Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies

Lüders, Hans; Amina, Shahram; Baumgärtner, Christopher; Benbadis, Selim R.; Bermeo‐Ovalle, Adriana; Devereaux, Michael W.; Diehl, Beate; Edwards, Jonathan; Baca-Vaca, Guadalupe Fernandez; Hamer, Hajo M.; Ikeda, Akio; Kaiboriboon, Kitti; Kellinghaus, Christoph; Koubeissi, Mohamad Z.; Lardizabal, David; Lhatoo, Samden D.; Lüders, Jürgen; Mani, Jayanti; Mayor, Luis Carlos; Miller, Jonathan P.; Noachtar, Soheyl; Pestana, Elia; Rosenow, Felix; Sakamoto, Américo Ceiki; Shahid, Ayaz; Steinhoff, Bernhard J.; Syed, Tanvir U.; Tanner, Adriana; Tsuji, Sadatoshi

doi:10.1111/j.1528-1167.2011.03376.x

Cited by 48 publications

(52 citation statements)

References 17 publications

(43 reference statements)

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“…However, there are three major topics that also emerge in this study. First, for many authors this new classification scheme is not the thorough revision that was hoped for (Panayiotopoulos, 2011;L€ uders et al, 2012;Panayiotopoulos, 2012). This is especially the case for the classification of epilepsies and epileptic syndromes.…”

Section: Discussionmentioning

confidence: 99%

“…Most appreciated the attempt of the ILAE to update the classification of seizures and epilepsies consistent with the current level of knowledge (Beghi, 2011;Mosh e, 2011;L€ uders et al, 2012). However, many negative comments, remarks, and tips for improvement have been published as well (Shinnar, 2010;Beghi, 2011;Devinsky & Najjar, 2011;G omez-Alonso & BellasLamas, 2011;Panayiotopoulos, 2011;Wong, 2011;L€ uders et al, 2012;Noachtar & R emi, 2012;Panayiotopoulos, 2012).…”

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confidence: 99%

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Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children

et al. 2013

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Summary Purpose Accurate classification of epileptic seizures, epilepsies, and epilepsy syndromes is mandatory in both clinical practice and epilepsy research. In 2010, the International League Against Epilepsy (ILAE) proposed a new classification scheme. The aim of this study is to determine whether application of this new classification for epileptic seizures and epilepsies has improved interobserver agreement compared to the classification schemes used previously. Methods Three pediatric neurologists working in different university hospitals retrospectively classified seizures and epilepsies of 80 children (165 seizures) referred to the University Center Utrecht, based on anonymized data, according to the newly proposed (2010) as well as the old (1981/1989) ILAE classification schemes. We determined interobserver agreement of the application of both ILAE classifications with kappa statistics. Key Findings Interobserver agreement of the new classification for seizures and epilepsies is comparable to that of previous classifications. There is substantial agreement on the newly introduced etiologic axis. Significance Introduction of the new epilepsy classification has not substantially improved interobserver agreement. This study shows which items cause considerable interobserver disagreement and therefore need specification.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children

et al. 2013

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“…The screening of ion channel genes, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, might disclose the link between arrhythmias and seizures 4. This study and imaging techniques could explain important details of this disease 5 6…”

Section: Descriptionmentioning

confidence: 99%

Coexistence of seizure episodes and symptomatic sinoatrial arrest occurring in two sisters suggests an underlying cardioneuronal channelopathy

et al. 2013

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“…Epilepsy is a complex disorder of brain electrical activity that results in recurrent convulsions. [1,2] Seizures occur due to abnormal neuronal discharge. Oxidative stress is one of the major role players in seizure genesis.…”

Section: Introductionmentioning

confidence: 99%

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Kaushik

2017

IJGP

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Epilepsy or Apasmara is a common chronic neurological disorder affecting millions worldwide. Abnormal neuronal discharge occurs during seizures. A person with epilepsy is loaded with a variety of synthetic anticonvulsants, which has associated toxicities and degenerative effects on some essential biochemicals and brain antioxidant enzymes on prolonged use. Ketogenic and Atkins diet are sometimes prescribed by neurologists as adjuvant with modern antiepileptics, but their limited use and associated side effects have led to focus on some alternatives. Nidanparivarjan, Shodhan chikitsa, Bahiparimarjan, Rasayana chikitsa, Sattvavajaya and Avasthika chikitsa are basic approaches for treatment of disorders or ailments in Ayurveda. Rasayana chikitsa is preferred for the long-term management of epilepsy, which involves the use of Medhya Rasayana which is a collection of herbs in minute quantities such as Mandukaparni, Yashtimadhu, Guduchi, Tinospora, Ashwagandha, Shankhpushpi, Vacha, and Brahmi. Sarasvata churna is an ayurvedic formulation and as mentioned by Bhavaprakasha and Ayurvedic Formulary of India and is a compound ayurvedic formulation containing Saussurea lappa, Withania somnifera, Rock salt, Carum roxburghianum, Cuminum cyminum, Carum carvi, Piper longum, Piper nigrum, Zingiber officinale, Cissampelos pareira, Convolvulus pluricaulis, Acorus calamus, and Bacopa monnieri. Besides possessing tremendous curing potential, Sarasvata churna is not being prescribed by neurologists for the treatment of epilepsy due to lack of animal and clinical safety data. In this study, the individual component drugs of Sarasvata churna are intensively investigated on pharmacological basis for their respective role in overcoming epilepsy so as to understand the actual mechanisms behind the potential of this thousand years old remedy for epilepsy.

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Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies

Cited by 48 publications

References 17 publications

Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children

Interobserver agreement of the old and the newly proposed ILAE epilepsy classification in children

Coexistence of seizure episodes and symptomatic sinoatrial arrest occurring in two sisters suggests an underlying cardioneuronal channelopathy

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