“…CKR-3 has features which distinguish it from other C-C chemokine receptors and which suggest a role in the selective eosinophil infiltration into tissues. First, it is expressed at high levels on eosinophils, 40,000 (50) to 400,000 (49) receptors per cell, compared to CKR-1 and CKR-2, which are expressed on monocytes and T cells usually at <3,000 receptors per cell (37,51). This 10-100-fold excess of CKR-3 over CKR-1 and CKR-2 is consistent with the high potency of CKR-3 ligands as eosinophil chemoattractants.…”