Modern Methods of Treatment of Recurrent Unresectable Squamous Cell Carcinoma of Larynx (Literature Review)

Анатольевич, Рожнов Виталий; Георгиевич, Андреев Вячеслав; Борисович, Гордон Константин; Александрович, Гулидов Игорь; Диляверович, Акки Эрнест

doi:10.21294/1814-4861-2016-15-2-90-100

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The original 3D conformal option has not been properly tested for reRT, which is a rather new clinical paradigm [50,51]. As the intensity-modulated modifications afford better distribution of the dose within irradiated volume, the original version is preserved mostly for comparative purposes.…”

Section: D Conformal Radiotherapy and Its Modificationsmentioning

confidence: 99%

An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?

Gordon,

Smyk,

Gulidov

et al. 2023

Cancers

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The recurrence rate of head and neck cancers (HNCs) after initial treatment may reach 70%, and poor prognosis is reported in most cases. Curative options for recurrent HNCs mainly depend on the treatment history and the recurrent tumor localization. Reirradiation for HNCs is effective and has been included in most guidelines. However, the option remains clinically challenging due to high incidence of severe toxicity, especially in cases of quick infield recurrence. Recent technical advances in radiation therapy (RT) provide the means for upgrade in reirradiation protocols. While the majority of hospitals stay focused on conventional and widely accessible modulated RTs, the particle therapy options emerge as tolerable and providing further treatment opportunities for recurrent HNCs. Still, the progress is impeded by high heterogeneity of the data and the lack of large-scale prospective studies. This review aimed to summarize the outcomes of reirradiation for HNCs in the clinical perspective.

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Section: D Conformal Radiotherapy and Its Modificationsmentioning

confidence: 99%

An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?

Gordon,

Smyk,

Gulidov

et al. 2023

Cancers

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Proton beam therapy in repeat irradiation of recurrent head and neck tumors: analysis of short-term results

Смык

Гулидов

Гордон

et al. 2023

Opuholi golovy i šei

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Introduction. Recurrence of head and neck tumors occurs in 50 % of cases and usually has locoregional character. Due to the characteristics of dose distribution, proton beam therapy is a promising treatment option for patients with recurrences of tumors in this location who previously underwent radiation therapy.Aim. To evaluate the effectiveness and tolerability of repeat irradiation using active scanning proton beam therapy in patients with recurrent head and neck tumors who previously underwent radiation therapy.Materials and methods. Between November of 2015 and December of 2020, 40 patients with locoregional recurrence of head and neck tumors underwent treatment using active scanning proton beam therapy at the A. F . Tsyb Medical Radiological Research Center – branch of the National Medical Research Radiological Center. Median cumulative dose of primary irradiation was 64.5 Gy. Median time between primary and repeat irradiation was 35.7 months, mean irradiated volume of the repeat course was 94.5 cm3. Proton beam therapy was performed using standard mode (2 isoGy) and accelerated hypofractionation (2.4 isoGy / 3 isoGy) with mean equivalent cumulative dose of 56.4 Gy (α / β = 10). Radiation toxicity was evaluated using the Radiation Therapy Oncology Group European (RTOG) / Organization for Research and Treatment of Cancer (EORTC) scale.Results. Treatment response was achieved in 34 (85 %) patients: in 17 (42.5 %) patients, stable disease was observed; in 10 (25 %) patients, partial response was observed; and in 7 (17.5 %) patients, complete response was observed. In 6 (15 %) cases, disease progression was diagnosed at first follow-up examination. One- and two-year locoregional control, progression-free survival and overall survival were 58.4 / 19.8; 44.5 / 19.8 and 82.3 / 38.8 % respectively with median follow-up duration of 14.2 months. Median survival was 19.5 months. Grade III and above early radiation toxicity was observed in 3 (7.5 %) patients. In total, 6 (15 %) cases of grade III complications and 2 (5 %) episodes of carotid artery rupture leading to death were observed. Overall frequency of complications of grade III and higher was 20 %.Conclusion. Repeat irradiation using proton beam therapy can be considered an effective and safe treatment method for patients with recurrent head and neck tumors. Dosimetric and radiobiological benefits of proton beams allow to achieve balance between high doses and radiation exposure in previously irradiated tissues.

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Modern Methods of Treatment of Recurrent Unresectable Squamous Cell Carcinoma of Larynx (Literature Review)

Cited by 2 publications

References 11 publications

An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?

An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?

Proton beam therapy in repeat irradiation of recurrent head and neck tumors: analysis of short-term results

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