Modern Management of Acute Liver Failure

O’Grady, John

doi:10.1016/j.cld.2007.04.011

Cited by 53 publications

(32 citation statements)

References 48 publications

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“…The success of auxiliary transplantation depends on the ability of the native liver to regenerate. This procedure is best suited for patients with hyperacute liver failure due to acetaminophen toxicity without any prior liver disease (O'Grady 2007(O'Grady , 2012. Additional criteria used in a 2014 study evaluating outcomes of 24 patients with whole graft auxiliary transplant for acetaminophen overdose included meeting the King's College Criteria, age <50 years, no prolonged circulatory arrest, and a cerebral perfusion pressure >40 mmHg (Lodge et al 2008).…”

Section: Liver Transplantationmentioning

confidence: 99%

Acetaminophen hepatotoxicity: an updated review

2014

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Section: Liver Transplantationmentioning

confidence: 99%

Acetaminophen hepatotoxicity: an updated review

2014

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“…The current medical treatment is limited to patient support until the liver recovers spontaneously or a replacement liver becomes available (1). Although liver transplantation has become a somewhat standard treatment in these patients, a number of disadvantages of this option remain in such cases, such as organ shortage, long-term administration of immunosuppressant, acute or late complications after liver transplantation, and poor outcomes in patients not eligible for liver transplant.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow mononuclear cell transplant therapy in mice with CCl4-induced acute liver failure

Jin

Sun²,

Han³

et al. 2012

Turk J Gastroenterol

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“…Fulminant hepatic failure (FHF) is a complex clinical condition that is only partially understood and remains a major clinical challenge [1,2] . Hepatic encephalopathy (HE) associated with intracranial hypertension is a severe neurologic complication and the leading cause of death among patients with FHF [3] .…”

Section: Introductionmentioning

confidence: 99%

Multimodal brain monitoring in fulminant hepatic failure

Paschoal¹,

Nogueira²,

Ronconi³

et al. 2016

WJH

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Acute liver failure, also known as fulminant hepatic failure (FHF), embraces a spectrum of clinical entities characterized by acute liver injury, severe hepatocellular dysfunction, and hepatic encephalopathy. Cerebral edema and intracranial hypertension are common causes of mortality in patients with FHF. The management of patients who present acute liver failure starts with determining the cause and an initial evaluation of prognosis. Regardless of whether or not patients are listed for liver transplantation, they should still be monitored for recovery, death, or transplantation. In the past, neuromonitoring was restricted to serial clinical neurologic examination and, in some cases, intracranial pressure monitoring. Over the years, this monitoring has proven insufficient, as brain abnormalities were detected at late and irreversible stages. The need for real-time monitoring of brain functions to favor prompt treatment and avert irreversible brain injuries led to the concepts of multimodal monitoring and neurophysiological decision support. New monitoring techniques, such as brain tissue oxygen tension, continuous electroencephalogram, transcranial Doppler, and cerebral microdialysis, have been developed. These techniques enable early diagnosis of brain hemodynamic, electrical, and biochemical changes, allow brain anatomical and physiological monitoring-guided therapy, and have improved patient survival rates. The purpose of this review is to discuss the multimodality methods available for monitoring patients with FHF in the neurocritical care setting.

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Modern Management of Acute Liver Failure

Cited by 53 publications

References 48 publications

Acetaminophen hepatotoxicity: an updated review

Acetaminophen hepatotoxicity: an updated review

Bone marrow mononuclear cell transplant therapy in mice with CCl4-induced acute liver failure

Multimodal brain monitoring in fulminant hepatic failure

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