Modern Phytomedicine in Treating Diabetic Foot Ulcer: Progress and Opportunities

Ali-Seyed, Mohamed; Siddiqua, Ayesha

doi:10.1007/978-981-15-7639-3_18

Cited by 4 publications

(4 citation statements)

References 193 publications

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“…Recent years witnessed numerous plants with antidiabetic, hypoglycemic, and anti-hyperglycemic actions with α-amylase and α-glucosidase inhibition [31]. Approximately 509 plant species belong to 140 genera, among them, nearly 10 or more species exhibiting anti-diabetic effects [22], [31], [79] as many plant derivatives/NPs are available and do not involve strenuous pharmacological synthesis, appears extremely warranted. Herbal drug leads and NPs have no/less toxicity with no significant side effects/ ramifications are notable therapeutic options for the treatment of diabetes worldwide [80], [81].…”

Section: Discussionmentioning

confidence: 99%

“…It is projected the global incidence of DM may augment gradually from 4% in 1995 to 5.4% or more in the coming years [22] and the surge go beyond 642 million in the next two decade alarmed by the WHO. This major burden will emerge more in the developing countries (170%), whereas 42% increase in the developed countries [23], [24], [25].…”

Section: Global Incidence Of Type 2 Diabetesmentioning

confidence: 99%

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Anti-diabetic Attributes of Desert Plant Retama: A Mini Review on its Traditional Uses and Potential Chemical Constituents

Elodemi,

Siddiqua,

Seyed

2023

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus (DM) is a fast-growing metabolic disorder, which affect millions around the world mostly people from developing nations. The rise of diabetes is further set to rise more in the coming years in all inhabited continents of the world. DM mainly attributed for food and lifestyle changes, less or no physical activity, obese, overweight, and major socioeconomic changes. In recent years, herbal medicine is incredibly growing because many natural products exhibit less or no side effects. It is well-established that nature-derived products protect β-cells and decrease blood glucose. AIM: We aimed to explain anti-diabetic attributes, traditional uses, and potential chemical constituents of desert plant retama. RESULTS: Numerous previous studies support the use of plant derived bioactive substances for human and animal disease therapy and reinforce their importance as a potential source of novel drug candidates. In this line a flowering bush, belong to the genus “Retama” (Fabaceae) are in use of conventional remedy in the Mediterranean basin for various diseases including DM. This potential plant genus has a great medical and socioeconomic importance and provides crucial evidence for its anti-diabetic therapeutic potential. The present review collected various documented information using the following searching engines such as PubMed, Science direct, and Google scholar. We limit our search only to English written documents for the last few decades until date. For data mining, the following MeSH words used in the databases: Retama, diabetes, phytoconstituents, pharmacological potential, anti-diabetic, insulin, in vivo, and in vitro. CONCLUSION: The outcome of this review may set new prospects for the DM patients, along with other standard medication and provide an overall insight to the well-being at the regional and global level.

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Section: Discussionmentioning

confidence: 99%

Section: Global Incidence Of Type 2 Diabetesmentioning

confidence: 99%

Anti-diabetic Attributes of Desert Plant Retama: A Mini Review on its Traditional Uses and Potential Chemical Constituents

Elodemi,

Siddiqua,

Seyed

2023

Open Access Maced J Med Sci

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“…Despite the availability of numerous medicinal plants and associated active phytoconstituents, as well as pharmaceutical preparations for the management of diabetes, additional medicinal plants with greater antidiabetic efficacy must be sought. The significance of traditional phytomedicines as one of the treatment strategies for DFU should be seriously considered, particularly in low-income nations [195]. The effects of plant extracts on diabetic wounds should be scientifically investigated in order to develop potential adjunct medications for wound treatment.…”

Section: Future Strategies Used To Overcome the Burden Of Diabetic Footmentioning

confidence: 99%

Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies

et al. 2022

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Diabetes mellitus, a major cause of mortality around the globe, can result in several secondary complications, including diabetic foot syndrome, which is brought on by diabetic neuropathy and ischemia. Approximately 15% of diabetic patients suffer from diabetic foot complications, and among them 25% are at risk of lower limb amputations. Diabetic foot ulcers are characterized as skin lesions, gangrene, or necrosis, and may develop due to several reasons, including hyperglycemia and slower wound healing in diabetic patients. A management protocol involving wound cleaning, oral antibiotics, skin ointments, and removing dead tissue is currently followed to treat diabetic foot ulcers. In severe cases, amputation is performed to prevent the infection from spreading further. The existing therapy can be costly and present adverse side effects. Combined with a lack of vascular surgeons, this ultimately results in disability, especially in developing nations. There is a growing interest in the use of alternative therapies, such as medicinal plants, to discover more efficient and affordable treatments for diabetic foot syndrome. It has been observed that treatment with numerous plants, including Carica papaya, Annona squamosa, Catharanthus roseus, and Centella asiatica, promotes wound healing, reduces inflammation, and may decrease the number of amputations. However, little information is currently available on the prevention and management of diabetic foot ulcers, and additional research is necessary to completely understand the role of alternative therapies in the treatment of diabetic foot complications.

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“…Peripheral diabetic complications, such as neuropathy, angiopathy, and the infections of the DFU extend the inflammatory stage with the overexpression of inflammatory cytokines such as IL-1β [ 22 ], IL-6 [ 23 ], TNF-α [ 23 ], NF-κβ [ 24 ], and MCP-1 [ 25 ], which increase the tissue damage, imposing either a proliferative or maturation stage, which results in retarding the diabetic wound healing [ 26 ]. Several medicinal herbal extracts have achieved reasonable therapeutic goals regarding DFU infection [ 27 ]. S. aromaticum is one of those herbs, belong to the family Myrtaceae, and exerts broad-spectrum antibacterial activity against MDR bacteria [ 28 ] and has other beneficial biological activities such as anti-inflammatory, antioxidant, and antibacterial effects [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

The Healing Capability of Clove Flower Extract (CFE) in Streptozotocin-Induced (STZ-Induced) Diabetic Rat Wounds Infected with Multidrug Resistant Bacteria

et al. 2022

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Treatment of diabetic foot ulcer (DFU) is of great challenge as it is shown to be infected by multidrug resistant bacteria (MDR bacteria). Sixty four bacterial isolates were isolated from DFU cases; antibiotic susceptibility tests were carried out for all of them. One bacterial isolate (number 11) was shown to resist the action of 8 out of 12 antibiotics used and was identified by both a Vitek-2 system and 16S rRNA fingerprints as belonging to Proteus mirabilis, and was designated Proteus mirabilis LC587231 (P. mirabilis). Clove flower extract (CFE) inhibited distinctively the P. mirabilis bacterium obtained. GC-MS spectroscopy showed that this CFE contained nine bioactive compounds. The effect of CFE on wound healing of Type 1 diabetic albino rats (Rattus norvegicus) was studied. The results indicated that topical application of CFE hydrogel improved wound size, wound index, mRNA expression of the wound healing markers (Coli1, MMP9, Fibronectin, PCNA, and TGFβ), growth factor signaling pathways (PPAR-α, PGC1-α, GLP-1, GLPr-1, EGF-β, EGF-βr, VEGF-β, and FGF-β), inflammatory cytokine expression (IL8, TNFα, NFKβ, IL1β, and MCP1), as well as anti-inflammatory cytokines (IL4 & IL10), pro-apoptotic markers (FAS, FAS-L, BAX, BAX/BCL-2, Caspase-3, P53, P38), as well as an antiapoptotic one (BCL2). Furthermore, it improved the wound oxidative state and reduced the wound microbial load, as the cefepime therapy improved the wound healing parameters. Based on the previous notions, it could be concluded that CFE represents a valid antibiotics alternative for DFU therapy since it improves diabetic wound healing and exerts antibacterial activity either in vitro or in vivo.

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Modern Phytomedicine in Treating Diabetic Foot Ulcer: Progress and Opportunities

Cited by 4 publications

References 193 publications

Anti-diabetic Attributes of Desert Plant Retama: A Mini Review on its Traditional Uses and Potential Chemical Constituents

Anti-diabetic Attributes of Desert Plant Retama: A Mini Review on its Traditional Uses and Potential Chemical Constituents

Hyperglycaemia-Linked Diabetic Foot Complications and Their Management Using Conventional and Alternative Therapies

The Healing Capability of Clove Flower Extract (CFE) in Streptozotocin-Induced (STZ-Induced) Diabetic Rat Wounds Infected with Multidrug Resistant Bacteria

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