The article delves into an important problem known as clustering in the tourism hotel business. The authors attempted to examine the different aspects of the formation of the tourist hotel cluster which allow to increase the economic efficiency of the network structure. The researchers concentrated on the system of formation of tourist hotel cluster for increasing the economic efficiency of the network structure. The network structure of tourist hotels has a number of advantages, which is examined in this article. The key aspect of the system of formation of tourist hotel cluster is creating a structural basis, marketing activities, formation of internal standards. The formation of tourist hotel cluster includes the following elements: inventory of fixed assets of participants, SWOT-analysis, assessment of the potential of all participants of the tourist hotel cluster, analysis of marketing internal and external environment in hotel services, identification of all possible risks and benefits of the cluster, implementation of organizational, legal, social, psychological adaptation of participants to integration in the cluster, the formation of strategies for the development of the tourist hotel cluster, coordination the conditions for participants to join the cluster and further activities in the cluster, preparation for the concluding and signing of contracts. In the study motivational factors and benefits of merging enterprises into tourist hotel clusters were identified by the authors. These motivating factors allow to increase the economic efficiency of the network structure.