Modern management of genitourinary syndrome of menopause

Silva, Ana Sofia Da; Baines, Georgina; Araklitis, George; Robinson, Dudley; Cardozo, Linda

doi:10.12703/r/10-25

Cited by 15 publications

(11 citation statements)

References 58 publications

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“…Selective oestrogen receptor modulators are a synthetic nonsteroidal class of drugs, which act on the oestrogen receptor 1 . is taken orally and is the only agent that has been approved for the treatment of GSM and been shown to be effective compared with placebo 11 . Further studies are needed to assess safety in patients with breast cancer.…”

Section: Hormonal Therapymentioning

confidence: 99%

Menopause, skin and common dermatosis. Part 3: genital disorders

Musbahi

Kamp

Ashraf

et al. 2022

Clinical and Experimental Dermatology

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Oestrogen plays a vital role in maintaining a normal vulvovaginal epithelium, vaginal lubrication, as well as a healthy microbiome to ensure an acidic pH. The decrease in oestrogen levels in women going through menopause results in both physiological and physical changes of the genitourinary system, and more specifically the vulva. We conducted a literature review on the effects of low oestrogen levels on the physiology and function of the vulva and the vulvovaginal epithelium. 'Genitourinary syndrome of menopause' (GSM) is the term used to describe the signs and symptoms of a low oestrogen state. The symptoms and signs of GSM can overlap or coexist with other vulval dermatoses. Expert opinion is needed to diagnose and manage vulval dermatoses in menopause. This article will discuss the signs and symptoms of GSM, as well as the different management options available. Other vulval dermatoses that can be affected by hypo-oestrogenism are also reviewed.

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Section: Hormonal Therapymentioning

confidence: 99%

Menopause, skin and common dermatosis. Part 3: genital disorders

Musbahi

Kamp

Ashraf

et al. 2022

Clinical and Experimental Dermatology

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“…Слід зазначити, що наслідки ССМ здатні погіршувати якість життя жінки. На відміну від вазомоторних симптомів, які з часом можуть стати менш вираженими, симптоми ССМ прогресують і мають тенденцію до посилення, якщо не проводити лікування, крім того, таки симптоми майже ніколи не зникають спонтанно [1,2,5].…”

Section: роль негормональных методов лечения мочеполового синдрома ме...unclassified

“…За результатами багатьох проспективних обсерваційних досліджень щодо лікування відповідних захворювань, доведено добру переносимість препаратів, що містять ГК, завдяки збереженню консистенції тканин, полегшенню клітинної міграції при запаленні, покращанню стану тканин і процесів регенерації, а також відсутності побічних ефектів [2,10,15].…”

Section: роль негормональных методов лечения мочеполового синдрома ме...unclassified

“…За останні роки отримано нові дані щодо ефективності продуктів, що вводять вагінально, разом з періодичним оцінюванням їхніх переваг, яке проводять лікарі та користувачі. Це дало можливість покращити якість життя жінкам з ССМ, а також надати рекомендації щодо особливостей їхнього призначення та використання [2,6,12,14].…”

Section: роль негормональных методов лечения мочеполового синдрома ме...unclassified

“…Ефективним є вагінальне застосування саме високих доз вітаміну Е -щонайменше 100 мг. У цьому випадку вітамін Е зумовлює поліпшення відновлення клітин та зменшення симптомів диспареунії і може бути рекомендований як альтернатива місцевому естрогену при протипоказаннях або відмові пацієнтки від вживання гормональних препаратів [1,2,3,15].…”

Section: роль негормональных методов лечения мочеполового синдрома ме...unclassified

See 2 more Smart Citations

The role of non-hormonal methods in treatment of urogenital menopausal syndrome: modern views

Davydova

Lymanska

Dvulit³

et al. 2021

RHW

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The article is devoted to a review of the literature on the problem of overcoming the negative outcomes of the genitourinary syndrome of menopause (GSM). It is known that a woman is in menopause almost 30–40% of her life, and according to WHO, by 2030, 1.2 billion women will be in postmenopause. At the same time, there is an increase in life expectancy in developed countries, which also leads to an increase in the number of women with GSM. The article presents the pathogenetic mechanisms of the development of GSM, in particular, it is indicated that the occurrence and degree of manifestations of this pathology are proportional to the decrease in estrogens level and their metabolism in the organism. The prevalence of GSM symptoms among menopausal women has been shown in the article. The negative impact of the GSM outcomes on the quality of life of patients is described. Women who are sexually active during menopause are more likely to have the manifestations of this pathology and consult with the doctor, but sexually inactive women can also benefit from awareness of the manifestations and the treatment of GSM. Unlike vasomotor symptoms, which may become less pronounced over time, the manifestations of GSM progress if not to treat them, tend to more severe course, and almost never disappear spontaneously.Modern approaches to the treatment of this pathology are also given. In particular, the possibility of prescribing plant therapy as an alternative to menopausal hormone therapy is considered. Herbal medicines can be used for a long time and without health risks. A range of vaginal oils, vaginal moisturizers with hyaluronic acid, isoflavones (a medicine with fennel, chamomile and saffron) are commonly used to treat women with GSM.The article discusses the issues of recommendations for the prescription of herbal therapy, its advantages and features of use. The possibility of treating the symptoms of GSM for sexually active and inactive women with vaginal suppositories, which include hyaluronic acid (in the form of sodium salt), tocopherol acetate, Asian centella extract, chamomile flower extract, calendula officinalis flower extract, which have a moisturizing, regenerative effect, antiseptic, anti-inflammatory action for the rapid restoration of the vaginal mucosa. The effectiveness and safety of such therapy was established.

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A study of the objective benefits and safety of Er-YAG laser in the treatment of genitourinary syndrome of menopause

Avul¹,

Guven²

2023

Lasers Med Sci

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Modern management of genitourinary syndrome of menopause

Cited by 15 publications

References 58 publications

Menopause, skin and common dermatosis. Part 3: genital disorders

Menopause, skin and common dermatosis. Part 3: genital disorders

The role of non-hormonal methods in treatment of urogenital menopausal syndrome: modern views

A study of the objective benefits and safety of Er-YAG laser in the treatment of genitourinary syndrome of menopause

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