Modern Opportunities of Radionuclide Methods for Diagnosis of  Inflammatory Processes in the Myocardium

Сазонова, С. И.; Ilyushenkova, Julia N.; Lishmanov, Yu. B.

doi:10.21569/2222-7415-2017-7-2-142-150

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…These factors cause projection overlays and motor artifacts that interfere with the sought image. Although these difficulties can be eliminated by using multimodal imaging techniques and gating methods, the problem of visualizing the pools of blood located in large vascular cavities has not been fully resolved [ 17 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…The scanning time was 400–600 s, depending on the patient’s body weight. Immediately before the first examination, a radioisotope marker was attached to the patient’s chest (3 rd intercostal space on the left along the mid-clavicular line), on top of which an ECG electrode — a radio-contrast marker — was glued ( Figure 1 ) [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…In its original mode, however, these techniques cannot be used to visualize inflammation in the TA wall, since the radioactivity of the blood pooled in cavities of large vessels “overlaps” the local RP radioactivity in adjacent tissues [ 17 – 20 ]. We hypothesized that the adjustment of this technique [ 23 ] by subtracting the background radiation, also known as the background correction method, would eliminate artifacts from the radioactivity of the aortic blood pool, improve the quality of visualization of the aortic wall, and identify foci of inflammation, which accumulate 99m Tc-pyrophosphate.…”

Section: Introductionmentioning

confidence: 99%

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Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Ilyushenkova¹,

Панфилов²,

Саушкин³

et al. 2021

Sovrem Tehnol Med

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The aim of this study was to develop and test a technique for scintigraphic examination of the thoracic aorta, which allows for visualizing foci of inflammation.Materials and Methods. The study included 15 patients (median age -61 [47; 73] years) with aortic dilatation more than 45 mm and thoracic aortic aneurysm who were candidates for surgical treatment. All patients underwent a chest scintigraphy with 99m Tc-pyrophosphate 48 h before surgery to identify foci of inflammation in the aortic wall. The new technique included intravenous administration of 370 MBq of a radiopharmaceutical (RP), registration of scintigrams at 3 and 6 h after injection of RP in a tomographic mode combined with X-ray computed tomography. After the image reconstruction, subtraction of the later scintigrams from the early ones was performed, followed by analysis of the final images. The results of scintigraphy were compared with the histological data obtained from intraoperative samples of resected aorta.Results. According to the results of this novel scintigraphic technique, artifacts from the radioactivity of the vascular blood pool were eliminated and pathological RP uptake was identified in 5 (33.3±1.5%) out of 15 examined patients. The "focus/vessel lumen" ratio averaged at 1. 47 [1.30; 1.48]. Histological examination of resected aorta samples confirmed the presence of chronic inflammation in 4 (26.7±1.3%) out of 15 patients. Parameters of diagnostic efficiency were: sensitivity -100%, specificity -91%, diagnostic accuracy -93%.Conclusion. The method of scintigraphic diagnostics of inflammatory processes in the aorta using 99m Tc-pyrophosphate, supplemented by subtraction of the late from the early images, makes it possible to eliminate artifacts from the radioactivity of the aortic blood pool and to reveal the pathological RP accumulation indicating the areas of inflammation in the aortic wall.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Ilyushenkova¹,

Панфилов²,

Саушкин³

et al. 2021

Sovrem Tehnol Med

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“…Although 99m Tc-PYP is inherently a marker of myocardial injury (myocardial infarction), its use is also reasonable for detection of myocarditis because inflammation is accompanied by the alternative processes. However, considering the recommendations for most radiopharmaceuticals used to diagnose inflammation, we increased the time interval between the 99m Tc-PYP injection and image acquisition recommended by protocols (1 to 3 h) to 24 hours (delayed image acquisition) [26]. It allowed getting rid of the intracardiac and intravascular pools and decreasing the number of false-positive results as much as possible.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

Ilyushenkova

Сазонова

Zavadovsky

et al. 2020

Cardiology Research and Practice

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Objectives. This work aimed to study the efficacy of hybrid 99mTc-Pyrophosphate SPECT/CT for diagnosis of latent inflammatory processes in the myocardium of patients with atrial fibrillation (AF). Methods. The study comprised 34 patients aged 44 ± 9 years with AF of unknown etiology referred for radiofrequency ablation. The data were acquired using hybrid 99mTc-Pyrophosphate SPECT/CT. To evaluate and interpret the results of hybrid study and to determine localization of radiopharmaceutical accumulation, scintigraphic and CT images were fused. SPECT/CT results were compared with data of endomyocardial biopsy. Results. Sensitivity, specificity, and accuracy of 99mTc-Pyrophosphate SPECT/CT in diagnosing myocarditis were 91%, 100%, and 94%, respectively. Proposed diagnostic criteria for myocarditis comprised intensity of the radiopharmaceutical accumulation in the myocardium and the ratios of focus/lung, focus/vertebral column, and focus/LV pool. Minimum cutoff values for the histologically verified myocarditis were >1.47 for focus/lung index, >0.11 for focus/vertebral column ratio, and >1.26 for focus/lung index. Conclusions. SPECT/CT-based quantitative assessment of 99mTc-Pyrophosphate accumulation in the myocardium is a highly informative noninvasive method for diagnosis of inflammatory process in the heart in patients with AF of undefined etiology.

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“…Moreover, there are data suggesting the presence of a positive correlation between the activity of the disease and the intensity of 99m Tclabelled leukocyte accumulation. According to the data of Sazonova (12), 99m Tc-HMPAO-labelled leukocyte scintigraphy used in diagnosing IE demonstrates a sensitivity rate of 75%, a specificity rate of 90%, a diagnostic accuracy rate of 79%, a positive predictive value of 94%, and a negative predictive value of 60%. Due to the rapid development of radiological equipment, hybrid devices with the ability to overlay images of different modalities (PET-CT, SPECT-CT, etc.)…”

Section: Discussionmentioning

confidence: 99%

99mTc-HMPAO-Labeled Autologous Leukocyte SPECT/CT for Diagnosis of Bacterial Endocarditis of the Prosthetic Pulmonary Conduit: A Clinical Case

et al. 2016

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In this paper, we present a case of bacterial endocarditis of the prosthetic pulmonary conduit found in a 26-year-old man. An echocardiography study around the pulmonary valve showed the presence of a floating mass attached to the wall of the conduit. This formation was thought to be a floating calcific leaflet of the conduit or a developed vegetation of the conduit. Due to the uncertainty of the results, pulmonary multidetector row computed tomography (MDCT) angiography was performed. The MDCT examination showed the presence of a floating 4 × 8-mm sized mass in the pulmonary conduit. Taking into account the patient's complaints, medical history data, and clinical-instrumental examination, myocardial scintigraphy with 99m Tc-HMPAO-labelled autologous leukocytes combined with CT ( 99m Tc-HMPAO-SPECT/CT) was performed. Based on overlaying of the scintigraphic images and the MDCT aortography scans, anatomic localization of the pathologic accumulation was found in a projection of the pulmonary valve prosthesis. Surgical intervention, with cardiopulmonary bypass, was performed for replacement of the valve-containing conduit. Pathomorphologic study of the surgical material confirmed the hypothesis of bacterial endocarditis. Therefore, hybrid technologies such as 99m Tc-HMPAO-SPECT/CT contribute to the earlier and more precise diagnosis of infectious endocarditis, avoiding many errors associated with patient treatment and the development of complications.

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Modern Opportunities of Radionuclide Methods for Diagnosis of Inflammatory Processes in the Myocardium

Cited by 3 publications

References 23 publications

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

99mTc-HMPAO-Labeled Autologous Leukocyte SPECT/CT for Diagnosis of Bacterial Endocarditis of the Prosthetic Pulmonary Conduit: A Clinical Case

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Modern Opportunities of Radionuclide Methods for Diagnosis of Inflammatory Processes in the Myocardium

Cited by 3 publications

References 23 publications

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Scintigraphic Imaging of Inflammation in the Aortic Wall Using 99mTc-Pyrophosphate

Diagnostic Efficacy of Cardiac Scintigraphy with 99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation

99mTc-HMPAO-Labeled Autologous Leukocyte SPECT/CT for Diagnosis of Bacterial Endocarditis of the Prosthetic Pulmonary Conduit: A Clinical Case

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Diagnostic Efficacy of Cardiac Scintigraphy with ^99mTc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation