Modern techniques of surface geometry modification for the implants based on titanium and its alloys used for improvement of the biomedical characteristics

Zemtsova, E. G.; Arbenin, A. Yu.; Valiev, Ruslan Z.; Смирнов, В. М.

doi:10.1016/b978-0-12-812456-7.00006-8

Cited by 8 publications

(9 citation statements)

References 70 publications

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“…Treatments on surfaces of Ti and Ti alloys have also been reported in the literature. [19][20][21][22] Notably, one useful and straightforward way for modifying surfaces was performed by using an acid medium to produce a uniform micron, and submicron porosity on the surface and, subsequently, an alkali treatment was performed to produce either a sponge or coral-like nanotopographic substrate enabling modulation of cellular interactions. 19 The work herein aimed to establish a synergistic processing method for Ti alloys, combining SPD processing followed by surface modification, with the expectancy of improved mechanical properties of the material and biological responses.…”

Section: Introductionmentioning

confidence: 99%

<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>

Oliveira

Toniato

Ricci

et al. 2019

IJN

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Background: Nanophase surface properties of titanium alloys must be obtained for a suitable biological performance, particularly to facilitate cell adhesion and bone tissue formation. Obtaining a bulk nanostructured material using severe plastic deformation is an ideal processing route to improve the mechanical performance of titanium alloys. By decreasing the grain size of a metallic material, a superior strength improvement can be obtained, while surface modification of a nanostructured surface can produce an attractive topography able to induce biological responses in osteoblastic cells. Methods: Aiming to achieve such an excellent synergetic performance, a processing route, which included equal channel angular pressing (ECAP), hot and cold extrusion, and heat treatments, was used to produce a nanometric and ultrafine-grained (UFG) microstructure in the Ti-6Al-7Nb alloy (around of 200 nm). Additionally, UFG samples were surface-modified with acid etching (UFG-A) to produce a uniform micron and submicron porosity on the surface. Subsequently, alkaline treatment (UFG-AA) produced a sponge-like nanotopographic substrate able to modulate cellular interactions. Results: After several kinds of biological tests for both treatment conditions (UFG-A and UFG-AA), the main results have shown that there was no cytotoxicity, expressed alkaline phosphatase activity and total protein amounts without statistical differences compared to control. However, the UFG-AA samples presented an attractive effect on the cell membranes, and cell adhesions were preferentially induced as compared with UFG-A. Both conditions demonstrated cell projections, but for UFG-AA, cells were more widely dispersed, and more quantities of filopodia formation could be observed. Conclusion: Herein, the reasons for such behaviors are discussed, and further results are presented in addition to those mentioned above.

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Section: Introductionmentioning

confidence: 99%

<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>

Oliveira

Toniato

Ricci

et al. 2019

IJN

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“…Recently, materials scientists have been exploring possibilities of improved interaction of nanostructured materials with body tissues, for instance bones. In this respect, surface modifications of bulk nanomaterials demonstrate encouraging results [17,18,20,21]. These improvements provide the possibility for development and design of implantable medical devices that perform better and provide improved functionality in comparison to their counterparts manufactured from common coarse-grained materials.…”

Section: Introductionmentioning

confidence: 94%

“…Nanostructuring of metallic materials increases material strength due to work hardening and grain refinement [13,14], consequently, fatigue life can be also significantly increased by microstructure refinement [15]. Understanding material processing by SPD techniques is essential for designing of medical devices with improved functionality as it not only improves mechanical properties but also affects corrosion and biomedical properties [16][17][18]. Improved strength and enhanced biomedical response of a nanostructured material can be efficiently used in dental implants; a stent of such permanent implant manufactured from nanostructured Ti can be significantly smaller due to the increased strength and therefore less harmful for a patient [19].…”

Section: Introductionmentioning

confidence: 99%

Developing Nanostructured Ti Alloys for Innovative Implantable Medical Devices

et al. 2020

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Recent years have witnessed much progress in medical device manufacturing and the needs of the medical industry urges modern nanomaterials science to develop novel approaches for improving the properties of existing biomaterials. One of the ways to enhance the material properties is their nanostructuring by using severe plastic deformation (SPD) techniques. For medical devices, such properties include increased strength and fatigue life, and this determines nanostructured Ti and Ti alloys to be an excellent choice for the engineering of implants with improved design for orthopedics and dentistry. Various reported studies conducted in this field enable the fabrication of medical devices with enhanced functionality. This paper reviews recent development in the field of nanostructured Ti-based materials and provides examples of the use of ultra-fine grained Ti alloys in medicine.

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“…Nonetheless, it has been demonstrated that nanoscale topography outperforms macro and micro-scale surface features towards augmenting cellular functions [69]. More recently, at has been proposed that a combination of different topographic features at the macro, micro, and nanoscale with local drug delivery functions can further enhance the biological, chemical, tribological, and mechanical performance of Ti bone implants [70][71][72][73].…”

Section: Metals and Titanium As A Bio-metamaterialsmentioning

confidence: 99%

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

et al. 2020

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Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way. This study used the QbD system to explore the Quality Target Product Profile and Ideal Quality Attributes of additively manufactured titanium porous scaffolds for bone regeneration with a biomimetic approach. For this purpose, a total of 807 experimental results extracted from 50 different studies were benchmarked against proposed target values based on bone properties, governmental regulations, and scientific research relevant to bone implants. The scaffold properties such as unit cell geometry, pore size, porosity, compressive strength, and fatigue strength were studied. The results of this study may help future research to effectively direct the design process under the QbD system.

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Modern techniques of surface geometry modification for the implants based on titanium and its alloys used for improvement of the biomedical characteristics

Cited by 8 publications

References 70 publications

<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>

<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>

Developing Nanostructured Ti Alloys for Innovative Implantable Medical Devices

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

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Modern techniques of surface geometry modification for the implants based on titanium and its alloys used for improvement of the biomedical characteristics

Cited by 8 publications

References 70 publications

<p>Biological response of chemically treated surface of the ultrafine-grained Ti&ndash;6Al&ndash;7Nb alloy for biomedical applications</p>

<p>Biological response of chemically treated surface of the ultrafine-grained Ti&ndash;6Al&ndash;7Nb alloy for biomedical applications</p>

Developing Nanostructured Ti Alloys for Innovative Implantable Medical Devices

Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

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<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>

<p>Biological response of chemically treated surface of the ultrafine-grained Ti–6Al–7Nb alloy for biomedical applications</p>