Modernes Management von Hauttumoren

Dummer, Reinhard; Ludwig, Sabine; Kaufmann, Corina; Binkert, Andrea; Mangana, Joanna; Goldinger, Simone M.; Braun, Ralph

doi:10.4414/smf.2017.03009

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their growth can be self-limiting, or they can develop into invasive cSCC in approximately 1% of cases per year. In contrast, Bowen’s disease, which has dysplasia of all the layers of the epidermis, is already an intraepidermal carcinoma (carcinoma in situ) [ 3 , 4 , 5 ]. cSCC typically occurs on chronically sun-exposed skin areas such as the face, head, ear helix, back of the hands, and forearms.…”

Section: Introductionmentioning

confidence: 99%

The Immunohistochemical Assessment of Neoangiogenesis Factors in Squamous Cell Carcinomas and Their Precursors in the Skin

Daneluzzi

Jafari

Hunger

et al. 2022

JCM

View full text Add to dashboard Cite

Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. Well-limited forms can be easily treated with excision, but locally advanced cancers can, unfortunately, progress to metastasis. However, it is difficult to establish the prognosis for cutaneous squamous cell carcinoma and its potential to metastasize. Therefore, this study aimed to evaluate neoangiogenesis in cSCC, as it plays a major role in the dissemination of neoplasia. A literature review was performed on selected neoangiogenic factors (VEGF, ANG1/2, Notch1, CD31/34/105, EGF, etc.). Most of them, including VEGF, EGFR, and CD105, had more elevated levels in the advanced stages of the lesion. The same is true for Notch1, p53, and TGFβ, which are the most frequently mutated tumor suppressors in this type of skin cancer. In addition, the inhibition of some of these markers, using Ang1 analogs, inhibitors of EGFR, TRAF6, or combined inhibitors of EGFR and IGF-IR, may lead to a decrease in tumor size. In conclusion, this literature review identified diagnostic and prognostic markers, as well as possible factors that can be used for the targeted therapy of spinaliomas.

show abstract

Section: Introductionmentioning

confidence: 99%