Modes of Action of 1,8-Cineol in Infections and Inflammation

Abstract

The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear in the recent years that 1,8-Cineol spreads almost everywhere in the human body after its oral administration, from the gut to the blood to the brain. Its anti-microbial potential and even its anti-viral effects have been observed to include numerous bacteria and fungi species. Many recent studies help to better understand the cellular and molecular immunological consequences of 1,8-Cineol treatment in inflammatory diseases and further provide information concerning the mechanistic modes of action in the regulation of distinct inflammatory biosynthetic pathways. This review aims to present a holistic and understandable overview of the different aspects of 1,8-Cineol in infections and inflammation.

Comparative Evaluation of Volatile Organic Compounds in Two Bottle Gourd Accessions with Distinct Fruit Shapes

“…It also is involved with enhancing the shelf life of bananas [31]. Benzaldehyde (upregulated in USVL10A), the simplest aromatic aldehyde found in our data, is one of the most wide-spread volatiles that serves as a flavor, pollinator attractant [33], and antifungal compound [34,35]. Gao et al, 2018 observed a positive correlation between the level of benzaldehyde and the inhibition of M. fructicola in vitro [36] and was found effective to control the ring rot disease of potato caused by Clavibacter michiganensis subsp.…”

“…Similarly, α-pinene (upregulated in USVL10A) is a well-known representative of the monoterpenes group and found in many plants derived essential oils [27]. The monoterpenoid, 1,8-cineol is also a natural plant-derived healing agent and has mucolytic, anti-inflammatory properties due to which is widely used to treat inflammatory diseases [35]. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-leishmania, and analgesic effects [27].…”

Mixture design of α‐pinene, α‐terpineol, and 1,8‐cineole: A multiobjective response followed by chemometric approaches to optimize the antibacterial effect against various bacteria and antioxidant activity

“…The antimicrobial and anti‐inflammatory activities of 1,8‐cineole and its complex mechanisms of action in the regulation of various inflammatory biosynthetic pathways were reviewed by Pries et al. ( 2023 ).…”

Therapeutic Applications of Essential Oils from Native and Cultivated Ecuadorian Plants: Cutaneous Candidiasis and Dermal Anti-Inflammatory Activity

“…Finally, published research has documented that the monoterpene 1,8-Cineol reduces the expression of cytokines such as IL-4 and IL-6 in bronchial epithelial cells, as well as influences immune cells, where decreased expression in TNF-α, IL-1β, and IL-6 from monocytes, and also decreased the expression of IL-4 and IL-5 from lymphocytes. Even in acne, 1,8-Cineol-containing leaf extracts suppress the expression of IL-1β and IL-6 [73]. The large number of scientific publications that support the anti-inflammatory potential of α-phellandrene and 1,8-Cineol in the regulation of the inflammatory process and their promising application in the treatment of different inflammatory diseases agree with the results obtained in this investigation, in which the two essential oils that showed greater efficacy correspond to the species Dacryodes peruviana and Melaleuca armillaris, which are mainly composed of these two components.…”