Modern management of thin lining

Mouhayar, Youssef; Sharara, Fady I.

doi:10.1016/j.mefs.2016.09.001

Cited by 14 publications

(11 citation statements)

References 124 publications

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“…This finding did not indicate the ability of green tea extract in improving DMPA-induced endometrial atrophy. It is known that endometrial proliferation depends on oestrogen level, which causes the progressive growth of functional endometrium in the proliferative phase 29 . Flavonoids and triterpenes are components of green tea that move like oestrogen,30, 31, 32, 33 but this study showed no significant result.…”

Section: Discussionmentioning

confidence: 57%

Protective effect of green tea on tunica adventitia and endothelial changes resulting from depot medroxy progesterone acetate

Veri

Mutiah

et al. 2019

Journal of Taibah University Medical Sciences

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Objective This study aimed to analyse the effects of green tea in inhibiting uterine atrophy and vascular changes due to the use of depot medroxy progesterone acetate (DMPA). Methods Twenty-five female Wistar rats aged one to two months were randomly assigned to five treatment groups: control group, DMPA-induced group, and DMPA-induced group orally treated with green tea extract (at 10.8 mg/day, 21.6 mg/day, or 43.2 mg/day). Histologic analysis of uterine and vascular tissues was performed with haematoxylin-eosin staining. Results DMPA decreased the thickness of endometrium and tunica adventitia, as well as significantly decreased endothelial cell count ( p < 0.05). DMPA-induced decreases in the thickness of tunica adventitia and endothelial cell count could be significantly inhibited by green tea extract ( p < 0.05). Conclusion This study concluded that DMPA triggered the depletion of uterine endometrium and vascular tunica adventitia and decreased endothelial cell count. Green tea extract at the highest dose normalized tunica adventitia and endothelial changes to the basal value.

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Section: Discussionmentioning

confidence: 57%

Protective effect of green tea on tunica adventitia and endothelial changes resulting from depot medroxy progesterone acetate

Veri

Mutiah

et al. 2019

Journal of Taibah University Medical Sciences

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“…Over the years, several treatment options have been suggested and assessed as a treatment for refractory thin endometrium with or without Asherman's syndrome [19]. Extended estrogen therapy, luteal GnRH-a supplementation, low-dose HCG during endometrial preparation, tamoxifen citrate as an ovulation induction agent, long courses of pentoxiphylline and tocopherol or tocopherol only, aspirin, acupuncture, and neuromuscular electric stimulation with biofeedback were all inconsistent in improving endometrial thickness [19]. Vaginal sildenafil improved the endometrial thickness in a significant percentage of patients with thin lining due to various diagnoses that had prior IVF and ICSI cycles, indicating that it could be a reasonable first-line treatment option [19].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, Lebovitz et al concluded that the treatment of Bthinê ndometrium remains a challenge, with only minor improvements achieved with the currently available treatment modalities [18]. We have recently published a detailed review that aimed at defining thin endometrium in infertility patients and concluded that of the available treatment modalities, only vaginal sildenafil and intrauterine granulocyte colonystimulating factor (G-CSF) were consistent in showing improvement in endometrial thickness and pregnancy rates of patients with thin endometrium, and that early stem cell results are promising [19]. Here, we provide a focused review on emerging and promising treatment options for refractory thin endometrium, namely, intrauterine G-CSF and stem cell therapy.…”

Section: Introductionmentioning

confidence: 99%

G-CSF and stem cell therapy for the treatment of refractory thin lining in assisted reproductive technology

Mouhayar

Sharara

2017

J Assist Reprod Genet

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“…A meta-analysis demonstrated that reduced EMT leads to low pregnancy rates [5]. Mouhayar and Sharara reported that among the various available modalities, only G-CSF and vaginal sildenafil had a demonstrable impact on the endometrium [6]. G-CSF has gained considerable importance in recent years after an initial study by Gleicher et al demonstrated successful treatment of thin endometrium, followed by several other researchers [7-8].…”

Section: Introductionmentioning

confidence: 99%

Mediator in the Embryo-endometrium Cross-talk: Granulocyte Colony-stimulating Factor in Infertility

Robert

Abbas

Zaidi

et al. 2019

Cureus

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Successful implantation requires a receptive endometrium and a good quality egg. The challenges a physician encounters with regard to this in assisted reproductive technology are obtaining good quality embryo, achieving optimal endometrial thickness (EMT), and subsequently implantation, which is denotive of a receptive endometrium. Granulocyte colony-stimulating factor (G-CSF) has been observed to be a biomarker of oocyte quality and has been shown to enhance EMT and implantation because of its immunological effects. A systematic search for all relevant articles on G-CSF in follicular fluid and its therapeutic benefit in thin endometrium and recurrent implantation failure was performed, and peer-reviewed, full-text articles related to humans were included in the study. As a tool to determine the potentiality of oocyte, G-CSF shows promise with its predictability increasing in combination with morphological embryo scoring or interleukin 15. For the thin endometrium, G-CSF is especially useful in patients who are refractory to other treatment modalities. In recurrent implantation failure (RIF), G-CSF showed potential in a subset of patients with immunological deficiency lacking killer cell immunoglobulin-like receptor genes. This review highlights the various forms of usage of G-CSF and the effectiveness of G-CSF in infertility. G-CSF equips embryologists with a tool to determine the potentiality of oocyte and physicians with therapy for thin endometrium and RIF, especially since the available treatment options are ineffective.

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Modern management of thin lining

Cited by 14 publications

References 124 publications

Protective effect of green tea on tunica adventitia and endothelial changes resulting from depot medroxy progesterone acetate

Protective effect of green tea on tunica adventitia and endothelial changes resulting from depot medroxy progesterone acetate

G-CSF and stem cell therapy for the treatment of refractory thin lining in assisted reproductive technology

Mediator in the Embryo-endometrium Cross-talk: Granulocyte Colony-stimulating Factor in Infertility

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