Modern Veterinary Blood Banking Practices and their Applications in Companion Animal Practice

Feldman, Bernard F.; Kristensen, Annemarie T.

doi:10.1016/s0195-5616(95)50151-2

Cited by 24 publications

(28 citation statements)

References 2 publications

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“…Alloantibodies will appear following the first transfusion in DEA 1 negative recipient dogs receiving positive DEA 1 red blood cells (RBCs) within 4–14 days [11–14]. Sensitization of the recipient and production of alloantibodies can result in a severe acute hemolytic transfusion reaction and even death if a second DEA 1 positive RBC transfusion is administered to the same patient [15–17]. The risk of alloantibody production and transfusion reactions against antigens other than DEA 1 is not yet well defined [2] and there is no documented clinical evidence of a hemolytic reaction caused by DEA 1.2, 3, 5, and 7 in mismatched transfusions [18].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy

Valentin

Gavazza

Lubas

2017

Veterinary Medicine International

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The study aim was to establish the prevalence of DEA 1, the most immunogenic and clinically important blood group in canine blood transfusion, in 7,414 dogs from Italy. The potential sensitization risk following a first transfusion and the acute reaction risk following a second transfusion given without a cross-matching and blood typing test were also calculated. Dogs tested were purebred (4,798) and mongrel (2,616); 38.8% were DEA 1 negative and 61.2% were DEA 1 positive. High prevalence for DEA 1 positive blood type was found in Ariegeois and English Setter, whereas German Shepherd and Boxer had higher DEA 1 negative blood type. Breeds with blood type never reported before included French Brittany Spaniel and Pug showing a high prevalence of DEA 1 positive type, while French Bulldog and West Highland White Terrier were more often DEA 1 negative. Just 48.8% of purebred and 13.9% of mongrel dogs were considered as prospective blood donors based upon their blood type. Most of the breeds had a sensitization risk of 20.0–25.0%. Rottweiler and Ariegeois had less risk of sensitization (9.4 and 4.2%) and the minor risk of an acute transfusional reaction (0.9–0.2%). The prevalence of DEA 1 positive and negative dogs in Italy agrees with most of the data already reported in the literature.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy

Valentin

Gavazza

Lubas

2017

Veterinary Medicine International

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“…Development of methods for low-temperature preservation and long-term storage of red blood cells (RBC) of domestic animals, particularly dogs and cats, is one of the actual problems in veterinary medicine [1,2,3]. The acute interest in this issue is determined by the growth of hematological diseases in these animals, low number of donor individuals, complexity of selection of blood according to phenotypic characteristics, as well as limited storage period at 4°C [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Possibility of Cryopreservation of Feline and Canine Erythrocytes by Rapid Freezing with Penetrating and Non-Penetrating Cryoprotectants

et al. 2017

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Efficient application of veterinary blood transfusion approaches for small companion animals requires readily available supply of the donor material. This can be achieved by developing of effective biobanking technologies allowing long-term storage of donor blood components via cryopreservation. Transfusion of an erythrocyte concentrate allows the successful correction of various hematological pathologies, severe bleeding, and etc. While in the past there were several approaches to cryopreserve red blood cells of dogs, to our knowledge there is virtually no data on cryopreservation of feline erythrocytes. In this paper, we performed a comprehensive parameter optimization for low temperature storage of RBCs of both species. Here, the efficiency of single-component and multicomponent cryoprotective media as well as necessary time of pre-incubation with penetrating and non-penetrating cryoprotectants prior to rapid freezing is analyzed. This study showed that glycerol was not sufficient for cryopreservation of red blood cells of the studied species under the investigated conditions. Application of 10% (v/v) ME2SO allowed for a significant reduction of canine and feline erythrocytes hemolysis after thawing. 17.5% hydroxyethyl starch demonstrated the highest cryoprotective activity for both species. It was found that dog RBCs should be incubated in cryoprotective media for 30 min at 22°C prior to freezing, while for cat RBCs 20 min is sufficient. Combination of CPAs was less effective. Presented data may be considered in further studies in veterinary transfusion and blood banking optimization.

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“…Administration of fresh donor blood within four hours of collection to the recipient (Hoefer 1992, Hillyer 1995, Lichtenberger 2004) seems to pose little clinical risk in ferrets (Hohenhaus 2004, Lichtenberger 2004), even without cross-matching as blood-groups of the kind found in other mammals do not appear to exist on ferret red blood cells (RBC) (Manning and Bell 1990). Although blood banking is a common method for storage of canine and feline blood (Feldman and Kristensen 1995), it is not currently practised with ferret blood.…”

Section: Introductionmentioning

confidence: 99%

Assessment of a blood preservation protocol for use in ferrets before transfusion

et al. 2014

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Blood transfusion has been described in ferrets as a treatment for oestrus-associated anaemia and as a life-saving therapy following trauma, iatrogenic (usually surgery-induced) anaemia, autoimmune haemolytic anaemia and pure red cell aplasia. Although blood banking is a common method for storage of feline and canine blood it is not currently done with ferret blood. The aim of this study was to determine the shelf-life of ferret blood using the anticoagulant citrate-phosphate-dextrose-solution with adenine (CPDA). Two male ferrets were used as blood donors. From each ferret, 6 ml of blood was taken from the cranial vena cava and stored in 10 ml polyethylene terephthalate (PET) blood tubes containing 1 ml of CPDA solution. Blood was taken from each ferret once per month for five months. These 10 blood samples were stored in a laboratory refrigerator at 4°C for four weeks. Biochemical (glucose, pH, lactate, potassium, sodium) and haematological (haematocrit, light microscopic blood smear examination) analyses were performed on the stored blood at days 0, 7, 14, 21 and 28. Biochemical analyses revealed a progressive decrease from day seven in the stored blood pH, glucose and sodium, with a concomitant increase in lactate and potassium. These results are attributable to the ongoing metabolism and deterioration of the red blood cells (RBC) while in storage, and are more rapid than described for human or canine stored blood. Haematological analyses revealed a progressive elevation of the haematocrit due to the appearance of hypochromic red blood cells and echinocytes beginning at day 7. Haemolysis was observed in the microhaematocrit capillary tube sample by day 21, and microscopic clots were visible on the blood smear by day 28. The low blood pH and the appearance of many hypochromic RBCs and some echinocytes from day 7 in CPDA-stored ferret blood, suggest stored ferret blood has a short shelf-life when compared with stored human or canine blood. We recommend that ferret blood stored in CPDA should not be used for transfusion after seven days of storage at 4°C.

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Modern Veterinary Blood Banking Practices and their Applications in Companion Animal Practice

Cited by 24 publications

References 2 publications

Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy

Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy

Exploring the Possibility of Cryopreservation of Feline and Canine Erythrocytes by Rapid Freezing with Penetrating and Non-Penetrating Cryoprotectants

Assessment of a blood preservation protocol for use in ferrets before transfusion

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