Modern Outlooks on Pathogenesis, Clinical Picture, Diagnosis and Management of Acne Vulgaris in Children and Adolescents

Araviiskaia, Elena; Мурашкин, Н. Н.; Намазова-Баранова, Л. С.; Иванов, Р. А.

doi:10.15690/vsp.v19i6.2141

Cited by 5 publications

(1 citation statement)

References 99 publications

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“…Лечение детей с 9 лет является ещё одним показанием для фиксированной комбинации адапалена и бензоила пероксида -единственного на сегодняшний день препарата, зарегистрированного на территории России для терапии акне в данной возрастной группе [32][33][34]. Кроме того, препарат рекомендуется также для профилактики формирования рубцов постакне: применение препарата 1 раз/сут в течение 6 месяцев снижает риск образования новых атрофических рубцов и улучшает общую выраженность рубцов при акне [35,36].…”

Section: исследование эффективности препаратов в работах российских и...unclassified

Differentiated approach to external acne therapy

Olisova

2024

Russian Journal of Skin and Venereal Diseases

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Acne is a serious medical and social problem due to the widespread prevalence of the disease. Localized mainly on the face, acne leads to the development of disorders in the psycho-emotional sphere, significantly reducing the quality of life. The aim of the study was to study the effectiveness and safety of Epiduo/Effezel gel (adapalene 0.1% and benzoyl peroxide 2.5%) in patients with papulopustular acne. The Clinic of Skin and Sexually Transmitted Diseases of the Clinical Hospital No. 2 of Sechenov University has accumulated extensive experience in the treatment of acne. In the diagnostic and treatment department, patients with mild to moderate acne receive consultations and treatment almost every day. A dermatological examination is carried out visually with a simple count of eruptive elements: papules, pustules and nodes, on the basis of which the degree of severity is determined. Patients with severe forms of acne receive systemic retinoids with corrective therapy until a certain cumulative dose is reached, and then patients receive topical maintenance therapy intermittently for 12 months. Despite the development of effective methods for treating this dermatosis, patient adherence to treatment remains low. This is due, first of all, to the duration of therapy, not always the rapid achievement of the expected result, and to the development of psycho-emotional disorders in patients. In the latest edition of the Russian Society of Dermatovenerologists and Cosmetologists clinical guidelines for the treatment of mild to moderate acne with a high level of evidence A1, it is recommended to use benzoyl peroxide and a fixed combination of adapalene and benzene peroxide. When prescribing benzene peroxide (Baziron AS), we observed the best results in clearing the skin of rashes in the presence of a few papulopustular elements in the clinical picture due to the triple action of benzoyl peroxide ― antimicrobial, keratolytic and sebostatic. In our experience, it usually took 4 to 6 weeks to achieve clinical remission, and we did not note a single case of the development of bacterial resistance during treatment. For moderately widespread papulopustular acne rashes of moderate severity, as well as in cases of severe forms of the disease, when it is impossible to prescribe systemic isotretinoin or there is a tendency to scarring of the primary elements, we used a fixed combination of adapalene 0.1% and benzoyl peroxide 2.5% (Effezel) with anti-inflammatory, antimicrobial, keratolytic, sebostatic, comedolytic and anticomedogenic effects. In the arsenal of dermatologists and cosmetologists there are drugs for the external treatment of mild to moderate papulopustular acne with a high level of evidence. Thus, for papulopustular acne with a few inflammatory (papules and pustules) rashes, benzoyl peroxide gel may be recommended. For moderately widespread papulopustular acne with the presence of comedones (moderate severity), a fixed combination of adapalene and benzoyl peroxide can be recommended as the first line of therapy.

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Section: исследование эффективности препаратов в работах российских и...unclassified

Differentiated approach to external acne therapy

Olisova

2024

Russian Journal of Skin and Venereal Diseases

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Papulopustular Acne: Differential Diagnosis and Therapy Algorithms in Prepubertal and Pubertal Age

Murashkin,

Leonova,

Opryatin

et al. 2023

Vopr. sovr. pediatr.

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Antibiotic therapy of acne and antibiotic resistance: State of the art

Smirnova,

Khazhomiya,

Petunova

et al. 2023

Russian Journal of Skin and Venereal Diseases

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Acne is one of the most common dermatoses, with 117 million people diagnosed with the disease each year. Acne has a complex multifactorial genesis, including genetic predisposition and the influence of exposome factors. The direct mechanisms of the disease are associated with increased sensitivity of sebaceous glands to androgens, sebum hyperproduction, impaired keratinization at the mouth of hair follicles, and inflammation, in the induction of which Propionobacterium acnes is involved. The treatment of acne is complex, and one of its strategies is to regulate the number and activity of P. acnes through the use of antibacterial therapy. Antibacterial drugs have been used in the treatment of acne since the 1950s. They are included in a number of clinical guidelines and expert consensus documents for the treatment of the disease. However, the use of antibacterial drugs is limited by the formation of antibiotic resistance. Antibacterial drugs resistance in acne was first noted in the 1970s and was labeled as a global problem in the 2000s. The rapid increase in antibiotic resistance has prompted the development of strategies to prevent it and limit the use of antibacterial drugs in acne. This review presents information on the efficacy and place of antibacterial drugs in the treatment of acne, the epidemiology and mechanisms of antibiotic resistance, and strategies to overcome it. The authors consider and substantiate the effectiveness of a fixed combination of adapalene 0.1% and benzoyl peroxide 2.5%, based on the effect on the key links in the pathogenesis of acne, synergism of action and suppression of even antibiotic-resistant strains of P. acnes.

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Modern Outlooks on Pathogenesis, Clinical Picture, Diagnosis and Management of Acne Vulgaris in Children and Adolescents

Cited by 5 publications

References 99 publications

Differentiated approach to external acne therapy

Differentiated approach to external acne therapy

Papulopustular Acne: Differential Diagnosis and Therapy Algorithms in Prepubertal and Pubertal Age

Antibiotic therapy of acne and antibiotic resistance: State of the art

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