Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review

Abstract

Coumarin is an important pharmaceutical structural motif, abundantly found in numerous commonly used drugs. Compounds containing this core show a broad spectrum of medicinal properties and biological activities. The increasing...

New Coumarin Derivatives Accessible in Short and Eco-Friendly Conditions with Antifungal Activity

“…The purity of compounds (5a-g) was assessed by NMR and LCMS. 6 Hz, J=3.0 Hz, 1H), 6.16 (s, 1H), 3.17 (q, J=6.1 Hz, 2H), 1.59 (q, J=6.0 Hz, 2H), 1.35 (q, J=5.9 Hz, 2H), 1.69 (t, J=7.2 Hz, 3H), 0.98 (q, J=6. 3 General procedure for the preparation coumarinopyridones (9).…”

“…The chemical modifications performed on naturally occurring coumarins have mostly dealt with the modification of existing substituents and functions or the introduction of new substituents on the carbon skeleton [4,5]. The availability of modern and recent synthetic methods have boosted the interest toward coumarin-derived bioactive molecules [6]. In this regard, coumarins bearing pyridine rings have attracted the interest of medicinal chemists [7].…”

One‐pot green synthesis, study of fluorescence properties, and biological activity of pyrano[3,2‐c]chromenes derivatives via mesoporous materials MgO/SBA‐15

“…Over the past two decades, the development of mesoporous materials has been a popular area of research due to their large surface area, high pore volume, and well‐defined pore sizes [3, 4] and ease of chemical modification [5, 6]. The catalytic properties have been explored after doping transition metals [7–13] in silica frameworks to obtain metal silicates. The insertion of alkaline earth metals, including magnesium, into a silica framework can increase the surface basicity of the framework, opening up many applications for the material.…”

In Silico and In Vitro Studies of 4-Hydroxycoumarin-Based Heterocyclic Enamines as Potential Anti-Tumor Agents

“…Different strategies can be used to derivatize these heterocyclic compounds, but multistep synthesis routes often affect the yields of the final products. Therefore, one-step optimized reactions are always preferred to obtain good yields in shorter times [23].…”

“…Different strategies can be used to derivatize these heterocyclic compounds, but multistep synthesis routes often affect the yields of the final products. Therefore, one-step optimized reactions are always preferred to obtain good yields in shorter times [23]. Although many derivatives of coumarins have been tested recently, the target selection and proper delivery of anti-tumor agents to the target area still require the development of new derivatives.…”