Moderne Trennverfahren zur effizienten Aufarbeitung in der organischen Synthese

Abstract

Die kombinatorische Synthese [1,2] wird als eine der Schl¸s-seldisziplinen f¸r den konstanten Nachschub an chemischen Verbindungen angesehen, die auf biologische Aktivit‰t gegen¸ber der immens wachsenden Zahl biologischer Zielmolek¸le getestet werden kˆnnen. Zusammen mit dem Hochdurchsatz-Screening und einem effizienten Datenmanagement wird ihre Anwendung den Prozess der Wirkstoffentdeckung zweifelsohne beschleunigen. Urspr¸nglich konzentrierte sich die Kombinatorische Chemie auf die schnelle Synthese von hochkomplexen Gemischen mit winzigen An-

Cobalt(II) octanoate and cobalt(II) perfluorooctanoate catalyzed atom transfer radical polymerization of styrene in toluene and fluorous media—A versatile route to catalyst recycling and oligomer formation

“…Preferably, both solvents are immiscible at ambient temperature, but miscible at elevated temperatures, thus affording homogeneous catalysis at elevated temperature and recovery of fluorine‐containing solvents and perfluoroalkyl‐tagged ligands and complexes at lower temperature. This concept was developed by Horvath and Rabai62, 63 as a very versatile synthetic method in organic synthesis involving small molecules 64–66. But recently, the use of fluorinated organic compounds in living radical polymerization has become popular as well 67.…”

“…This concept was developed by Horvath and Rabai 62,63 as a very versatile synthetic method in organic synthesis involving small molecules. [64][65][66] But recently, the use of fluorinated organic compounds in living radical polymerization has become popular as well. 67 For example, De Campo used CuCl/Pentakis-N- (4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1,4,7-triazaheptane for atom transfer radical addition reactions and cyclizations to obtain products with low copper contamination.…”

Fluorous Biphasic Catalysis without Perfluorinated Solvents: Application to Pd-Mediated Suzuki and Sonogashira Couplings

“…A further aspect is the straightforward recovery and reuse of the catalyst. Generally, simplification of workup protocols and handling of small amounts of catalysts is especially important in multiparallel and automated synthesis in combinatorial chemistry 8. 9…”

Sulfonated Polyethylene Glycol (PEG-SO3H) as Eco-Friendly and Potent Water Soluble Solid Acid for Facile and Green Synthesis of 1,8-Dioxo-Octahydroxanthene and 1,8-Dioxo-Decahydroacridine Derivatives

“…These species allow rapid and simplified procedures, and their use has become widespread in solution-phase organic synthesis and combinatorial chemistry (41). In this context, soluble polymers have recently been the subject of an intense research activity; allowing the reaction to be carried out in homogeneous solution they would secure higher chemical and stereochemical efficiency than insoluble polymer (42). Among the soluble polymeric matrixes employed, poly(ethylene glycol)s (PEGs) are the most successful.…”