannabis is the most commonly used federally illicit drug among pregnant women in the United States, and the prevalence and frequency of prenatal cannabis use are increasing. The preconception period – typically thought of as the 3-12 months immediately preceding pregnancy – is a distinct and critical period for women’s health that has often been overlooked when examining prenatal cannabis use. Given that substance use behaviors typically develop before pregnancy, and risk factors associated with prenatal cannabis use are often present prior to conception, preventive approaches to addressing prenatal cannabis use would benefit from focusing on women who use cannabis prior to pregnancy. In order to ensure preconception cannabis use is brought to the forefront of cannabis prevention efforts, we recommend additional research, patient education, and clinician training focused on preconception cannabis use.

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Exploring preferences for different modes of cannabis use during early pregnancy: A qualitative study

Mian

Foti

Green

et al. 2023

Addictive Behaviors

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Modes of cannabis administration in the year prior to conception among patients in Northern California

Cited by 7 publications

References 22 publications

Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model

Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model

Preconception cannabis use: An important but overlooked public health issue

Exploring preferences for different modes of cannabis use during early pregnancy: A qualitative study

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